Analog of neuropeptide FF attenuates morphine tolerance.

Abstract:

:Previous studies suggest that neuropeptide FF (NPFF) plays a role in opiate dependence and subsequent abstinence syndrome. Endogenous NPFF also appears to play a role in opiate tolerance since third ventricle injection of IgG from NPFF antiserum selectively restores morphine sensitivity in morphine-tolerant rats. The NPFF analog, desamino YFLFQPQRamide (daY8Ra) has previously antagonized behavioral effects of NPFF and has attenuated morphine dependence. The present study assessed whether daY8Ra could similarly attenuate morphine tolerance. Third ventricle (i.c.v.) injection of daY8Ra restored the analgesic response to i.c.v. morphine in morphine-tolerant rats (radiant heat tail flick test). Saline injection failed to produce this effect. In opiate-naive rats, however, the same treatment with daY8Ra did not affect the analgesic response to i.c.v. morphine. Thus, daY8Ra appears to selectively restore morphine sensitivity in opiate-tolerant animals. These results further support the hypothesis that endogenous NPFF contributes to opiate tolerance.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Lake JR,Hebert KM,Payza K,Deshotel KD,Hausam DD,Witherspoon WE,Arcangeli KA,Malin DH

doi

10.1016/0304-3940(92)90078-l

keywords:

subject

Has Abstract

pub_date

1992-11-09 00:00:00

pages

203-6

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(92)90078-L

journal_volume

146

pub_type

杂志文章
  • The glycine site modulates NMDA-mediated changes of intracellular free calcium in cultures of hippocampal neurons.

    abstract::Recent evidence indicates that the N-methyl-D-aspartate (NMDA) receptor-channel complex contains a glycine subunit whose activation may be necessary for channel operation. It has been previously shown that stimulation of the NMDA receptor leads to an increase in intracellular ionic Ca2+ [( Ca2+]i); therefore, we exami...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90071-g

    authors: Oliver MW,Shacklock JA,Kessler M,Lynch G,Baimbridge KG

    更新日期:1990-07-03 00:00:00

  • Partial involvement of NMDA receptors and glial cells in the nociceptive behaviors induced by intrathecally administered histamine.

    abstract::The involvement of spinal glial cells in the nociceptive behaviors induced by 800 pmol of histamine was determined in mice. Histamine at 800 pmol injected intrathecally (i.t.) produced nociceptive behaviors, consisting of scratching, biting and licking. The nociceptive behaviors induced by histamine were significantly...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2011.02.038

    authors: Mizoguchi H,Komatsu T,Iwata Y,Watanabe C,Watanabe H,Orito T,Katsuyama S,Yonezawa A,Onodera K,Sakurada T,Sakurada S

    更新日期:2011-05-16 00:00:00

  • Long-term effects of dark rearing on a visually guided reaching movement in cats.

    abstract::The existence of long-term effects of dark-rearing on visuo-motor coordination is still controversial. In this study 2 dark-reared (DR) cats were trained, after 5-6 years of recovery, to perform a reaching movement towards a stationary or a moving target. The accuracy, and the reaction and movement times were evaluate...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90626-k

    authors: Fabre-Thorpe M,Levesque F,Gary-Bobo E

    更新日期:1990-10-16 00:00:00

  • Differential neurotrophic effects of apolipoprotein E in aged transgenic mice.

    abstract::The present study seeked to determine whether the neurodegenerative and cognitive alterations in aged apolipoprotein E-deficient mice are differentially reversed by transgenic overexpression of human apolipoprotein-E3 vs. apolipoprotein-E4 in the background of deficient endogenous apolipoprotein E. These studies showe...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(99)00243-8

    authors: Veinbergs I,Mallory M,Mante M,Rockenstein E,Gilbert JR,Masliah E

    更新日期:1999-04-23 00:00:00

  • Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells.

    abstract::We have identified the secretory cleavage site in the Alzheimer amyloid precursor (APP) in a non-transfected neuronal cell line, using cyanogen bromide digests of APP purified from medium conditioned by PC-12 cells which were differentiated to a neuronal phenotype. The results obtained are most consistent with proteol...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90775-o

    authors: Anderson JP,Esch FS,Keim PS,Sambamurti K,Lieberburg I,Robakis NK

    更新日期:1991-07-08 00:00:00

  • The effect of inflammatory stimuli on NMDA-related activation of glutamine synthase in human cultured astroglial cells.

