Two distinctive antinociceptive systems in rats with pathological pain.

abstract：:Parkinson's disease (PD) is characterized by bradykinesia, resting tremor, rigidity and postural instability as well as early symptoms. Previous studies that evaluated the association between H1/H2 MAPT haplotype and PD were mostly conducted in European populations in which the H1 haplotype was a reported risk factor ...

journal_title：Neuroscience letters

authors： Miranda-Morales EG,Sandoval-Carrillo A,Castellanos-Juárez FX,Méndez-Hernández EM,La Llave-León O,Quiñones-Canales G,Ruano-Calderón LA,Arias-Carrión O,Salas-Pacheco JM

更新日期：2019-01-18 00:00:00

abstract：:The content of synaptophysin, a vesicular integral membrane protein of neurons and endocrine cells, and that of vasopressin was measured in neurohypophyses of rats during chronic osmotic stimulation. The animals received 2% NaCl in their drinking water for up to 4 days. Synaptophysin content of neurohypophyses was det...

journal_title：Neuroscience letters

authors： Ehrhart-Bornstein M,Thorn NA,Treiman M

更新日期：1990-10-30 00:00:00

abstract：:The activity of the septo-hippocampal cholinergic pathway was investigated by measuring changes in the extracellular acetylcholine (ACh) levels in the hippocampus, by means of microdialysis, during the operant conditioned reflex and the repeated footshock stimulus. Microdialysis samplings were conducted in a Skinner b...

journal_title：Neuroscience letters

authors： Dong Y,Mao J,Shangguan D,Zhao R,Liu G

更新日期：2004-10-14 00:00:00

abstract：:In order to study the rapidity of interaction between tetraethylammonium (TEA) and the delayed K+ channel of the mammalian brain neuron, TEA was applied to isolated rat hippocampal pyramidal neurons in a time-controlled sequence with a voltage step using a concentration clamp technique. TEA at a concentration of 30 mM...

journal_title：Neuroscience letters

authors： Oyama Y,Harata N,Akaike N

更新日期：1991-10-14 00:00:00

abstract：:We investigated the possibility of obtaining an anteroposterior body response to galvanic vestibular stimulation (GVS) by applying an equivalent stimulus to both sides of the vestibular apparatus. An original 'double fronto-mastoidal' stimulation was used on eight subjects standing with their head facing forwards. Bot...

journal_title：Neuroscience letters

authors： Séverac Cauquil A,Gervet MF,Ouaknine M

更新日期：1998-03-27 00:00:00

abstract：:It is generally assumed that the majority of substance P (SP)-containing afferents are also immunoreactive for calcitonin gene-related peptide (CGRP). In order to determine whether this is also the case in articular afferents where the contents of these peptides are low, we carried out a double labeling study using Fa...

journal_title：Neuroscience letters

authors： Tamura R,Hanesch U,Schmidt RF,Kumazawa T,Mizumura K

更新日期：1998-09-18 00:00:00

abstract：:Recent imaging studies have reported the projection of semicircular canal signals onto wide regions of the cerebral cortex but little is known about otolith projections onto the cerebral cortex. We used functional magnetic resonance imaging (fMRI) to investigate the activation of the cortex by loud clicks that selecti...

journal_title：Neuroscience letters

authors： Miyamoto T,Fukushima K,Takada T,de Waele C,Vidal PP

更新日期：2007-08-09 00:00:00

abstract：:We used quantitative in situ hybridization to study changes in the expression of c-fos following hypoxic-ischemia (H-I) in the neonatal rat brain. 7-day-old rat pups were subjected to a unilateral ligation of the common carotid artery followed by a 2 h 15 min hypoxic period (7.7% O2 in N2). This resulted in the expect...

journal_title：Neuroscience letters

authors： Adén U,Bona E,Hagberg H,Fredholm BB

更新日期：1994-10-24 00:00:00

abstract：:Pharmacologic blockade of excitatory amino acid receptors, especially the N-methyl-D-aspartate-preferring subclass of glutamate receptors, has been shown to reduce neuronal damage in models of global cerebral ischemia followed by reperfusion. The pharmacologic blockade at the NMDA receptor attenuates infarct size foll...

journal_title：Neuroscience letters

authors： Roman R,Bartkowski H,Simon R

更新日期：1989-09-25 00:00:00

abstract：:Oxidative damage induced-mitochondrial dysfunction and apoptosis has been widely studied in spinal cord injury (SCI). Lycopene, a polyunsaturated hydrocarbon, has the highest antioxidant capacity compared to the other carotenoids. However, the role of lycopene in SCI is unknown. In the present study, we evaluated the ...

