Abstract:
:Some granule neurons naturally undergo apoptosis in the external granular layer (EGL) of the postnatally developing rat cerebellum. We analyzed the developmental stage-specificity of this apoptosis using double staining by in situ nick end labeling and immunohistochemistry against three proteins expressed at specific stages of granule neuron development. The amount of apoptosis of EGL neurons peaked on postnatal day 9. In the 9-day-old rat cerebellum, 54.0% of apoptotic EGL neurons expressed proliferating cell nuclear antigen. On the other hand, 22.2 and 15.4% of apoptotic EGL neurons existed in the postmitotic and premigratory zone defined by expression of TAG-1 and 440 kDa ankyrinB, respectively. Thus, proliferative granule neurons undergo apoptosis more frequently than postmitotic granule neurons in EGL of the developing cerebellum. This suggests that there are developmental stage-specific mechanisms of apoptosis of cerebellar granule neurons.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Tanaka M,Marunouchi Tdoi
10.1016/s0304-3940(98)00032-9subject
Has Abstractpub_date
1998-02-13 00:00:00pages
85-8issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(98)00032-9journal_volume
242pub_type
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