Downregulation of mu-opioid receptor mRNA in the mediobasal hypothalamus of the female guinea pig following morphine treatment.

abstract：:We recently described dextran derivatives (RGTA) which stimulate tissue repair in several in vivo models. One of them, RGTA11, has been shown to accelerate crush-induced regeneration and reinnervation of rat EDL and Soleus muscles. In this study we wanted to know if RGTA11 alters the pattern of myosin heavy chain expr...

journal_title：Neuroscience letters

authors： Aamiri A,Butler-Browne GS,Martelly I,Barritault D,Gautron J

更新日期：1995-12-15 00:00:00

abstract：:Opioids are used in clinical practice to relieve moderate to severe pain. Prolonged use of opioids can lead to a situation of analgesic tolerance and dependence. Several mechanisms are involved in the tolerance to analgesic opioids, including desensitization or internalization of the opioid receptor, elevation of cAMP...

journal_title：Neuroscience letters

authors： Shirooie S,Esmaeili J,Sureda A,Esmaeili N,Mirzaee Saffari P,Yousefi-Manesh H,Dehpour AR

更新日期：2020-01-18 00:00:00

abstract：:The present study was designed to test the hypothesis that alpha-tocopherol (Vit. E) and pyrrolidine dithiocarbamate (PDTC) might exert direct effects on alcohol-induced contractions of canine basilar cerebral arteries. After precontraction of arterial ring segments with ethanol, PDTC (10(-8)-10(-6) M) and Vit. E (10(...

journal_title：Neuroscience letters

authors： Li W,Zheng T,Altura BT,Altura BM

更新日期：2001-03-30 00:00:00

abstract：:Recent reports have suggested that variants in the sortilin-related receptor gene (SORL1) increase the risk of late onset Alzheimer's disease (AD) in Northern European, Hispanic, African-American and Isreali-Arab populations. SORL1 directs trafficking of amyloid precursor protein (APP) and under-expression of SORL1 ma...

journal_title：Neuroscience letters

authors： Lee JH,Chulikavit M,Pang D,Zigman WB,Silverman W,Schupf N

更新日期：2007-09-25 00:00:00

abstract：:Recently we have demonstrated the presence of a gap in the avian retinotectal projection, that corresponds with the locus of retinotopic representation of the elongated optic nerve head. The present report describes an equivalent gap in the optic neuropiles of the avian ventral geniculate nucleus and griseum tectalis ...

journal_title：Neuroscience letters

authors： Puelles L,Martinez S,Martinez-de-la-Torre M

更新日期：1988-02-15 00:00:00

abstract：:The axonal efferents of neurons of the supraoptic nucleus area were studied by radioautography in the rat after discrete stereotaxic injections of [3H]leucine into this nucleus. Beside a densely labeled pathway running from the nucleus to the posterior pituitary through the internal median eminence, several of the vis...

journal_title：Neuroscience letters

authors： Alonso G,Szafarczyk A,Assenmacher I

更新日期：1986-05-23 00:00:00

abstract：:The efficacy of acetylcholine muscarinic M2 receptor-G protein coupling was investigated in Alzheimer's disease and control neocortical membranes by measuring the effects of MgCl2 and 5'-guanylylimidodiphosphate (Gpp[NH]p) on high-affinity [3H]oxotremorine-M ([3H]OXO-M) binding. MgCl2 gave similar enhancements of [3H]...

journal_title：Neuroscience letters

authors： Hérnandez-Hérnandez A,Adem A,Ravid R,Cowburn RF

更新日期：1995-02-15 00:00:00

abstract：:Sleep disturbance is common in chronic post-traumatic stress disorder (PTSD). However, prior work has demonstrated that there are inconsistencies between subjective and objective assessments of sleep disturbance in PTSD. Therefore, we investigated whether subjective or objective sleep assessment has greater clinical u...

journal_title：Neuroscience letters

authors： Tahmasian M,Jamalabadi H,Abedini M,Ghadami MR,Sepehry AA,Knight DC,Khazaie H

更新日期：2017-05-22 00:00:00

abstract：:Addition of vasopressin to hypothalamo-neurohypophysial explants in vitro increased cyclic AMP accumulation whereas exogenous oxytocin decreased cyclic AMP. An opposite response pattern was observed in the neural lobe of the pituitary where vasopressin decreased and oxytocin increased cyclic AMP accumulation. Forskoli...

journal_title：Neuroscience letters

authors： Meeker RB,Michels KM,Hayward JN

更新日期：1990-07-03 00:00:00

abstract：:Twenty-four hour patterns in somatostatin (SS)-like immunoreactivity (LI) within the suprachiasmatic nucleus (SCN) were determined by enzyme immunoassay in rats blinded by bilateral orbital enucleation or kept sighted under light-dark conditions. A remarkable circadian rhythm was found in the concentration of SS-LI in...

