The effect of bilateral low-frequency rTMS over dorsolateral prefrontal cortex on serum brain-derived neurotropic factor and serotonin in patients with generalized anxiety disorder.

Abstract:

:To investigate the effect of bilateral low-frequency repetitive transcranial magnetic stimulation (rTMS) over dorsolateral prefrontal cortex on serum brain-derived neurotropic factor (BDNF) and serotonin (5-HT) in patients with generalized anxiety disorders (GAD). As compared with before treatment, the HARS score in patients markedly decreased after treatment, and the levels of serum BDNF and 5-HT were significantly higher. Pearson correlation analysis revealed that the increase in the level of serum 5-HT was positively associated with the increase of the level of serum BDNF, and the change of anxiety score was negatively associated with the change of the level of serum BDNF and 5-HT. The results suggested that alleviation of GAD by bilateral low-frequency rTMS may be involved in the increase of the level of BDNF and the release of 5-HT in the brain.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Lu R,Zhang C,Liu Y,Wang L,Chen X,Zhou X

doi

10.1016/j.neulet.2018.07.008

subject

Has Abstract

pub_date

2018-09-25 00:00:00

pages

67-71

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(18)30477-4

journal_volume

684

pub_type

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