Abstract:
:To investigate the effect of bilateral low-frequency repetitive transcranial magnetic stimulation (rTMS) over dorsolateral prefrontal cortex on serum brain-derived neurotropic factor (BDNF) and serotonin (5-HT) in patients with generalized anxiety disorders (GAD). As compared with before treatment, the HARS score in patients markedly decreased after treatment, and the levels of serum BDNF and 5-HT were significantly higher. Pearson correlation analysis revealed that the increase in the level of serum 5-HT was positively associated with the increase of the level of serum BDNF, and the change of anxiety score was negatively associated with the change of the level of serum BDNF and 5-HT. The results suggested that alleviation of GAD by bilateral low-frequency rTMS may be involved in the increase of the level of BDNF and the release of 5-HT in the brain.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Lu R,Zhang C,Liu Y,Wang L,Chen X,Zhou Xdoi
10.1016/j.neulet.2018.07.008subject
Has Abstractpub_date
2018-09-25 00:00:00pages
67-71eissn
0304-3940issn
1872-7972pii
S0304-3940(18)30477-4journal_volume
684pub_type
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