Involvement of insulin-like growth factor binding protein-2 in activated microglia as assessed in post mortem human brain.

abstract：:Hippocampal volumetry has been proposed to aid in the early diagnosis of Alzheimer's disease (AD) and to monitor progression of the disease. While this is believed to be as a result of hippocampal neuron loss, this association has not been firmly established and loss of other tissue elements may be responsible for the...

journal_title：Neuroscience letters

authors： Kril JJ,Hodges J,Halliday G

更新日期：2004-05-06 00:00:00

abstract：:It is known that the number of newly generated neurons is increased in the young and adult rodent subventricular zone (SVZ) and dentate gyrus (DG) after transient brain ischemia. However, it remains unclear whether increase in neurogenesis in the adult DG induced by ischemic stroke is transient or sustained. We here r...

journal_title：Neuroscience letters

authors： Wang C,Zhang M,Sun C,Cai Y,You Y,Huang L,Liu F

更新日期：2011-01-13 00:00:00

abstract：:The reversible specific binding of [3H]diazepam was observed by a radioligand method in homogenates of cultured cells of mouse glioblastoma. It was characterized by an equilibrium dissociation constant Kd = 91 +/- 5 nM and the number of maximal binding sites (Bmax) of 1006 +/- 100 fmol/mg protein. The half-saturation ...

journal_title：Neuroscience letters

authors： Zlobina GP,Kondakova LI,Khalansky AS

更新日期：1984-12-21 00:00:00

abstract：:The cyclic AMP/protein kinase A signaling pathway is thought to be involved in neural differentiation of mesenchymal stem cells. In the present study, we examined the involvement of β-adrenoceptor signaling on the differentiation of mouse induced pluripotent stem (iPS) cells into neural progenitor cells. Mouse iPS cel...

journal_title：Neuroscience letters

authors： Ishizuka T,Goshima H,Ozawa A,Watanabe Y

更新日期：2012-09-06 00:00:00

abstract：:The role of 5-HTTLPR and 5-HT2C Cys23Ser polymorphisms in the psychopathology of mood disorders and suicide behavior is controversial. The aim of present study was to investigate the association between 5-HTTLPR and 5-HT2C Cys23Ser variants and susceptibility to bipolar I disorder (BID). The 5-HT2C genotypes were stud...

journal_title：Neuroscience letters

authors： Mohammadi S,Khazaie H,Rahimi Z,Vaisi-Raygani A,Zargooshi N,Rahimi Z

更新日期：2015-03-17 00:00:00

abstract：:In chick brain microvessels, monoamine oxidase activity using catecholamines (dopamine and noradrenaline) and indoleamines (serotonin and tryptamine) as substrates was higher than that measured in synaptosomes and free mitochondria. In contrast, phenylalkyamines such as tyramine and 2-phenylethylamine were more deamin...

journal_title：Neuroscience letters

authors： Durand M

更新日期：1986-12-12 00:00:00

abstract：:We are attempting to determine the neuronal factors that influence upper airway patency during sleep in the elderly. Serotonin has a facilitatory effect on hypoglossal motoneurons that innervate the tongue, and manipulations of the serotonergic system alter airway patency. We hypothesized that age-associated changes i...

journal_title：Neuroscience letters

authors： Behan M,Brownfield MS

更新日期：1999-05-28 00:00:00

abstract：:Stroke in rodents is associated with increased neurogenesis and the migration of newborn neurons to sites of brain ischemia, where they may participate in repair and recovery. To determine if neurogenesis following stroke yields functional new neurons, we labeled neuronal precursors in the mouse subventricular zone (S...

journal_title：Neuroscience letters

authors： Lai B,Mao XO,Xie L,Jin K,Greenberg DA

更新日期：2008-09-19 00:00:00

abstract：:Tobacco smoke inhibits monoamine oxidase-B (MAO-B) activity in vitro and in vivo, suggesting that MAO-B inhibition is a possible contributing factor to tobacco smoke addiction. Thus, MAO-B is a possible candidate gene for predisposition to smoking. The TaqIB polymorphism for the Dopamine D2 Receptor gene (DRD2) has be...

journal_title：Neuroscience letters

authors： Costa-Mallen P,Costa LG,Checkoway H

更新日期：2005-09-09 00:00:00

abstract：:The nitric oxide (NO)-cGMP signaling system and cAMP system play critical roles in the formation of multiple-trial induced, protein synthesis-dependent long-term memory (LTM) in many vertebrates and invertebrates. The relationship between the NO-cGMP system and cAMP system, however, remains controversial. In honey bee...

