Abstract:
:Advanced aging is accompanied by a decline in visuospatial attention. Previous neuroimaging and electrophysiological studies have demonstrated dysfunction in specific brain areas related to visuospatial attention. However, it is still unclear how the functional connectivity between brain regions causes the decline of visuospatial attention. Here, we combined task and rest functional magnetic resonance imaging (fMRI) to investigate the age-dependent alterations of resting-state functional connectivity within the task-related network. Twenty-three young subjects and nineteen elderly subjects participated in this study, and a modified Posner paradigm was used to define the region of interest (ROI). Our results showed that a marked reduction in the number of connections occurred with age, but this effect was not uniform throughout the brain: while there was a significant loss of communication in the anterior portion of the brain and between the anterior and posterior cerebral cortices, communication in the posterior portion of the brain was preserved. Moreover, the older adults exhibited weakened resting-state functional connectivity between the supplementary motor area and left anterior insular cortex. These findings suggest that, the disrupted functional connectivity of the brain network for visuospatial attention that occurs during normal aging may underlie the decline in cognitive performance.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Li Y,Li C,Wu Q,Xu Z,Kurata T,Ohno S,Kanazawa S,Abe K,Wu Jdoi
10.1016/j.neulet.2015.03.047subject
Has Abstractpub_date
2015-06-15 00:00:00pages
13-8eissn
0304-3940issn
1872-7972pii
S0304-3940(15)00240-2journal_volume
597pub_type
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