    abstract::Removal of glutamate from the synaptic cleft by astroglial glutamine synthase (GS) is a crucial step in the regulation of glutamate turnover and metabolism, thus participating in endogenous neuroprotective processes occurring within brain tissues. Here we investigated on the effect of inflammatory cytokines on GS acti...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2004.09.079

    authors: Muscoli C,Visalli V,Colica C,Nisticò R,Palma E,Costa N,Rotiroti D,Nisticò G,Mollace V

    更新日期:2005-01-20 00:00:00

  • Modification of the monoaminergic neurotransmitters in frontal cortex and hippocampus by dietary trans alpha-linolenic acid in piglets.

    abstract::The effect of partial isomerization of dietary alpha-linolenic acid on the monoaminergic neurotransmitters in piglets was studied. After feeding the animals for 14 days with diets containing or not trans alpha-linolenic acid, neurotransmitters related to the monoaminergic function were quantified in the frontal cortex...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(02)00879-0

    authors: Acar N,Chardigny JM,Berdeaux O,Almanza S,Sébédio JL

    更新日期:2002-10-18 00:00:00

  • Progesterone and cocaine administration affect serotonin in the medial prefrontal cortex of ovariectomized rats.

    abstract::Due to the hypothetical role of ovarian hormones, estrogen and progesterone, in cocaine-induced behavioral activity and self-administration, this study investigated the effects of cocaine, estrogen, and progesterone administration on monoamine levels in the medial prefrontal cortex of ovariectomized hormone-treated ra...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01396-3

    authors: Perrotti LI,Beck KD,Luine VN,Quiñones V

    更新日期:2000-09-22 00:00:00

  • Acupuncture normalizes the release of accumbal dopamine during the withdrawal period and after the ethanol challenge in chronic ethanol-treated rats.

    abstract::Many studies have shown that acupuncture can contribute to the biochemical balance in the central nervous system and maintenance or recovery of homeostasis. It is well known that chronic administration of ethanol may produce depletion or sensitization of extracellular dopamine levels in the nucleus accumbens. The pres...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.10.043

    authors: Zhao RJ,Yoon SS,Lee BH,Kwon YK,Kim KJ,Shim I,Choi KH,Kim MR,Golden GT,Yang CH

    更新日期:2006-02-27 00:00:00

  • Enhancement of cell viability after treatment with polyunsaturated fatty acids.

    abstract::Attention-deficit/hyperactivity disorder (ADHD) is highly prevalent in children and adolescents and both environmental and genetic factors play major roles. Polyunsaturated fatty acids (PUFAs) are postulated to contribute to the development of the infant brain and an imbalance in these may increase the risk of ADHD. I...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2013.11.023

    authors: Bartl J,Walitza S,Grünblatt E

    更新日期:2014-01-24 00:00:00

  • A fractal analysis of pyramidal neurons in mammalian motor cortex.

    abstract::Pyramidal neurons in the mammalian cerebral cortex can be described by a fractal dimension (Mandelbrot, 1982), which is an objective, quantitative measure of the complexity of their soma/dendritic borders. In the cat, the fractal dimensions of lamina V cells, which include pyramidal tract neurons (PTN), indicate that ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90240-t

    authors: Porter R,Ghosh S,Lange GD,Smith TG Jr

    更新日期:1991-09-02 00:00:00

  • Cortical brain responses to semantic incongruity and syntactic violation in Italian language: an event-related potential study.

    abstract::The present experiment investigated cortical responses of native Italian subjects during reading of short sentences including semantic or morphosyntactic violations. Given the specificity of the Italian language in which the sequencing of words is relatively more free than in English or other languages, we investigate...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(01)02528-9

    authors: Angrilli A,Penolazzi B,Vespignani F,De Vincenzi M,Job R,Ciccarelli L,Palomba D,Stegagno L

    更新日期:2002-03-29 00:00:00

  • Upregulation of glutamatergic transmission in anterior cingulate cortex in the diabetic rats with neuropathic pain.

    abstract::Peripheral neuropathic pain is a common complication in the diabetic patients, and the underlying central mechanism remains unclear. Forebrain anterior cingulate cortex (ACC) is critically involved in the supraspinal perception of physical and affective components of noxious stimulus and pain modulation. Excitatory gl...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2014.03.038

    authors: Li W,Wang P,Li H

    更新日期:2014-05-07 00:00:00

  • Synchronous potentials and elevations in [K+]o in the adult rat entorhinal cortex maintained in vitro.

