Abstract:
:Nanomolar concentrations of vasoactive intestinal peptide (VIP), picomolar concentrations of stearyl-norleucine17-VIP (SNV) and femtomolar concentrations of NAPVSIPQ (NAP), an 8-amino-acid peptide derived from the VIP-responsive activity-dependent neuroprotective protein, provide broad neuroprotection. In rat cerebral cortical cultures, 10(-16)-10(-7) M NAP increased intracellular cyclic guanosine monophosphate (cGMP) (2.5-4-fold) and 10(-10) M NAP increased extracellular nitric oxide (NO) by 60%. In the same culture system, VIP and SNV (at micromolar concentrations) increased extracellular NO by 45-55%. The NAP dose required for cGMP increases correlated with the dose providing neuroprotection. However, the concentrations of NAP, SNV and VIP affecting NO production did not match the neuro-protective doses. Thus, NO may mediate part of the cell-cell interaction and natural maintenance activity of VIP/SNV/NAP, while cGMP may mediate neuroprotection.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ashur-Fabian O,Giladi E,Furman S,Steingart RA,Wollman Y,Fridkin M,Brenneman DE,Gozes Idoi
10.1016/s0304-3940(01)01954-1keywords:
subject
Has Abstractpub_date
2001-07-20 00:00:00pages
167-70issue
3eissn
0304-3940issn
1872-7972pii
S0304394001019541journal_volume
307pub_type
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