Combined behavioral studies and in vivo imaging of inflammatory response and expression of mGlu5 receptors in schnurri-2 knockout mice.

abstract：:Pituitary adenylate cyclase-activating polypeptide-like immunoreactive (PACAP-LI) neuronal elements in the rat hypothalamus including the median eminence (ME) were investigated by light and electron microscopic immunocytochemistry. PACAP-LI neuronal perikarya with well-developed cell organelles and dense granules were...

journal_title：Neuroscience letters

authors： Tamada Y,Tanaka M,Ichitani Y,Okamura H,Yanaihara N,Ibata Y

更新日期：1994-10-24 00:00:00

abstract：:The binding of the lectin soybean agglutinin (SBA) to the olfactory system of both the rat and mouse was investigated histochemically. SBA bound to fibers in the accessory olfactory nerve and to glomeruli in the accessory olfactory bulb. In addition, SBA binding sites were present in some, but not all, glomeruli in th...

journal_title：Neuroscience letters

authors： Key B,Giorgi PP

更新日期：1986-08-29 00:00:00

abstract：:The pituitary-adrenal responsiveness to a mild stressor was assessed in rats that were deprived of paradoxical sleep (PS) and in controls that were not deprived. Animals were either individually- or group-deprived for 96 h and hormone levels were assessed at 0, 5, 20 or 60 min after a saline injection+novelty and comp...

journal_title：Neuroscience letters

authors： Suchecki D,Tiba PA,Tufik S

更新日期：2002-03-01 00:00:00

abstract：:The inferior alveolar nerves (IAN) of young male Wistar rats (b.wt. greater than or equal to 200 g) were transected unilaterally, slightly proximal to the mandibular foramen under anesthesia with chloral hydrate (0.4 g/kg, i.p.). After various postoperative periods of time, the animals received horseradish peroxidase ...

journal_title：Neuroscience letters

authors： Takemura M,Sugimoto T,Wakisaka S,Akai M

更新日期：1990-01-01 00:00:00

abstract：:A prevailing hypothesis is that neurogenesis is reduced in depression and that the common mechanism for antidepressant treatments is to increase it in adult hippocampus. Reduced neurogenesis has been shown in healthy rats exposed to stress, but it has not yet been demonstrated in depressed patients. Emerging studies n...

journal_title：Neuroscience letters

authors： Petersén A,Wörtwein G,Gruber SH,El-Khoury A,Mathé AA

更新日期：2009-02-20 00:00:00

abstract：:1,3-di(2-[5-3H]tolyl)Guanidine ([3H]DTG) was found to bind to a single saturable population of binding sites in human cerebral cortex and NCB20 cells, a second low-affinity site was apparent in guinea pig brain. Displacement studies were performed to determine the pharmacology of the [3H]DTG binding site in these 3 me...

journal_title：Neuroscience letters

authors： Knight AR,Gillard J,Wong EH,Middlemiss DN

更新日期：1991-10-14 00:00:00

abstract：:Whole-cell recordings were obtained from respiratory neurons by applying patch-clamp techniques in the en bloc medulla of in vitro neonatal rat brainstem-spinal cord preparations. Stable voltage-clamp recordings of excitatory or inhibitory synaptic drive currents and current-clamp recordings of spike discharge of insp...

journal_title：Neuroscience letters

authors： Smith JC,Ballanyi K,Richter DW

更新日期：1992-01-06 00:00:00

abstract：:The pharmacokinetics of 2-amino-7-phosphonoheptanoate (AP7) in rat plasma and appearance in cerebrospinal fluid (CSF) are reported. Using high-performance liquid chromatography (HPLC) with fluorescence detection, concentrations of AP7 can be detected as low as 1.0 microM. Peak CSF concentrations (12-15 microM) for bot...

journal_title：Neuroscience letters

authors： Compton RP,Hood WF,Monahan JB

更新日期：1988-02-03 00:00:00

abstract：:After systemic administration of the dopamine agonist apomorphine (APO) in common toads Bufo bufo spinosus, the excitatory receptive fields of retinal R2 and R3 ganglion cells doubled their size and the response activities of these neurons to moving visual stimuli were generally increased. Comparable investigations of...

journal_title：Neuroscience letters

authors： Glagow M,Ewert JP

更新日期：1994-05-23 00:00:00

abstract：:The objective of this study was to determine if yohimbine, a central norepinephrine enhancing drug, increases cortico-motoneuronal excitability in intact humans. Transcranial magnetic stimulation was used to assess excitability of the motor system reflected in the parameters motor threshold, recruitment curve, intraco...