journal_title：Neuroscience letters

authors： Hu W,Wang H,Liu Z,Liu Y,Wang R,Luo X,Huang Y

更新日期：2017-03-06 00:00:00

abstract：:To better understand the pathophysiological role of Src protein, a non-receptor protein tyrosine kinase of 60kDa, in the ischemic brain, we investigated the time course and regional distribution of active Src expression by using a specific antibody against Tyr416 phosphorylated Src (phospho-Src) in the rat hippocampus...

journal_title：Neuroscience letters

authors： Choi JS,Kim HY,Chung JW,Chun MH,Kim SY,Yoon SH,Lee MY

更新日期：2005-05-20 00:00:00

abstract：:Dopamine (DA) neurons in the ventral tegmental area and substantia nigra pars compacta were induced to fire in bursts with application of N-methyl-D-aspartate (NMDA, 20 microM) and apamin (100 nM) while recording intracellularly in the rat brain slice. L-Arginine (300 microM), a substrate for nitric oxide (NO) product...

journal_title：Neuroscience letters

authors： Cox BA,Johnson SW

更新日期：1998-10-23 00:00:00

abstract：:Treatment with dopamine and other dopamine D2 receptor agonists has been shown to induce cell death through activation of caspase-3 pathway. However, initial step that leads to the activation of caspase-3 in D2 receptor-mediated apoptotic pathway remains unclear. Recently, it was shown that a spliced variant of Galpha...

journal_title：Neuroscience letters

authors： López-Aranda MF,Navarro-Lobato I,López-Téllez JF,Blanco E,Masmudi-Martín M,Khan ZU

更新日期：2008-07-04 00:00:00

abstract：:The number of neurons in the primary motor cortex (MI) and the primary somatosensory cortex (SI) were estimated in the same locations of brains from sporadic amyotrophic lateral sclerosis (ALS) cases and controls. The number of MI and SI neurons and Betz cells were significantly decreased in the ALS cases as compared ...

journal_title：Neuroscience letters

authors： Mochizuki Y,Mizutani T,Shimizu T,Kawata A

更新日期：2011-09-26 00:00:00

abstract：:Neuropeptides, synthesized in dorsal root ganglia (DRG), are implicated in nociception and neurogenic inflammation. Alterations in DRG neuropeptide levels have been described in polyarthritic rats, but these models are associated with widespread systemic disease. Using mild adjuvant-mediated monoarthritis of the left ...

journal_title：Neuroscience letters

authors： Smith GD,Harmar AJ,McQueen DS,Seckl JR

更新日期：1992-03-30 00:00:00

abstract：:DSP-4[N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride] is a neurotoxin that depletes norepinephrine. The catecholaminergic system has been implicated in the regulation of blood glucose level. In the present study, the effect of DSP-4 administered intracerebroventricularly (i.c.v.) or intrathecally (i.t.) on...

journal_title：Neuroscience letters

authors： Park SH,Kim SS,Lee JR,Sharma N,Suh HW

更新日期：2016-05-04 00:00:00

abstract：:Doxorubicin, a fluorescent retrograde neurotoxin, killed neurons in the ventral tegmentum and thalamus that were afferent to the injection site in the caudate-putamen. The neurotoxic effects in the ventral tegmentum and thalamus were prevented by a large coronal knife cut caudal to the injection site in the striatum, ...

journal_title：Neuroscience letters

authors： van der Kooy D,Zito KA,Roberts DC

更新日期：1985-01-21 00:00:00

abstract：:Adult rat chromaffin cells proliferate in vivo in response to neurally derived signals. Their proliferation in vitro is stimulated either by peptide growth factors or by activators of adenylate cyclase or protein kinase C that mimic the effects of neurotransmitters in adrenal medullary nerve endings. Differing suscept...

journal_title：Neuroscience letters

authors： Tischler AS,Riseberg JC,Cherington V

更新日期：1994-02-28 00:00:00

abstract：:Experiments involving the acute administration of a central cholinergic substance (L-acetylcarnitine) were performed on 6 healthy subjects to obtain additional evidence that the electrophysiological method developed by Bussel and Pierrot-Deseilligny in 1977 does actually assess recurrent inhibition in man. In all the ...

journal_title：Neuroscience letters

authors： Mazzocchio R,Rossi A

更新日期：1989-11-20 00:00:00

abstract：:The density of hippocampal adenosine A1 receptors was measured in autopsy samples of six patients with dementia with either Alzheimer (three) or sclerosis type pathology (three) in hippocampus and six control patients. Kinetic parameters (Bmax and KD) were determined by means of quantitative autoradiography using [3H]...

