Abstract:
:In this study we determined that cholinergic neurons from the lateral dorsal tegmental (LDT) and peribrachial pontine region (PPG) innervate the medial pontine reticular formation (medial PRF), a region involved in the generation of REM sleep. Wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP) was injected into the medial PRF and the brainstem tissue was processed using a combined retrograde transport/immunocytochemical procedure. Results showed that 10-15% of choline acetyltransferase (ChAT) immunoreactive neurons in the LDT and PPG project to the medial PRF. It is hypothesized that these neurons play an important role in the generation of the REM sleep state.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Shiromani PJ,Armstrong DM,Gillin JCdoi
10.1016/0304-3940(88)90625-8subject
Has Abstractpub_date
1988-12-19 00:00:00pages
19-23issue
1-3eissn
0304-3940issn
1872-7972pii
0304-3940(88)90625-8journal_volume
95pub_type
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