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Autophagy-related gene16L2, a potential serum biomarker of multiple sclerosis evaluated by bead-based proteomic technology.

Abstract：

:Multiple sclerosis (MS) is an autoimmune disease characterized by neuroinflammation and demyelination that are mediated by T cells. The prolonged survival of autoreactive T cells acts as a primary event to trigger an inflammatory cascade that mediates myelin loss and clinical relapse in MS. Recently, T cell survival has been shown to be modulated by the autophagy-related gene (Atg). In the present study, we performed bead fractionation/matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry analyses using serum from 54 MS patients and 55 healthy controls. Eleven peptides were significantly different between the two groups with one being identified as a fragment of Atg16L2. Then the decreased levels of Atg16L2 peptides in MS patients were validated by immunoblotting and real-time PCR. As the Atg12-Atg5·Atg16 multimeric complex plays an essential role in autophagy, our results suggest that Atg16L2 may play an important role in autophagy of T cells and serve as a potential biomarker to predict clinical relapse of MS.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Yin L,Liu J,Dong H,Xu E,Qiao Y,Wang L,Zhang L,Jia J,Li L,Geng X

doi

10.1016/j.neulet.2013.12.070

subject

Has Abstract

pub_date

2014-03-06 00:00:00

pages

34-8

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(14)00007-X

journal_volume

562

pub_type

杂志文章

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