The effect of age on muscarinic receptor transcripts in rat brain.

abstract：BACKGROUND:Brain function relies on the capacity of neurons to locally modulate each other at the level of synapses. Therefore, the exosomal pathway may constitute a well-designed mechanism for local and systemic interneuronal transfer of information within functional brain networks. Exosomes bind to and are endocytose...

journal_title：Neuroscience letters

authors： Yu X,Abdul M,Fan BQ,Zhang L,Lin X,Wu Y,Fu H,Lin Q,Meng H

更新日期：2020-04-01 00:00:00

abstract：:'Clipsin' and other peptide bond hydrolase activities that appear to be integral membrane proteins, including two implicated in the formation of the histological hallmarks of Alzheimer's disease, were assayed in the frontal and parietal cortex from a large (n = 45) series of postmortem human brains. Tissues were extra...

journal_title：Neuroscience letters

authors： Stratmann GC,Webster MT,Francis PT,Procter AW,Bowen DM

更新日期：1992-08-31 00:00:00

abstract：:Fluorescent tracers (Nuclear Yellow, True Blue, Fast Blue) were injected, in various combinations, into the globus pallidus and substantia nigra in three marmosets. Examination of perikarya in the ipsilateral neostriatum, well removed from pallidal injection sites, revealed that the predominant pattern was of single-l...

journal_title：Neuroscience letters

authors： Féger J,Crossman AR

更新日期：1984-08-24 00:00:00

abstract：:Carrageenan-induced inflammation of the rat hindpaw has been used as a model for persistent pain of inflammatory origin. The induction of inflammation resulting from carrageenan injection in the rat hindpaw has been shown to elicit an increase in the antinociceptive potency of morphine, an effect postulated to be rela...

journal_title：Neuroscience letters

authors： Ossipov MH,Kovelowski CJ,Porreca F

更新日期：1995-01-30 00:00:00

abstract：:The cerebellar Purkinje cell is a major site for neurosteroid formation. We have demonstrated recently that the Purkinje cell actively produces sex steroids, such as estradiol and progesterone, de novo from cholesterol only during rat neonatal life, when cerebellar cortical formation occurs. We have further demonstrat...

journal_title：Neuroscience letters

authors： Shikimi H,Sakamoto H,Mezaki Y,Ukena K,Tsutsui K

更新日期：2004-07-01 00:00:00

abstract：:Agonist-induced turnover or release of inositolphosphates (IP) was studied in the dorsal and the ventral hippocampus 24 h, 1 month, and 3 months after the last electrical stimulus of kindled rats. A significant increase in acetylcholine (ACh)-stimulated IP turnover was observed in dorsal, but not ventral, hippocampus ...

journal_title：Neuroscience letters

authors： Zhang WQ,Tandon P,Sobotka TJ,Hong JS,Tilson HA

更新日期：1990-10-02 00:00:00

abstract：:To investigate injury-induced alterations of purinergic P2Y receptor-mediated calcium responses in glial (Müller) cells of the rabbit retina, neural retinae were experimentally detached from the pigment epithelium. The ATP-evoked calcium responses were recorded in the endfeet of glial cells at the vitread surface of r...

journal_title：Neuroscience letters

authors： Uckermann O,Uhlmann S,Weick M,Pannicke T,Francke M,Reichenbach A,Wiedemann P,Bringmann A

更新日期：2003-02-27 00:00:00

abstract：:Cultured embryonic mouse olfactory bulb cells formed asymmetric, symmetric, axodendritic, and dendrodendritic synapses. These neurons contained electron lucent, dense core, and coated vesicles. Dense core and coated vesicles had an average diameter of 71 and 80 nm, respectively. Two statistically different populations...

journal_title：Neuroscience letters

authors： Fracek SP Jr,Guo L,Schafer R

更新日期：1994-04-11 00:00:00

abstract：:The effect of antagonists on N-methyl-D-aspartate (NMDA)-induced response was investigated in isolated nucleus tractus solitarii (NTS) neurons freshly isolated from the rat using a conventional pathclamp technique. The NMDA-induced inward current consisted of an initial peak followed by a steady-state component. The c...

journal_title：Neuroscience letters

authors： Nakagawa T,Shirasaki T,Tateishi N,Murase K,Akaike N

更新日期：1990-05-31 00:00:00

abstract：:Survivors of bacterial meningitis frequently suffer from long-term sequelae, particularly from learning and memory deficits. For this reason, spatial memory and learning was studied in a mouse model of ceftriaxone-treated Streptococcus pneumoniae meningitis. Persistent deficits of spatial learning despite normal motor...