journal_title：Neuroscience letters

authors： Shinohara K,Isobe Y,Takeuchi J,Inouye ST

更新日期：1991-08-05 00:00:00

abstract：:Self-initiated leg movement in standing humans is preceded by a medio-lateral preparatory balance adjustment (PBA); however, such preparatory balance control is often absent in reflex-like stepping responses evoked by whole-body instability. The presence or absence of the PBA may reflect a task-dependent modulation of...

journal_title：Neuroscience letters

authors： McIlroy WE,Bent LR,Potvin JR,Brooke JD,Maki BE

更新日期：1999-06-04 00:00:00

abstract：:The topographical distribution of sciatic and femoral nerve sensory neuronal somata in the L4 dorsal root ganglion of the adult rat was mapped after retrograde tracing with one or two of the dyes Fast Blue, Fluoro-Gold, or Diamidino Yellow. The tracers were applied to the proximal transected end of either nerve alone,...

journal_title：Neuroscience letters

authors： Puigdellívol-Sánchez A,Prats-Galino A,Ruano-Gil D,Molander C

更新日期：1998-07-31 00:00:00

abstract：:A comparison of cholecystokinin (CCK) receptor binding to sections of rat, mouse and guinea pig brain has been performed using 125I-Bolton Hunter CCK and the selective peripheral CCK receptor antagonist L-365,031. In both rat and mouse, 125I-Bolton Hunter CCK binding in the region of the interpeduncular nucleus (IPN) ...

journal_title：Neuroscience letters

authors： Hill DR,Shaw TM,Woodruff GN

更新日期：1987-08-31 00:00:00

abstract：:Astrocyte cell cultures were established from human fetal brains and exposed to human recombinant tumor necrosis factor alpha (TNF alpha) and human recombinant interferon gamma (IFN gamma), and the proliferative response was assessed by bromodeoxyuridine-immunostaining technique. TNF alpha showed an inhibitory activit...

journal_title：Neuroscience letters

authors： Moretto G,Yoo A,Kim SU

更新日期：1993-03-05 00:00:00

abstract：:This study aimed to investigate the effects of ghrelin, as a neuroprotective agent, on cognitive impairment and apoptosis pathway in methamphetamine-treated male rats. Sixty adult male Wistar rats were randomly divided into six groups (n = 10): Saline/Saline (SS), Saline/Ghrelin (SG), Methamphetamine/Simultaneous Sali...

journal_title：Neuroscience letters

authors： Fallahi S,Babri S,Farajdokht F,Ghiasi R,Soltani Zangbar H,Karimi P,Mohaddes G

更新日期：2019-08-10 00:00:00

abstract：:Dopamine (DA) neurons in the ventral tegmental area and substantia nigra pars compacta were induced to fire in bursts with application of N-methyl-D-aspartate (NMDA, 20 microM) and apamin (100 nM) while recording intracellularly in the rat brain slice. L-Arginine (300 microM), a substrate for nitric oxide (NO) product...

journal_title：Neuroscience letters

authors： Cox BA,Johnson SW

更新日期：1998-10-23 00:00:00

abstract：:We have recently documented the presence of cholinergic neurons containing monoamine oxidase (MAO)-B activity in the striatum of C57BL/6 mouse. In the present study, we have mapped the topographical distributions of MAO-containing neurons in the mouse striatum. Positive neurons were located in the striatum of the enti...

journal_title：Neuroscience letters

authors： Nakamura S,Akiguchi I,Kimura J

更新日期：1995-01-16 00:00:00

abstract：:Mutations in the hairless (hr) gene of mice result in hair follicle and other epithelial defects. The hr gene is expressed at high levels in the brain where it probably participates in the survival and maintenance of some neuronal populations, but whether it also supports glial populations of the central nervous syste...

journal_title：Neuroscience letters

authors： San Jose I,García-Atares N,Pelaez B,Cabo R,Esteban I,Vega JA,Represa J

更新日期：2001-08-24 00:00:00

abstract：:This event-related functional Magnetic Resonance Imaging study examined the differential neural activities associated with a Risky-Gains task in 18 healthy individuals of high (n=9) or low (n=9) impulsiveness, according to their scores on the Barratt Impulsiveness Scale (BIS). The neural activities of people belonging...

journal_title：Neuroscience letters

authors： Lee TM,Chan CC,Han SH,Leung AW,Fox PT,Gao JH

更新日期：2008-06-20 00:00:00

abstract：:Increasing evidence shows that inflammation may contribute to the pathophysiology of depression. Apigenin, one type of natural flavone, has a number of biological actions including anti-inflammatory effects. Although it has potential antidepressant activity in a chronic mild stress model, the mechanisms of antidepress...

