Abstract：
:Pituitary adenylate cyclase-activating polypeptide-like immunoreactive (PACAP-LI) neuronal elements in the rat hypothalamus including the median eminence (ME) were investigated by light and electron microscopic immunocytochemistry. PACAP-LI neuronal perikarya with well-developed cell organelles and dense granules were distributed mainly in the magnocellualr portion of the paraventricular nucleus and throughout the entire supraoptic nucleus. In the ME, numerous PACAP-LI neuronal processes were found in the internal layer (IL), and immunoreactive terminals containing dense granules, vesicles and mitochondria were detected around portal capillaries which penetrated into the IL from the external layer. Thereafter, PACAP is released into the portal capillaries in the IL, transported to the anterior pituitary and plays a role in the stimulation of adenylate cyclase of anterior pituitary cells.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Tamada Y,Tanaka M,Ichitani Y,Okamura H,Yanaihara N,Ibata Ydoi
10.1016/0304-3940(94)90498-7subject
Has Abstractpub_date
1994-10-24 00:00:00pages
105-8issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(94)90498-7journal_volume
180pub_type
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