journal_title：Neuroscience letters

authors： Wellmer A,Noeske C,Gerber J,Munzel U,Nau R

更新日期：2000-12-22 00:00:00

abstract：:To assess the role of nasal/tracheal (N/T) breathing in the respiratory patterning of the olfactory bulb (OB) neurons, the activity of 21 units was recorded in 6 anesthetized rats set with a cannula enabling reversible tracheotomy: the rats could inhalate either through nasal pathways or through trachea directly. Shif...

journal_title：Neuroscience letters

authors： Ravel N,Pager J

更新日期：1990-07-31 00:00:00

abstract：:Upregulation of cyclin-dependent kinase 5 (Cdk5) after chronic cocaine administration has led to speculation that Cdk5 plays an important role in drug addiction. However, as Cdk5 involvement is implicated in a variety of neural events, including neuronal development, synaptic plasticity and learning, a specific role i...

journal_title：Neuroscience letters

authors： Seiwell AP,Reveron ME,Duvauchelle CL

更新日期：2007-04-24 00:00:00

abstract：:Fetal intrauterine growth restriction generates chronic hypoxia due to placental insufficiency. Despite the hemodynamic process of blood flow, redistributions are taking place in key organs such as the fetal brain during intrauterine growth restriction, in order to maintain oxygen and nutrients supply. The risk of sho...

journal_title：Neuroscience letters

authors： Hernández-Andrade E,Cortés-Camberos AJ,Díaz NF,Flores-Herrera H,García-López G,González-Jiménez M,Santamaría A,Molina-Hernández A

更新日期：2015-01-01 00:00:00

abstract：:The mechanisms underlying alterations in brain functions in response to physical exercise are not fully understood. The present study examined the central effect of irisin, a 112 amino acid polypeptide hormone secreted from the skeletal muscle after exercise, on the locomotion in rats. Central administration of irisin...

journal_title：Neuroscience letters

authors： Zhang W,Chang L,Zhang C,Zhang R,Li Z,Chai B,Li J,Chen E,Mulholland M

更新日期：2015-05-19 00:00:00

abstract：:Noise-induced hearing loss (NIHL) severely impacts the quality of life of affected individuals. Oxidative stress resulting from noise exposure is a significant cause of NIHL. Although histone deacetylase (HDAC) inhibitors were shown to protect against NIHL, the underlying mechanism remains unclear, and it is not known...

journal_title：Neuroscience letters

authors： Yang DH,Xie J,Liu K,Peng Z,Guo JY,Yu SK,Wang GP,Gong SS

更新日期：2017-11-01 00:00:00

abstract：:We have studied the electrophysiological properties of hippocampal neurons grown on surfaces of organic thin films formed on glass or silicon substrates and on microelectronic device surfaces in culture. Hippocampal neurons were dissociated from embryonic rats and plated on substrates chemically modified with laminin ...

journal_title：Neuroscience letters

authors： Offenhäusser A,Sprössler C,Matsuzawa M,Knoll W

更新日期：1997-02-14 00:00:00

abstract：:Experiments were done in conscious rats to investigate the effect of intravenous infusion of hypertonic saline on the induction of the protein Fos, in brainstem neurons. Neurons containing Fos-like immunoreactivity were observed in the caudal nucleus of the solitary tract (NTS), the caudal and rostral ventrolateral me...

journal_title：Neuroscience letters

authors： Hochstenbach SL,Solano-Flores LP,Ciriello J

更新日期：1993-08-20 00:00:00

abstract：:Following ventral root injury-filling with horseradish peroxidase at sacral spinal levels S1, S2, and S3, small fascicles of axons can be observed to enter the ventral portion of lamina I and arborize primarily in the dorsolateral region just medial to the tract of Lissauer (TL). Some axons enter the TL and turn in a ...

journal_title：Neuroscience letters

authors： Beattie MS,Bresnahan JC,Mawe GM,Finn S

更新日期：1987-04-23 00:00:00

abstract：:Odor-induced oscillatory signals have been reported in odor discrimination in various insects. To understand dynamic olfactory coding in the first order olfactory center, the antennal lobe, localization of oscillatory signals was investigated using an optical recording technique with a voltage-sensitive dye. We presen...

journal_title：Neuroscience letters

authors： Okada K,Kanzaki R

更新日期：2001-12-28 00:00:00

abstract：:Interleukin-1 beta (IL-1 beta), interleukin-2 (IL-2), and interleukin-6 (IL-6) were measured in the cerebrospinal fluid (CSF) and plasma of 12 control subjects, 11 sporadic Alzheimer's disease (AD) and 22 de novo Parkinson's disease (PD) patients using high sensitivity enzyme-linked immunosorbent assays (ELISA). IL-1 ...