journal_title：Neuroscience letters

authors： Plewnia C,Bartels M,Cohen L,Gerloff C

更新日期：2001-07-06 00:00:00

abstract：:Age dependent EEG signatures were detected in the EEG of 71 neonates of 28-100 weeks of conceptional age (CA). Using the new method presented, neonates were automatically classified in three age groups (28-35 weeks CA), (36-40 weeks CA) and (41-100 weeks CA). Analysis was performed employing relative distance function...

journal_title：Neuroscience letters

authors： Holthausen K,Breidbach O,Scheidt B,Frenzel J

更新日期：1999-06-25 00:00:00

abstract：:Viral infections are frequently found in opioid addicts, subjecting them to immune challenge. However, the effects of immune challenge on opioid withdrawal are not fully understood. In the present study, mice were intraperitoneally injected with 2mg/kg polyinosinic-polycytidylic acid (Poly I:C, a viral mimetic) for 3 ...

journal_title：Neuroscience letters

authors： Chen L,Zhai H,Lu L,Chen S,Ning Y,Wang W

更新日期：2011-01-10 00:00:00

abstract：:In 8 subjects the spontaneous termination of sleep was determined after repetitive exposure to either bright or dim light, between 6.00 and 9.00 h, on 3 days preceding sleep assessment. Sleep duration was significantly shorter following bright light than following dim light. During sleep the time course of EEG energy ...

journal_title：Neuroscience letters

authors： Dijk DJ,Visscher CA,Bloem GM,Beersma DG,Daan S

更新日期：1987-01-14 00:00:00

abstract：:Systemic administration of nitroglycerin (NTG) consistently provokes spontaneous-like migraine attacks in migraine sufferers, and in rat it induces hyperalgesia and allodynia. In the present study we modeled migraine headache by intraperitoneal (i.p.) injection of a single dose of NTG, which produced widespread therma...

journal_title：Neuroscience letters

authors： Farajdokht F,Babri S,Karimi P,Mohaddes G

更新日期：2016-09-06 00:00:00

abstract：:The calcitonin-gene receptor peptide (alphaCGRP) receptor is present in high levels in the caudal striatum of the rat. Previous behavioural experiments have highlighted a possible correlation between alphaCGRP-mediated effects and the dopaminergic system. In this study, we examined the effect of alphaCGRP on K(+)-evok...

journal_title：Neuroscience letters

authors： Maneuf YP,McKnight AT

更新日期：2001-09-14 00:00:00

abstract：:Constant bright light (LL) suppresses 24-h melatonin and many other behavioral and physiological rhythms in pigeons. LL also strongly suppresses sleep. Daily melatonin infusions in LL restore sleep to normal nocturnal levels of a light-dark cycle and continuous infusions sustain it for at least 10 days. Restoration of...

journal_title：Neuroscience letters

authors： Phillips NH,Berger RJ

更新日期：1992-10-12 00:00:00

abstract：:CSF-A beta 42 may be a marker of Alzheimer's disease (AD). A decreased level of CSF-A beta 42 is consistently found in AD and has been suggested to be related to the deposition of amyloid plaques in the brain. However, low CSF-A beta 42 levels have also been found in disorders devoid of plaques, for instance Creutzfel...

journal_title：Neuroscience letters

authors： Sjögren M,Gisslén M,Vanmechelen E,Blennow K

更新日期：2001-11-13 00:00:00

abstract：:Substantial evidence supports the hypothesis that oxygen free radicals are involved in various neurodegenerative disorders. To assess the presence of oxidative stress in Alzheimer's disease (AD) we examined the activity of the enzyme copper-zinc superoxide dismutase (CuZnSOD) in red blood cells, the levels of the mito...

journal_title：Neuroscience letters

authors： De Leo ME,Borrello S,Passantino M,Palazzotti B,Mordente A,Daniele A,Filippini V,Galeotti T,Masullo C

更新日期：1998-07-10 00:00:00

abstract：:Neuropeptide S (NPS) is a recently discovered peptide shown to be involved in regulating arousal and anxiety. NPS receptor (NPSR) mRNA is expressed significantly in the major input and output regions of hippocampal formation, which are critical in the modulation of learning and memory. However, the role of NPS/NPSR sy...

journal_title：Neuroscience letters

authors： Han RW,Yin XQ,Chang M,Peng YL,Li W,Wang R

更新日期：2009-05-08 00:00:00

abstract：:Noradrenergic fibers from the locus ceruleus were identified in close proximity to brain microvessels, and adrenoceptors exist in isolated brain capillaries. Yet, proof of innervation of brain microvessels by locus ceruleus remains elusive. We now demonstrate increased density of beta-adrenoceptors by pindolol binding...

