Unaltered alpha-synuclein blood levels in juvenile Parkinsonism with a parkin exon 4 deletion.

abstract：:Patients with Parkinson's disease develop motor disturbances often accompanied by peripheral autonomic dysfunctions, including gastrointestinal disorders, such as dysphagia, gastric stasis and constipation. While the mechanisms subserving enteric autonomic dysfunctions are not clearly understood, they may involve the ...

journal_title：Neuroscience letters

authors： Blandini F,Balestra B,Levandis G,Cervio M,Greco R,Tassorelli C,Colucci M,Faniglione M,Bazzini E,Nappi G,Clavenzani P,Vigneri S,De Giorgio R,Tonini M

更新日期：2009-12-31 00:00:00

abstract：:A two-stage model of sustained neural activity in the prefrontal cortex is proposed in order to simulate feature binding and capacity limits in visual working memory. In the first stage, object features are stored in parallel network layers without explicit conjunctions. A second stage binds features into integrated o...

journal_title：Neuroscience letters

authors： Domijan D

更新日期：2003-10-23 00:00:00

abstract：:The frog horizontal monocular optokinetic nystagmus (OKN) is asymmetrical, the temporal-nasal (T-N) stimulation being the sole stimulation efficient to evoke the reflex, the nasal-temporal (N-T) component being almost absent. Coil recordings showed that, in adult animals, prolonged monocular visual deprivation by unil...

journal_title：Neuroscience letters

authors： Jardon B,Bonaventure N

更新日期：1992-03-30 00:00:00

abstract：:GABAergic modulation of enkephalin, substance P and glutamic acid decarboxylase (GAD67) gene expression and the alterations induced by dopamine receptor blockade were studied in the rat striatum. Following subchronic treatment with the GABA-A agonist muscimol, the GABA-B agonist baclofen or the GABA transaminase inhib...

journal_title：Neuroscience letters

authors： Jolkkonen J,Jenner P,Marsden CD

更新日期：1994-10-24 00:00:00

abstract：:Neuraxial analgesia is often provided using a mixture of local anesthetics and opioids. This combination of agents provides better pain relief and is generally associated with fewer side effects than when either drug is given alone. Local anesthetics have been shown to alter signaling of other G protein-coupled recept...

journal_title：Neuroscience letters

authors： Komai H,McDowell TS

更新日期：2007-05-18 00:00:00

abstract：:Surround inhibition (SI) is a neural mechanism to focus neuronal activity and facilitate selective motor execution (ME). The aim of the present study was to investigate whether SI is also generated during motor imagery (MI). Furthermore, we investigated whether the extent of SI during MI depends on the strength of SI ...

journal_title：Neuroscience letters

authors： Aoyama T,Kaneko F,Ohashi Y,Nagata H

更新日期：2016-08-26 00:00:00

abstract：:Retinal progenitor cells (RPCs) are an excellent resource for retinal replacement therapy, because they show enormous potential to differentiate into retinal-specific cell types. While the differentiating influence of serum has long been appreciated, the effects of serum concentration on RPC differentiation into speci...

journal_title：Neuroscience letters

authors： Hu Y,Ji J,Xia J,Zhao P,Fan X,Wang Z,Zhou X,Luo M,Gu P

更新日期：2013-02-08 00:00:00

abstract：:Activation of the medial septum (MS) enhances the synchronized firing of pyramidal cells in the hippocampus. At least two distinct mechanisms might be recruited in this process: GABAergic inhibition of hippocampal inhibitory interneurons and cholinergic enhancement of pyramidal cell excitability. In the present study,...

journal_title：Neuroscience letters

authors： Ovsepian SV

更新日期：2006-01-23 00:00:00

abstract：:Normal-learning children (NL) and children with learning disabilities (LD) reported their perceptions of unisensory (auditory or visual), concordant audiovisual (e.g. visual /apa/ and auditory /apa/) and conflicting (e.g. visual /aka/ and auditory /apa/) speech stimuli in quiet and noise (0 dB and -12 dB signal-to-noi...

journal_title：Neuroscience letters

authors： Hayes EA,Tiippana K,Nicol TG,Sams M,Kraus N

更新日期：2003-11-06 00:00:00

abstract：:Metabotropic glutamate receptors are selectively activated by 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). [3H]Glutamate binding sites in rat brain membranes were characterized in the presence of (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, and N-methyl-D-aspartate (N...