journal_title：Neuroscience letters

authors： Blum-Degen D,Müller T,Kuhn W,Gerlach M,Przuntek H,Riederer P

更新日期：1995-12-29 00:00:00

abstract：:Several lines of evidence suggest that dopamine exerts a chronic inhibitory action on GABAergic cells in the striatum, and striatal glutamic acid decarboxylase (GAD) mRNA levels are increased after ipsilateral dopaminergic denervation. In the present study we have used GAD immunocytochemistry to assess whether dopamin...

journal_title：Neuroscience letters

authors： Segovia J,Armstrong DM,Benzing WC,Hornby PJ

更新日期：1991-01-28 00:00:00

abstract：:Lithium has been successfully employed therapeutically for treatment of bipolar depressive illness; however, its mechanism of action is poorly understood. Recently, it has been demonstrated by us that lithium can prevent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) dopaminergic neurotoxicity in mice. From analy...

journal_title：Neuroscience letters

authors： Arraf Z,Amit T,Youdim MB,Farah R

更新日期：2012-05-10 00:00:00

abstract：:Neurotrophic factors regulate neuronal survival and differentiation and control neurite outgrowth by binding to tyrosine kinase receptors, the Trks, and a tumor necrosis factor (TNF) receptor-like molecule, p75 neurotrophin receptor. A proinflammatory cytokine, TNF, also affects survival and apoptotic death in neurona...

journal_title：Neuroscience letters

authors： Furuno T,Nakanishi M

更新日期：2006-01-16 00:00:00

abstract：:The effects of the N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists MK-801 and NBQX, respectively, on salivary secretion and retching induced by vagal stimulation were studied in decerebrate dogs. Vagal stimulation induced an increase in salivary secretion and fictive retching. Intra-4th ventricular appli...

journal_title：Neuroscience letters

authors： Furukawa N,Hatano M,Fukuda H,Koga T

更新日期：1998-12-11 00:00:00

abstract：:8-Hydroxy-2-[di-n-propylamino]-tetralin) (8-OH-DPAT), a 5-HT1A/7 receptor agonist, has a chronobiological effect on the circadian system. To identify how the 8-OH-DPAT exerts this effect, we specifically destroyed the serotonergic (5-HT) fibres connecting the median raphe nuclei (RN) to the suprachiasmatic nuclei (SCN...

journal_title：Neuroscience letters

authors： Schuhler S,Saboureau M,Pitrosky B,Pévet P

更新日期：1998-10-30 00:00:00

abstract：:Peptide histidine-isoleucine (PHI) immunoreactivity was located in amacrine-like cells in adult rat retina by use of immunohistochemical techniques. Immunoreactive somata were found in the proximal part of the inner nuclear layer. From these somata, processes could be followed into the inner plexiform layer. The termi...

journal_title：Neuroscience letters

authors： Mikkelsen JD,Larsen JN,Fahrenkrug J,Møller M

更新日期：1987-08-31 00:00:00

abstract：:Using retrograde transport of Fluoro-Gold (FG) combined with immunofluorescence for phenylethanolamine-N-methyltransferase (PNMT), we have examined afferents to the nucleus locus coeruleus (LC) from the rostral ventrolateral medulla (nucleus paragigantocellularis; PGi) in rats sustaining lesions of the medullary adren...

journal_title：Neuroscience letters

authors： Astier B,Van Bockstaele EJ,Aston-Jones G,Pieribone VA

更新日期：1990-10-16 00:00:00

abstract：:The Rose Bengal model in rats is widely used to study brain plasticity, functional recovery and restorative therapies. The present study evaluated temporal profiles of hemorrhage and edema by magnetic resonance imaging (MRI) in rats in relation to sensorimotor impairment after photochemically induced cortical infarct....

journal_title：Neuroscience letters

authors： Jolkkonen J,Jokivarsi K,Laitinen T,Gröhn O

更新日期：2007-11-27 00:00:00

abstract：:A two pulse technique was used to study the decay of mechanical activation in TTX poisoned mouse extensor digitorum longus (EDL) and soleus muscle fibres. A two microelectrode point voltage clamp technique was used with visual endpoint determination of the threshold potential for activation. The excitatory effect of a...

journal_title：Neuroscience letters

authors： Dulhunty AF

更新日期：1979-10-01 00:00:00

abstract：:It is believed that subjects with high trait anxiety levels tend to present state anxiety reactions with greater intensity than individuals with low trait anxiety levels. In order to verify if this premise is valid for animal models of anxiety, the present work investigated the possible correlation between two behavio...

journal_title：Neuroscience letters

authors： Goes TC,Antunes FD,Teixeira-Silva F

更新日期：2009-02-06 00:00:00