Abstract:
:The medial septal area (MSA) contains cholinergic and GABAergic neurons that send projections to the hippocampus. These neurons have both cholinergic and GABAergic receptors. This study was designed to determine the effects of intraseptal infusions of cholinergic and GABAergic drugs, which alter mnemonic processes, on hippocampal acetylcholine (ACh) release. Hippocampal ACh release was assessed using in vivo microdialysis and HPLC-EC. Oxotremorine and scopolamine produced a dose-dependent decrease in hippocampal ACh release. Muscimol decreased hippocampal ACh release at both high and low doses, although not in a dose-dependent manner. The effects of scopolamine and muscimol are consistent with a role of ACh in mnemonic processing.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Gorman LK,Pang K,Frick KM,Givens B,Olton DSdoi
10.1016/0304-3940(94)90485-5subject
Has Abstractpub_date
1994-01-31 00:00:00pages
199-202issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(94)90485-5journal_volume
166pub_type
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