Abstract:
:MicroRNAs, such as miR-34, have been reported to influence age-related diseases. In this study, we explored the role of the miR-34a/Bcl-2 signaling pathway in age-related hearing loss (AHL). Using an AHL mouse model (C57BL/6), we found that the expression of miR-34a in the cochlea increased with age, whereas expression of Bcl-2 decreased. Increasing the amount of a miR-34a mimetic in a mouse auditory cell line (HEI-OC1) inhibited Bcl-2, leading to enhanced apoptosis; in contrast, miR-34a inhibition produced the opposite effect. Our results support a link between age-related cochlear hair cell apoptosis and miR-34a/Bcl-2 signaling. The latter may thus serve as a potential target for AHL therapy.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Huang Q,Zheng Y,Ou Y,Xiong H,Yang H,Zhang Z,Chen S,Ye Ydoi
10.1016/j.neulet.2017.07.044subject
Has Abstractpub_date
2017-11-20 00:00:00pages
51-56eissn
0304-3940issn
1872-7972pii
S0304-3940(17)30616-Xjournal_volume
661pub_type
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