journal_title：Neuroscience letters

authors： Matsumoto Y,Hatano A,Unoki S,Mizunami M

更新日期：2009-12-25 00:00:00

abstract：:The effect of a chronic 17 beta-estradiol (10 micrograms, b.i.d.) treatment of 2 weeks to ovariectomized rats was investigated on lateral and medial caudate-putamen dopamine receptors. Dopamine D2 receptors were assayed with [3H]spiperone binding to caudate-putamen homogenates or by autoradiography of forebrain sectio...

journal_title：Neuroscience letters

authors： Falardeau P,Di Paolo T

更新日期：1987-02-10 00:00:00

abstract：:Vesicular monoamine transporter 2 (VMAT2) is responsible for packing dopamine into vesicles, and reduces the effects of neurotoxins by sequestering them into vesicles. In this report, we tested the hypothesis that VMAT2 is associated with Lewy body (LB) formation by immunohistochemical staining of midbrain and cortica...

journal_title：Neuroscience letters

authors： Yamamoto S,Fukae J,Mori H,Mizuno Y,Hattori N

更新日期：2006-04-03 00:00:00

abstract：:L1 is a highly conserved cell adhesion molecule with complete homology of the cytoplasmic domain between the known mammalian protein sequences. Since the cytoplasmic domains of other adhesion molecules have been shown to influence adhesion, we have investigated the effects of deletion of the cytoplasmic domain on the ...

journal_title：Neuroscience letters

authors： Wong EV,Cheng G,Payne HR,Lemmon V

更新日期：1995-11-24 00:00:00

abstract：:Previous studies suggest that neuropeptide FF (NPFF) plays a role in opiate dependence and subsequent abstinence syndrome. Endogenous NPFF also appears to play a role in opiate tolerance since third ventricle injection of IgG from NPFF antiserum selectively restores morphine sensitivity in morphine-tolerant rats. The ...

journal_title：Neuroscience letters

authors： Lake JR,Hebert KM,Payza K,Deshotel KD,Hausam DD,Witherspoon WE,Arcangeli KA,Malin DH

更新日期：1992-11-09 00:00:00

abstract：:Pharmacologic blockade of excitatory amino acid receptors, especially the N-methyl-D-aspartate-preferring subclass of glutamate receptors, has been shown to reduce neuronal damage in models of global cerebral ischemia followed by reperfusion. The pharmacologic blockade at the NMDA receptor attenuates infarct size foll...

journal_title：Neuroscience letters

authors： Roman R,Bartkowski H,Simon R

更新日期：1989-09-25 00:00:00

abstract：:Protein profiling of cerebrospinal fluid in Guillain-Barrè syndrome (GBS), an acute and immune-mediated disease affecting the peripheral nervous system, was performed by two-dimensional electrophoresis. Significant modulated spots in GBS patients vs. control groups (a group of multiple sclerosis patients and one of he...

journal_title：Neuroscience letters

authors： D'Aguanno S,Franciotta D,Lupisella S,Barassi A,Pieragostino D,Lugaresi A,Centonze D,D'Eril GM,Bernardini S,Federici G,Urbani A

更新日期：2010-11-12 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) is the major inhibitory transmitter in the mammalian central nervous system (CNS) and an understanding of the development of receptors for this compound is of considerable interest. In this study, 3 monoclonal antibodies directed against the GABAA/benzodiazepine (GABA/BDZ) receptor were ...

journal_title：Neuroscience letters

authors： Ventimiglia R,Grierson JP,Gallombardo P,Sweetnam PM,Tallman JF,Geller HM

更新日期：1990-07-31 00:00:00

abstract：:Superoxide dismutase 1 (SOD1) aggregates are a histological and biochemical correlate of disease progression in neural tissues from mutant SOD1-linked forms of familial amyotrophic lateral sclerosis (FALS). In the present study, we assayed the monomeric and high molecular weight mutant SOD1 content of nervous, muscle ...

journal_title：Neuroscience letters

authors： Turner BJ,Lopes EC,Cheema SS

更新日期：2003-10-23 00:00:00

abstract：:Almost all of the important pathophysiological targets for ethanol in the nervous system appear to be specific membrane proteins involved in signal transduction. In this paper we have examined levels and functionality of the alpha subunit of the Go protein (Goalpha) in cerebral cortex and cerebellum from rats that hav...

journal_title：Neuroscience letters

authors： Guillén A,García-Villafranca J,Mata F,Homburger V,Castro J

更新日期：2003-12-26 00:00:00

abstract：:In CA3 pyramidal neurons of guinea pig hippocampal slices an outward current activated by the GABAB agonist, baclofen (0.3 microM, Ibac) was reduced by low concentrations of carbachol (Cch, 0.1-0.3 microM). The effect of Cch desensitized suggesting that the receptor subtype involved in this muscarinic effect of Cch wa...