    abstract::Extracellular field-potential recordings and measurements of the extracellular concentration of potassium ([K+]o) were made in layers II and III of the adult rat entorhinal cortex in a slice preparation. Two types of spontaneous, synchronous potentials were induced by the convulsant drug 4-aminopyridine (4AP, 50 micro...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)11248-u

    authors: Lücke A,Nagao T,Köhling R,Avoli M

    更新日期:1995-02-13 00:00:00

  • O-phosphohomoserine, a naturally occurring analogue of phosphonate amino acid antagonists, is an N-methyl-D-aspartate (NMDA) antagonist in rat hippocampus.

    abstract::O-Phosphohomoserine, an analogue of the excitatory amino acid antagonist 2-amino-phosphonovalerate, has been synthesized and tested for activity as an excitatory amino acid antagonist. The tests were carried out on 500 micron thick slices of rat hippocampus superfused in vitro at 30 degrees C. Antidromic and orthodrom...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(86)90151-5

    authors: Connick JH,Heywood GC,Smith DA,Stone TW

    更新日期:1986-07-24 00:00:00

  • Treatment with dehydroepiandrosterone (DHEA) stimulates oxidative energy metabolism in the cerebral mitochondria. A comparative study of effects in old and young adult rats.

    abstract::The content of the neurosteroids, dehydroepiandrosterone (DHEA) in the brain decreases with aging. Also the oxidative energy metabolism is known to decrease with aging. Hence we examined the effects of treatment with DHEA (0.2 or 1.0 mg/kg body weight for 7 days) on oxidative energy metabolism in brain mitochondria fr...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2006.03.057

    authors: Patel MA,Katyare SS

    更新日期:2006-07-10 00:00:00

  • Serotonergic and non-serotonergic projections from the interpeduncular nucleus to the ventral hippocampus in the rat.

    abstract::The localization of serotonin and non-serotonin-containing cell bodies in the interpeduncular nucleus of the rat that project to the hippocampal formation was studied using the technique of retrograde tracing of Granular Blue and immunohistochemistry on the same sections. The results indicate that the caudal magnocell...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(84)90256-8

    authors: Groenewegen HJ,Steinbusch HW

    更新日期:1984-09-28 00:00:00

  • Expression of the junD proto-oncogene in the rat spinal cord and skin following noxious cutaneous ultraviolet irradiation.

    abstract::Noxious peripheral stimulation induces the expression of various proto-oncogenes in rat spinal neurons. However, proto-oncogene expression seems to differ depending on the mode of the stimulus. Here, we report that noxious cutaneous ultraviolet (UV) irradiation results in a nearly 8-fold increase in junD mRNA levels i...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90654-p

    authors: Gillardon F,Wiesner RJ,Zimmermann M

    更新日期:1992-02-17 00:00:00

  • Transient GABA-like immunoreactive axons in the corpus callosum of perinatal rats.

    abstract::During the early postnatal development of the rat, gamma-aminobutyric acid (GABA)-like immunoreactive axons were contained within the subcortical white matter. Some of the immunoreactive axons crossed the midline, while others followed a vertical or longitudinal trajectory within the lateral part of the corpus callosu...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(88)90003-1

    authors: Cobas A,Alvarez-Bolado G,Fairén A

    更新日期:1988-10-31 00:00:00

  • Coupling of muscarinic receptors to GTP proteins in postmortem human brain--alterations in Alzheimer's disease.

    abstract::The coupling of muscarinic agonist receptors to guanine nucleotide-binding (G) proteins was investigated in the frontal, temporal cortices and thalamus of control and Alzheimer brains by using carbachol in competition experiments with [3H]QNB. In the presence of GppNHp, the carbachol/[3H]QNB competition binding data s...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(93)90103-r

    authors: Warpman U,Alafuzoff I,Nordberg A

    更新日期:1993-02-05 00:00:00

  • Expression of intrinsic bursting properties in neurons of maturing sensorimotor cortex.

    abstract::Intrinsically bursting (IB) neurons, responding with a burst of action potentials to just threshold intracellular depolarizing current pulses, are encountered in layer V of mature rodent sensorimotor cortex. We report the results of intracellular recordings performed on neocortical slices obtained from immature rats b...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(93)90551-u

    authors: Franceschetti S,Buzio S,Sancini G,Panzica F,Avanzini G

    更新日期:1993-11-12 00:00:00

  • Dissociating love-related attention from task-related attention: an event-related potential oddball study.

    abstract::The present event-related potential (ERP) study was conducted to investigate the P3 component in response to love-related stimuli while controlling for task-related factors, and to dissociate the influences of both love-related and task-related attention on the P3 amplitude. In an oddball paradigm, photographs of belo...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2007.11.044

    authors: Langeslag SJ,Franken IH,Van Strien JW

    更新日期:2008-02-06 00:00:00

  • Granulocyte-colony stimulating factor ameliorates irradiation-induced suppression of hippocampal neurogenesis in adult mice.

