Abstract：
:Glucose is an important metabolic factor controlling feeding behavior. There is evidence that physiologically relevant glucose sensors reside in the caudal hindbrain. The area postrema (AP) in particular, which has been characterized as a receptive site for the anorectic hormone amylin, may monitor blood glucose levels. To determine whether glucose and amylin co-activate the same subset of AP neurons, we performed extracellular single unit recordings from a rat AP slice preparation. In 53% of all AP neurons tested (n=32), the activity was positively correlated to the glucose concentration. Interestingly, there was a coincidental sensitivity (94%) of AP neurons to glucose and amylin, which exerted excitatory effects on these cells. We conclude that the co-sensitivity of AP neurons to glucose and amylin, both increasing in response to food intake, points to the AP as an important hindbrain center for the integration of the metabolic and hormonal control of nutrient intake.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Riediger T,Schmid HA,Lutz TA,Simon Edoi
10.1016/s0304-3940(02)00482-2keywords:
subject
Has Abstractpub_date
2002-08-09 00:00:00pages
121-4issue
2eissn
0304-3940issn
1872-7972pii
S0304394002004822journal_volume
328pub_type
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