Abstract:
:The neurotoxicity of the glutamate receptor agonists N-methyl-D-aspartate (NMDA), (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), and kainate was quantitatively assessed in murine spinal cord and cortical cultures prepared under identical conditions. Compared with cortical neurons, spinal neurons were less vulnerable to NMDA (EC50 for 24 h exposure about 30 microM versus 10 microM in cortical cultures) and more vulnerable to AMPA (EC50 5 microM versus 12 microM) and kainate (EC50 20 microM versus 50 microM). Neurons subject to kainate-activated cobalt uptake, a marker of calcium-permeable AMPA/kainate channels, were resistant to NMDA in both systems; these cells were significantly more prevalent in spinal cord cultures. Both the AMPA/kainate antagonist GYKI-52466 and the NMDA antagonist MK-801 attenuated spinal cord neuronal loss due to glucose deprivation; however, GYKI-52466 was more effective. These results support the hypothesis that AMPA/kainate receptor activation may play a significant role in excitotoxic injury to spinal cord neurons.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Regan RFdoi
10.1016/0304-3940(96)12823-8subject
Has Abstractpub_date
1996-07-26 00:00:00pages
9-12issue
1eissn
0304-3940issn
1872-7972pii
0304394096128238journal_volume
213pub_type
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90216-x
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2004-11-11 00:00:00
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2016-05-27 00:00:00
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journal_title:Neuroscience letters
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更新日期:2015-01-12 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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