Excitatory amino acids as transmitter candidates of vibrissae afferent fibres to the rat trigeminal nucleus caudalis.

Abstract:

:Responses of single neurones to vibrissal stimulation and to the iontophoretically applied putative neurotransmitters, L-glutamate and L-aspartate, were recorded in the trigeminal nucleus caudalis of the rat. Vibrissal responses were unaffected by the specific N-methyl-D-aspartate receptor antagonist, D-alpha-aminoadipate, but were antagonized by the broad-spectrum amino acid antagonist cis-2,3-piperidine dicarboxylate. These findings suggest that the neurotransmitter of vibrissae afferent fibres may be an endogenous excitatory amino acid acting at a receptor other than the N-methyl-D-aspartate receptor.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Salt TE,Hill RG

doi

10.1016/0304-3940(81)90085-9

subject

Has Abstract

pub_date

1981-03-10 00:00:00

pages

183-7

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(81)90085-9

journal_volume

22

pub_type

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