Abstract:
:Recently, it has been hypothesized that the N-terminal portion of substance P (SP), SP(1-7), which results from the action of endopeptidase 24.11 (EC3.4.24.11), could be involved in mediating the depressor effects of baroreceptor afferent activation via its action on cells in the nucleus tractus solitarius (NTS). In this study, the binding of a monoclonal antibody to endopeptidase 24.11 was examined immunohistochemically at the level of the caudal medulla of the rat brain. By light microscopy, intense immunoreactivity was seen in the NTS, in fibers bordering the area postrema, and in the area postrema itself. After electron microscopy, endopeptidase 24.11-like immunoreactivity was seen to be associated with the cytoskeleton and plasma membrane in axons, dendrites and glial processes. Antigen was also associated with synaptic vesicles and plasma membranes in presynaptic terminals forming mainly axo-dendritic synapses typical of vagal afferent terminals involved in the baroreceptor reflex. Thus, endopeptidase 24.11 appears to be localized at sites where it could effectively process SP prior to its binding to postsynaptic receptors.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Lasher RS,Lutz EM,Mulholland F,Sanderson R,Stewart JM,Bublitz Cdoi
10.1016/0304-3940(90)90117-rsubject
Has Abstractpub_date
1990-09-04 00:00:00pages
43-9issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(90)90117-Rjournal_volume
117pub_type
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