Diffusive oxidative stress following acute spinal cord injury in guinea pigs and its inhibition by polyethylene glycol.

Abstract:

:Spinal cord injury (SCI) results in rapid and significant oxidative stress. We have previously demonstrated that polyethylene glycol (PEG) repairs neuronal membrane and inhibits lipid peroxidation in an in vitro model of SCI. In this study we tested the effects of PEG on oxidative stress in guinea pigs after SCI. Oxidative stress was assessed by lipid peroxidation, protein carbonyl and glutathione content. A compression injury of spinal cord at T10-11 induced a rapid and diffusive oxidative stress. Administration of PEG immediately after injury resulted in a marked decrease in oxidative stress both at the injury site and in its adjacent segments. These results, along with our previous findings, suggest that an early application of PEG can effectively suppress oxidative stress after SCI in vivo.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Luo J,Shi R

doi

10.1016/j.neulet.2004.02.027

keywords:

subject

Has Abstract

pub_date

2004-04-15 00:00:00

pages

167-70

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304394004002113

journal_volume

359

pub_type

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