journal_title：Neuroscience letters

authors： Deckert J,Abel F,Künig G,Hartmann J,Senitz D,Maier H,Ransmayr G,Riederer P

更新日期：1998-03-06 00:00:00

abstract：:Basal and interferon (IFN)-induced levels of (2'-5') oligoadenylate synthetase activity were measured in astrocyte cultures from the mouse cerebral cortex, in neurone-enriched and mixed cerebellar cultures, and in two continuous neural cell lines by a radioimmunoassay procedure. All untreated cultures contained measur...

journal_title：Neuroscience letters

authors： Hirsch MR,Cailla H,Wietzerbin J,Goridis C

更新日期：1986-04-11 00:00:00

abstract：:Beta,beta'-Iminodipropionitrile (IDPN) is known to produce a massive accumulation of neurofilaments in the proximal portion of axons of spinal anterior horn cells. The spinal cords of 20 Wistar rats treated with IDPN were examined immunohistochemically with a monoclonal antibody against heparan sulfate (HepSS-1). Virt...

journal_title：Neuroscience letters

authors： Wada M,Kato T,Kurita K,Shikama Y,Toyoshima I,Sasaki H

更新日期：1995-12-29 00:00:00

abstract：:Rim is a multi-domain, active zone protein that regulates exocytosis and is implicated in vesicle priming and presynaptic plasticity. We recently demonstrated that synaptic defects associated with loss of Caenorhabditis elegans Rim (termed UNC-10) are accompanied by a reduction in docked vesicles adjacent to the presy...

journal_title：Neuroscience letters

authors： Gracheva EO,Hadwiger G,Nonet ML,Richmond JE

更新日期：2008-10-24 00:00:00

abstract：:Spinocerebellar ataxias (SCAs) are a group of clinically and genetically heterogeneous neurological diseases. The expansion of unstable microsatellite repeats has been identified as the underlying pathogenic cause of 10 subtypes of autosomal dominant SCAs. The aetiology of sporadic SCA is unknown. The aim of this stud...

journal_title：Neuroscience letters

authors： Majounie E,Wardle M,Muzaimi M,Cross WC,Robertson NP,Williams NM,Morris HR

更新日期：2007-12-11 00:00:00

abstract：:A comparison has been made of the effects of carbon monoxide (CO) or nitrogen (N2) exposure on synaptic transmission in the hippocampal slice. CA1 field potentials, evoked by Schaffer collateral stimulation, were unaffected by superfusion of slices with artificial cerebral spinal fluid (ACSF) equilibrated with either ...

journal_title：Neuroscience letters

authors： Doolette DJ,Kerr DI

更新日期：1992-04-13 00:00:00

abstract：:Exercise increases the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus and beneficially contributes to cognitive function and is accompanied by epigenetic changes. Specifically, the activity levels of histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate histone acetylat...

journal_title：Neuroscience letters

authors： Li X,Inoue T,Hayashi M,Maejima H

更新日期：2019-07-27 00:00:00

abstract：:In astrocytes, ion currents are predominantly carried by K(+) ions, and their potassium channel expression changes during development. Here, we studied ion current generated by voltage-ramp protocols in cultured astrocytes from the corpus callosum of newborn (P0) and 28-day-old (P28) rats. Inward currents measured at ...

journal_title：Neuroscience letters

authors： Montiel-Herrera M,García-Colunga J

更新日期：2010-11-26 00:00:00

abstract：:We have examined the morphology and distribution of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-diaphorase) cells in the retina of the guinea pig. Two morphologically distinct classes of labelled cells were detected, one with larger, darkly labelled somata commonly located in the inner nuclear layer ...

journal_title：Neuroscience letters

authors： Cobcroft M,Vaccaro T,Mitrofanis J

更新日期：1989-08-14 00:00:00

abstract：:A valinomycin-based membrane phase for microelectrodes with relatively low electrical membrane resistances is described. Microelectrodes with tip diameters of about 1 micron exhibit resistances of about 10(10) omega. Extremely high K+ selectivities are obtained, e.g. a rejection of Na+ by a factor of 5000 and of acety...

journal_title：Neuroscience letters

authors： Ammann D,Chao PS,Simon W

更新日期：1987-02-24 00:00:00

abstract：:While alpha- and beta-synuclein largely overlap in their expression in the vertebrate brain, only alpha-synuclein accumulates in the fibrillar aggregates typical of Parkinson's disease. It is thus critical to have immunological reagents that distinguish between these two protein isoforms. The monoclonal antibody Syn-1...

journal_title：Neuroscience letters

authors： Perrin RJ,Payton JE,Barnett DH,Wraight CL,Woods WS,Ye L,George JM

更新日期：2003-10-02 00:00:00