journal_title：Neuroscience letters

authors： Müller W,Brunner H,Misgeld U

更新日期：1989-05-22 00:00:00

abstract：:To investigate the contribution of nigral degeneration to the development of parkinsonism in the early stages of corticobasal degeneration (CBD), we measured the cerebrospinal fluid (CSF) levels of homovanillic acid (HVA) in patients with early CBD (n = 5), and compared the levels with those in patients with early Par...

journal_title：Neuroscience letters

authors： Kanemaru K,Mitani K,Yamanouchi H

更新日期：1998-04-03 00:00:00

abstract：:Diabetic polyneuropathy is a common and disturbing complication of diabetes mellitus, presenting patients and caregivers with a substantial disease burden. Emerging mechanisms which are underlying diabetes may provide novel pathways to understand diabetic polyneuropathy (DPN). Specifically, non-coding RNA molecules co...

journal_title：Neuroscience letters

authors： Meydan C,Üçeyler N,Soreq H

更新日期：2020-07-13 00:00:00

abstract：:Electrical stimulation of the primary auditory cortex (AI) of the cat was found to evoke EPSPs, IPSPs or EPSP-IPSP sequences in colliculogeniculate (CG) neurons in the inferior colliculus (IC) which responded antidromically to stimulation of the medial geniculate nucleus. The CG neurons responding to the AI stimulatio...

journal_title：Neuroscience letters

authors： Mitani A,Shimokouchi M,Nomura S

更新日期：1983-12-02 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis and blood vessel function. Recent evidence indicates that VEGF facilitates memory and learning through stimulating angiogenesis and neurogenesis in the rat hippocampal dendate gyrus. Abnormal regulation of VEGF expression has been reported ...

journal_title：Neuroscience letters

authors： Mateo I,Llorca J,Infante J,Rodríguez-Rodríguez E,Sánchez-Quintana C,Sánchez-Juan P,Berciano J,Combarros O

更新日期：2006-06-19 00:00:00

abstract：:The distribution of gamma-aminobutyric acid (GABA)-like immunoreactivity was studied in semithin sections through the inferior olivary complex in two baboon species. About 5% of the olivary neurons were GABA-immunoreactive. The GABA-immunoreactive neurons differed from the large majority of olivary neurons by their sm...

journal_title：Neuroscience letters

authors： Walberg F,Ottersen OP

更新日期：1989-06-19 00:00:00

abstract：:We report a sporadic case of tauopathy with unusual clinical and neuropathological features. The patient presented with progressive symmetric rigid-akinetic parkinsonism and dementia of the subcortical type. Magnetic resonance imaging of the brain revealed atrophy resembling multiple system atrophy. The level of cereb...

journal_title：Neuroscience letters

authors： Ohara S,Tsuyuzaki J,Oide T,Arai H,Higuchi S,Hasegawa M,Iwatsubo T

更新日期：2002-09-13 00:00:00

abstract：:With the use of an antiserum against human apelin-36, apelin-immunoreactivity (irAP) was detected in neurons and cell processes of the supraoptic nucleus (SO), paraventricular nucleus (PVH), accessory neurosecretory nuclei (Acc) and suprachiasmatic nucleus. Strongly labeled cells/processes were noted in the internal l...

journal_title：Neuroscience letters

authors： Brailoiu GC,Dun SL,Yang J,Ohsawa M,Chang JK,Dun NJ

更新日期：2002-07-26 00:00:00

abstract：:Changes in contingent negative variation (CNV), a brain-evoked potential related in arousal, as well as in serum triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), prolactin (PRL), cortisol and growth hormone (GH) levels were recorded in 12 male volunteers receiving either thyrotropin-releasing ...

journal_title：Neuroscience letters

authors： Strollo F,Amabile G,Fattapposta F,Strollo G,More M,Riondino G

更新日期：1988-11-11 00:00:00

abstract：:Electrical stimulation of the A1 noradrenergic region of the ventrolateral medulla produced synatic excitation (n = 19, 9%), inhibition (n = 5, 2%) or no effect (n = 184, 89%) in the activity of a total of 208 neurons in the subfornical organ (SFO) in male rats under urethane anesthesia. Almost all (n = 18) of the exc...

journal_title：Neuroscience letters

authors： Tanaka J,Mashiko N,Kawakami A,Hatakenaka S,Fujisawa S,Nomura M

更新日期：2002-10-25 00:00:00

abstract：:Leucine-enkephalin-like immunoreactive (ENK-LI) afferent fibers to the feline homologue of the Onuf's nucleus (pudendal motoneurons) originate mainly from lamina X of the sacral cord. They make synaptic contacts chiefly upon dendrites of pudendal motoneurons; the synaptic terminals most often contain pleomorphic synap...

journal_title：Neuroscience letters

authors： Konishi A,Itoh K,Sugimoto T,Yasui Y,Kaneko T,Takada M,Mizuno N

更新日期：1985-10-24 00:00:00