journal_title：Neuroscience letters

authors： Schoepp DD,True RA

更新日期：1992-09-28 00:00:00

abstract：:Regeneration of reduced nicotinamide adenine dinucleotide phosphate (NADPH) is essential for the activity of glutathione redox cycling during cellular peroxide detoxification. In order to test for a function of astroglial glycogen to serve as endogenous precursor for glucose-6-phosphate, the substrate for the regenera...

journal_title：Neuroscience letters

authors： Rahman B,Kussmaul L,Hamprecht B,Dringen R

更新日期：2000-09-01 00:00:00

abstract：:Aβ-mediated oxidative stress damage is considered a direct cause of Alzheimer's disease (AD). Therefore, drugs that have been developed to block oxidative stress are considered effective for AD treatment. Isosilybin is a flavonoid compound extracted from Silybum marianum, and it has been confirmed to have many pharmac...

journal_title：Neuroscience letters

authors： Zhou J,Chao G,Li Y,Wu M,Zhong S,Feng Z

更新日期：2016-10-06 00:00:00

abstract：:HS-142-1 is a novel non-peptide antagonist for atrial natriuretic peptide (ANP) receptor. The effect of HS-142-1 on the cyclic GMP production elicited by natriuretic peptides in neuronal cell lines, PC12 and NG108-15 was examined. Natriuretic peptides such as ANP, brain natriuretic peptide (BNP), and C-type natriureti...

journal_title：Neuroscience letters

authors： Toki S,Morishita Y,Sano T,Matsuda Y

更新日期：1992-01-20 00:00:00

abstract：:To investigate the relationship between apolipoprotein E (APOE) polymorphisms and the severity of traumatic brain injury (TBI) in acute stage in the cohort of mainland Chinese patients. We prospectively identified admissions to the two neurosurgical departments for head injury. A total of 110 subjects with TBI (80 mal...

journal_title：Neuroscience letters

authors： Jiang Y,Sun X,Xia Y,Tang W,Cao Y,Gu Y

更新日期：2006-11-13 00:00:00

abstract：:GABA transaminase activity is reduced in autopsied putamen samples from patients dying with Huntington's disease. Its activity is also reduced in the striatum of rats previously lesioned with kainic acid. In both cases, the reduction in GABA transaminase activity is comparable with the reduction in glutamate decarboxy...

journal_title：Neuroscience letters

authors： Carter CJ

更新日期：1984-08-10 00:00:00

abstract：:In this study non-linear and linear global electroencephalogram (EEG) changes during a visual working memory task were studied using a separate analysis of theta, lower alpha and upper alpha band filtered data. EEGs were recorded in 21 healthy subjects (62.5 year; SD 2.1; 12 females, nine males) during an eyes-closed ...

journal_title：Neuroscience letters

authors： Stam CJ

更新日期：2000-06-02 00:00:00

abstract：:Peroxidase-antiperoxidase (PAP) immunocytochemistry at the electron microscopic level was used to describe the fine structural characteristics of vascular connections between vasopressin (VP)-immunoreactive neuronal elements and cerebral microvessels in the rat. In the majority of connections, somata or neural process...

journal_title：Neuroscience letters

authors： Jójárt I,Joó F,Siklós L,László FA

更新日期：1984-10-12 00:00:00

abstract：:Human electroencephalogram (EEG) consists of complex aperiodic oscillations that are assumed to indicate underlying neural dynamics such as the number and degree of independence of oscillating neuronal networks. EEG complexity can be estimated using measures derived from nonlinear dynamic systems theory. Variations in...

journal_title：Neuroscience letters

authors： Anokhin AP,Müller V,Lindenberger U,Heath AC,Myers E

更新日期：2006-04-10 00:00:00

abstract：:Melatonin is the principle hormonal product of the pineal gland. It is secreted with a robust daily rhythm, peaking near the middle of the night. During the daytime, concentrations remain very low, as exposure to light robustly suppresses its secretion. The regulation of melatonin by light is well-characterized, but a...

journal_title：Neuroscience letters

authors： Bedrosian TA,Herring KL,Walton JC,Fonken LK,Weil ZM,Nelson RJ

更新日期：2013-05-10 00:00:00

abstract：:Noradrenergic fibers from the locus ceruleus were identified in close proximity to brain microvessels, and adrenoceptors exist in isolated brain capillaries. Yet, proof of innervation of brain microvessels by locus ceruleus remains elusive. We now demonstrate increased density of beta-adrenoceptors by pindolol binding...

journal_title：Neuroscience letters

authors： Kalaria RN,Stockmeier CA,Harik SI

更新日期：1989-02-13 00:00:00

abstract：:Total RNA was purified from rat forebrain at different postnatal ages and analyzed by Northern blot using a specific neurotensin receptor RNA probe. The rat neurotensin receptor mRNA was present in high amount during the first 10 days of life. Thereafter, it rapidly decreased and was undetected after 20 days. [3H]neur...