    abstract::Granulocyte-colony stimulating factor (G-csf) is a member of the hematopoietic growth factor family and demonstrates neuroprotective functions in neurodegenerative diseases. This study evaluated the radioprotective effects of G-csf in the suppression of hippocampal neurogenesis in adult mice undergoing irradiation. Th...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2010.09.041

    authors: Kim JS,Yang M,Jang H,Oui H,Kim SH,Shin T,Jang WS,Lee SS,Moon C

    更新日期:2010-12-03 00:00:00

  • Effects of voluntary exercise on anxiety-like behavior and voluntary morphine consumption in rat pups borne from morphine-dependent mothers during pregnancy.

    abstract::Exposure to morphine during pregnancy produced long-term effects in offspring behaviors. Recent studies have shown that voluntary exercise decreases the severity of anxiety behaviors in both morphine-dependent and withdrawn rats. Thus, the aims of the present study were to examine whether maternal exercise decreases p...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2014.06.026

    authors: Haydari S,Miladi-Gorji H,Mokhtari A,Safari M

    更新日期:2014-08-22 00:00:00

  • The effect of static and dynamic visual gestures on stuttering inhibition.

    abstract::The aim of the study was to evaluate the role of steady-state and dynamic visual gestures of vowels in stuttering inhibition. Eight adults who stuttered recited sentences from memory while watching video presentations of the following visual speech gestures: (a) a steady-state /u/, (b) dynamic production of /a-i-u/, (...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2011.01.049

    authors: Guntupalli VK,Nanjundeswaran C,Kalinowski J,Dayalu VN

    更新日期:2011-03-29 00:00:00

  • Inhibition of nitric oxide synthase influences the activity of striatal neurons in the rat.

    abstract::The activity of single units in the striatum of urethane-anesthetized rats was recorded before and after the systemic administration of 7-nitro-indazole (7-NI; 50 mg/kg intraperitoneally), a selective inhibitor of neuronal nitric oxide (NO) synthase. Two neuronal types were clearly distinguishable electrophysiological...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(02)00270-7

    authors: Sardo P,Ferraro G,Di Giovanni G,Galati S,La Grutta V

    更新日期:2002-06-14 00:00:00

  • Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury.

    abstract::Traumatic brain injury is accompanied by glial cell activation around the site of the injury. In this study, we investigated the role of toll-like receptor 2 (TLR2) in glial cell activation using a stab-wound injury (SWI) model with TLR2 knock-out mice. Penetration of a normal mouse brain with a 26-G needle using a st...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2007.11.057

    authors: Park C,Cho IH,Kim D,Jo EK,Choi SY,Oh SB,Park K,Kim JS,Lee SJ

    更新日期:2008-01-31 00:00:00

  • A study of GABAergic system in Scrapie-infected hamsters after striatal microinoculation of the agent.

    abstract::Experimental Scrapie in hamster is a simple, reproducible model of prion diseases that occur in humans and animals. Stereotaxic microinoculation (0.5 microliter) of the agent (263 K) into a specific cerebral structure (striatum) in hamster, previously developed in our group, gives the opportunity to further investigat...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(93)90366-s

    authors: Grégoire N,Lebrun F,Fahn L,Salamon G,Nicoli J

    更新日期:1993-12-12 00:00:00

  • Direct effects of the anabolic/androgenic steroids, stanozolol and 17 alpha-methyltestosterone, on benzodiazepine binding to the. gamma-aminobutyric acid(a) receptor.

    abstract::Various exogenous and endogenous steroids have been demonstrated to have both enhancing and inhibiting effects on ligand binding to the gamma-aminobutyric acid(A) receptor (GABAA receptor) in previous studies. In the present study we have explored the possibility that an additional class of synthetic steroidal compoun...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)11445-3

    authors: Masonis AE,McCarthy MP

    更新日期:1995-04-07 00:00:00

  • Prostacyclin synthase is localized in rat, bovine and human neuronal brain cells.

    abstract::Using a new polyclonal antibody against prostacyclin (PGI2)-synthase this enzyme was shown to be present in neuronal cells of bovine, rat and human brain, most abundantly in Purkinje cells of the cerebellum and cortical neurons, but not in glial cells. Western blots confirmed the specificity of the antibody and applie...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(99)00558-3

    authors: Mehl M,Bidmon HJ,Hilbig H,Zilles K,Dringen R,Ullrich V

    更新日期:1999-08-27 00:00:00