journal_title：Neuroscience letters

authors： Li R,Zhao D,Qu R,Fu Q,Ma S

更新日期：2015-05-06 00:00:00

abstract：:Repetitive ischemia causes more severe damage than a single insult of comparable duration. Gerbils were followed for 1 month postrepetitive ischemia and 100% mortality was demonstrated in the unprotected ischemia group by 12 days postischemia. Significant protection against mortality due to repetitive ischemia was off...

journal_title：Neuroscience letters

authors： McCrea S,Shuaib A,Wishart T,Ijaz S

更新日期：1994-03-28 00:00:00

abstract：:Loss of balance and increased fall risk is a common problem associated with aging. Changes in vestibular function occur with aging but the contribution of reduced vestibular otolith function to fall risk remains unknown. We examined a population of 151 healthy individuals (aged 21-93) for both balance (sway measures) ...

journal_title：Neuroscience letters

authors： Serrador JM,Lipsitz LA,Gopalakrishnan GS,Black FO,Wood SJ

更新日期：2009-11-06 00:00:00

abstract：:Vigabatrin (VGB, gamma-vinyl-gamma-aminobutyric acid (GABA)), an irreversible inhibitor of GABA transaminase, increases regional inhibitory effects by elevating GABA concentration and reducing glutamate synthesis. In the present study, changes in glutamate dehydrogenase (GDH) activity and its immunoreactivity in the s...

journal_title：Neuroscience letters

authors： Kang TC,An SJ,Park SK,Hwang IK,Choi SY,Kwon OS,Won MH

更新日期：2003-04-10 00:00:00

abstract：:The nucleus accumbens (NAc) shell is closely associated with reward, psychiatric disorders (depression or schizophrenia), and drug abuse. Dopamine, released from the ventral tegmental area, is involved in these physiological functions and pathophysiological changes of NAc shell. Medium spiny neurons (MSNs), which are ...

journal_title：Neuroscience letters

authors： Kohnomi S,Ebihara K,Kobayashi M

更新日期：2017-01-01 00:00:00

abstract：:Physiological and histochemical studies have clearly demonstrated the control and innervation of the sympathetic nerve on the splanchnic veins. However, the origins of postganglionic fibers remain to be determined. In this study, we used the retrograde transport of horseradish peroxidase (HRP) technique to trace the o...

journal_title：Neuroscience letters

authors： Chen HI,Kang BH,Wang JY,Tseng YL

更新日期：1994-05-23 00:00:00

abstract：:The influence of chronic arthritic pain upon the levels of mRNA encoding prodynorphin (mRNADYN) in the spinal cord of rats was evaluated by use of the RNA blot technique. Rats were rendered arthritic by inoculation of the tail-base with a suspension of Mycobacterium butyricum. Three weeks post inoculation, levels of m...

journal_title：Neuroscience letters

authors： Höllt V,Haarmann I,Millan MJ,Herz A

更新日期：1987-01-02 00:00:00

abstract：:Identified in 1993, APOE4 is the greatest genetic risk factor for Alzheimer's disease (AD), increasing risk up to 15-fold compared to the common variant APOE3. Since the mid 1990's, transgenic (Tg) mice have been developed to model AD pathology and progression, primarily via expression of the familial AD (FAD) mutatio...

journal_title：Neuroscience letters

authors： Balu D,Karstens AJ,Loukenas E,Maldonado Weng J,York JM,Valencia-Olvera AC,LaDu MJ

更新日期：2019-08-10 00:00:00

abstract：:Iontophoretic application of the 5-HT2 receptor agonist alpha-methyl-5-HT excited 41 neurones in the rostral ventrolateral medulla, including a population of barosensitive cells. At high ejecting currents (greater than 2-3 x threshold) the excitation was replaced by an inhibition. The excitatory responses evoked by lo...

journal_title：Neuroscience letters

authors： Wang WH,Lovick TA

更新日期：1992-07-06 00:00:00

abstract：:Several studies have indicated that higher levels of childhood aerobic fitness is associated with superior cognitive function, and this association is disproportionately observed in tasks requiring greater top-down control. We designed the current study to clarify the relationship between childhood fitness and top-dow...

journal_title：Neuroscience letters

authors： Kamijo K,Takeda Y,Takai Y,Haramura M

更新日期：2016-10-06 00:00:00

abstract：:Numerous studies have provided evidence for a genetic association of the Apolipoprotein E (ApoE) epsilon4 allele and late onset familial and sporadic Alzheimer's disease (AD). Clinical observations show that a proportion of schizophrenic patients may suffer from severe cognitive impairment. That could reflect a partic...

journal_title：Neuroscience letters

authors： Sorbi S,Nacmias B,Tedde A,Latorraca S,Forleo P,Guarnieri BM,Petruzzi C,Daneluzzo E,Ortenzi L,Piacentini S,Amaducci L

更新日期：1998-03-13 00:00:00