journal_title：Neuroscience letters

authors： Hermans E,Jeanjean AP,Laduron PM,Octave JN,Maloteaux JM

更新日期：1993-07-09 00:00:00

abstract：:The possibility for the induction of long-lasting synaptic plasticity by the potassium channel blocker tetraethylammonium (TEA) was investigated in adult rat motor cortex in vitro. Brief application of TEA (25 mM) resulted in a long-term potentiation (LTP(K)) of field potentials evoked in layer V intralaminar connecti...

journal_title：Neuroscience letters

authors： Jagodzinski P,Hess G

更新日期：2001-01-26 00:00:00

abstract：:Autism spectrum disorder (ASD) is a group of developmental disorders characterized by social interaction deficits, communication impairments, and stereotyped and repetitive behaviors. Additionally, impairments in the GABAergic circuitry have been associated with ASD. Several studies have shown that dysfunction of the ...

journal_title：Neuroscience letters

authors： Varman DR,Soria-Ortíz MB,Martínez-Torres A,Reyes-Haro D

更新日期：2018-11-20 00:00:00

abstract：:Removal of glutamate from the synaptic cleft by astroglial glutamine synthase (GS) is a crucial step in the regulation of glutamate turnover and metabolism, thus participating in endogenous neuroprotective processes occurring within brain tissues. Here we investigated on the effect of inflammatory cytokines on GS acti...

journal_title：Neuroscience letters

authors： Muscoli C,Visalli V,Colica C,Nisticò R,Palma E,Costa N,Rotiroti D,Nisticò G,Mollace V

更新日期：2005-01-20 00:00:00

abstract：:The role of the late afterhyperpolarization (late AHP) in the firing properties of lamprey spinal neurons was tested by bath application of apamin, a selective blocker of the sk calcium-dependent potassium current. Intracellular recordings of identified motoneurons and interneurons were made with micropipette electrod...

journal_title：Neuroscience letters

authors： Meer DP,Buchanan JT

更新日期：1992-08-31 00:00:00

abstract：:Recent evidence suggests that among the factors that lead to neurodegenerative changes in Parkinson's disease are stimulation of lipid peroxidation and deficiency of glutathione and glutathione peroxidase in substantia nigra. We have investigated the effect of neurodegenerative changes on plasma and erythrocytes of pa...

journal_title：Neuroscience letters

authors： Kilinç A,Yalçin AS,Yalçin D,Taga Y,Emerk K

更新日期：1988-05-03 00:00:00

abstract：:We performed an electron microscopic study in layers II-III of S-1 in rats, using postembedding immunogold histochemistry to compare the synaptic distribution of N-methyl D-aspartate (NMDA) receptors (assessed with an antibody for the NMDAR1 subunit) with that of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (A...

journal_title：Neuroscience letters

authors： Kharazia VN,Weinberg RJ

更新日期：1997-11-28 00:00:00

abstract：:The role of the lateral hypothalamus (LHT) in the regulation of feeding behavior has long been established. The major contribution of LHT glucose-sensitive neurons, activated by low glucose concentration, is well accepted. Two peptidergic neuron populations, whose perikarya are exclusively located within this area, ha...

journal_title：Neuroscience letters

authors： Bahjaoui-Bouhaddi M,Fellmann D,Bugnon C

更新日期：1994-02-28 00:00:00

abstract：:Push-pull cannulae were acutely positioned through previously implanted guides in the globus pallidus of unanesthetized freely moving cats and rats. During slow-flow perfusions, enkephalin release was detected in resting conditions and increased more than 3-fold when both 50 mM K+ and 1.8 mM Ca2+ were present in the p...

journal_title：Neuroscience letters

authors： Bayon A,Shoemaker WJ,Lugo L,Azad R,Ling N,Drucker-Colin RR,Bloom FE

更新日期：1981-06-12 00:00:00

abstract：:We previously identified a novel molecule "Shati/Nat8l" from the nucleus accumbens of mice. However, the physiological roles of the SHATI protein are not clear. To investigate the effect of SHATI on the central nervous system and behavior, we studied knockout mice of this protein. We carried out various behavior tests...

journal_title：Neuroscience letters

authors： Furukawa-Hibi Y,Nitta A,Fukumitsu H,Somiya H,Toriumi K,Furukawa S,Nabeshima T,Yamada K

更新日期：2012-09-27 00:00:00