Abstract：
:The present study was undertaken to determine whether the postsynaptic inhibition of motoneurons that occurs following the pontine microinjection of carbachol in the decerebrate cat is due to the activity of Renshaw cells. Thirty-two out of 37 Renshaw cells (86%) were spontaneously active prior to the administration of carbachol, whereas only 2 out of 13 Renshaw cells (15%) discharged during carbachol-induced motor inhibition. In addition, discrete inhibitory synaptic potentials were observed in 33% of the Renshaw cells from which intracellular recordings were obtained after carbachol administration, indicating that these cells were actively inhibited. The finding that a population of Renshaw cells, which inhibit motoneurons, were themselves inhibited during a period of profound motoneuron inhibition was quite unexpected. These results support the conclusion that Renshaw cells are not the inhibitory interneurons that are responsible for the powerful inhibition of motoneurons that occurs following the pontine microinjection of carbachol.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Morales FR,Engelhardt JK,Pereda AE,Yamuy J,Chase MHdoi
10.1016/0304-3940(88)90498-3subject
Has Abstractpub_date
1988-04-12 00:00:00pages
289-95issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(88)90498-3journal_volume
86pub_type
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