journal_title：Neuroscience letters

authors： Kalaria RN,Stockmeier CA,Harik SI

更新日期：1989-02-13 00:00:00

abstract：:Painful and non-painful phantom phenomena occur frequently after amputations but are rarely investigated in the perioperative stage. The goal of the present study was the assessment of phantom phenomena, pain and changes in primary somatosensory cortex prior to and after upper limb amputation. Two patients who suffere...

journal_title：Neuroscience letters

authors： Grüsser SM,Winter C,Schaefer M,Fritzsche K,Benhidjeb T,Tunn P,Schlag PM,Flor H

更新日期：2001-04-13 00:00:00

abstract：:The study of neural arousal mechanisms has been greatly aided by the discovery of the orexin peptides (orexin A and orexin B), the subsequent identification of the neurons that synthesize these peptides, their projections in the brain, and the distribution of orexin receptors in the central nervous system. Orexin neur...

journal_title：Neuroscience letters

authors： Brown TM,Coogan AN,Cutler DJ,Hughes AT,Piggins HD

更新日期：2008-12-31 00:00:00

abstract：:In vitro pituitary adenylate cyclase activating polypeptide (PACAP) induces the expression of brain-derived neurotrophic factor (BDNF) via its specific receptor PAC1. Since BDNF has been implicated in learning paradigms and mice lacking functional PAC1 have deficits in hippocampus-dependent associative learning, we in...

journal_title：Neuroscience letters

authors： Zink M,Otto C,Zörner B,Zacher C,Schütz G,Henn FA,Gass P

更新日期：2004-04-22 00:00:00

abstract：:A comparative study was made of the enzyme choline acetyltransferase (ChAT) from normal and Alzheimer (senile dementia of the Alzheimer type) brain. The number of molecular weight and charge forms of the enzyme were determined in the caudate region of both brains. Efficient purification of active ChAT was achieved usi...

journal_title：Neuroscience letters

authors： Bruce G

更新日期：1985-08-30 00:00:00

abstract：:Although a linear correlation between oscillatory activities in the right and left motor cortices during movements has been shown in monkeys, there has been a debate whether scalp-recorded EEG coherence in human reflects a similar association. By applying partial coherence analysis, we demonstrated that interhemispher...

journal_title：Neuroscience letters

authors： Mima T,Matsuoka T,Hallett M

更新日期：2000-06-23 00:00:00

abstract：:A pronounced decrease in dopamine content in both the striatum and the mesolimbic area was observed up to 120 days of age after treatment with 6-hydroxydopamine (100 micrograms, intracisternally) following desipramine pretreatment (20 mg/kg, i.p.) at the 5th postnatal day. In the 6-hydroxydopamine-treated rats, Met-en...

journal_title：Neuroscience letters

authors： Kurumaji A,Takashima M,Watanabe S,Takahashi K

更新日期：1988-04-22 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) immunoreactive afferent nerves were seen intrarenally by prenatal day 16. They grow rapidly and CGRP positive nerves are observed at birth associated with the arterial and venous vascular tree, forming a rich plexus in the pelvic region and in the connective tissue located near t...

journal_title：Neuroscience letters

authors： Barajas L,Liu L,Nishiyama C

更新日期：1991-12-09 00:00:00

abstract：:We examined the effect of intraventricular injection of nerve growth factor (NGF) on the choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) mRNA expression in the septa of neonatal rats. Rat pups were injected with 2.5 S NGF or cytochrome-c (control) on postnatal days (PN) 4 and 18, and s...

journal_title：Neuroscience letters

authors： Tian X,Sun X,Suszkiw JB

更新日期：1996-05-10 00:00:00

abstract：:We studied whether eugenol provides neuroprotection against delayed neuronal death in the hippocampal CA1 region following a 5 min occlusion of the common carotid arteries bilaterally under either free-regulating temperature (TF) or maintained temperature (TM, 37 degrees C) conditions in gerbils. Right after occlusion...

journal_title：Neuroscience letters

authors： Won MH,Lee JC,Kim YH,Song DK,Suh HW,Oh YS,Kim JH,Shin TK,Lee YJ,Wie MB

更新日期：1998-09-25 00:00:00

abstract：:Depressive disorders represent a significant health concern as they are associated with high social and physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective treatment for patients with drug-resistant severe depressive disorders. However, the underlying biological m...

journal_title：Neuroscience letters

authors： Fryland T,Elfving B,Christensen JH,Mors O,Wegener G,Børglum AD

更新日期：2012-05-10 00:00:00