Nardosinone, a novel enhancer of nerve growth factor in neurite outgrowth from PC12D cells.

abstract：:Transforming growth factor-β (TGF-β) is an anti-inflammatory cytokine and is expressed in the injured spinal cord. TGF-β signals through receptors to activate Smad proteins, which translocate into the nucleus. In the present study, we investigated the chronological alterations and cellular locations of the TGF-β/Smad ...

journal_title：Neuroscience letters

authors： Joko M,Osuka K,Usuda N,Atsuzawa K,Aoyama M,Takayasu M

更新日期：2013-08-09 00:00:00

abstract：OBJECTIVE:Study the effect of ephedrine on neural plasticity of hypoxic ischemic brain damaged (HIBD) in neonatal rats, and explore the underlying molecular mechanism. METHODS:60 Sprats suffered from HIBD (7 days old) were randomly divided into ephedrine group, D-amphetamine (D-AMPH) group, cytidine triphosphate (CTP)...

journal_title：Neuroscience letters

authors： Xiao N,Li S,Zhang X,Chen S

更新日期：2008-04-18 00:00:00

abstract：:We used whole-head magnetoencephalography to investigate cortical activity during two oromotor activities foundational to speech production. 13 adults performed mouth opening and phoneme (/pa/) production tasks to a visual cue. Jaw movements were tracked with an ultrasound-emitting device. Trials were time-locked to b...

journal_title：Neuroscience letters

authors： Memarian N,Ferrari P,Macdonald MJ,Cheyne D,De Nil LF,Pang EW

更新日期：2012-10-03 00:00:00

abstract：:We describe a new model of neurogenic pulmonary edema in spinal cord injured Wistar male rats. The pulmonary edema was elicited by an epidural thoracic balloon compression spinal cord lesion, performed under a low concentration of isoflurane (1.5 or 2%) in air. Anesthesia with 1.5% isoflurane promoted very severe inte...

journal_title：Neuroscience letters

authors： Sedý J,Urdzíková L,Likavcanová K,Hejcl A,Jendelová P,Syková E

更新日期：2007-08-16 00:00:00

abstract：:The Heat Shock Factors (HSFs) have been historically identified as a family of transcription factors that are activated and work in a stress-responsive manner, after exposure to a large variety of stimuli. However, they are also critical in normal conditions, in a life long manner, in a number of physiological process...

journal_title：Neuroscience letters

authors： Duchateau A,de Thonel A,El Fatimy R,Dubreuil V,Mezger V

更新日期：2020-04-23 00:00:00

abstract：:Using a reproducible two-vessel occlusion model for forebrain ischemia in rats, we investigated the temporal and spatial changes of vascular endothelial growth factor (VEGF) expression after transient forebrain ischemia with Northern blot analysis and in situ hybridization. Northern blot analysis revealed that VEGF mR...

journal_title：Neuroscience letters

authors： Lee MY,Ju WK,Cha JH,Son BC,Chun MH,Kang JK,Park CK

更新日期：1999-04-16 00:00:00

abstract：:Erythropoietin (EPO) and its specific receptor (EPOR) have been proposed to act as an endogenous system protecting against neuronal injury and neurodegeneration. We measured EPO in cerebrospinal fluid (CSF) of patients with neurodegenerative diseases, and tested for a correlation with an established biomarker of neuro...

journal_title：Neuroscience letters

authors： Brettschneider J,Widl K,Ehrenreich H,Riepe M,Tumani H

更新日期：2006-09-01 00:00:00

abstract：:Studies in humans use blood lactate to determine the degree of the exercise intensity, suggesting that exercise with elevated blood lactate concentrations results in increased BDNF plasma concentrations. However, it is not clear if lactate per se or rather other mechanisms are responsible for changes in blood BDNF con...

journal_title：Neuroscience letters

authors： Schiffer T,Schulte S,Sperlich B,Achtzehn S,Fricke H,Strüder HK

更新日期：2011-01-25 00:00:00

abstract：:We have demonstrated the existence and localization of two angiotensin II (AII) receptor subtypes in different regions of the rat brain using competitive radioligand binding technique. The identification of the subtypes was made by the reciprocal selectivity of DuP 753 and PD123177 for the AII-1 and AII-2 receptors, r...

journal_title：Neuroscience letters

authors： Leung KH,Smith RD,Pieter,Timmermans BM,Chiu AT

更新日期：1991-02-11 00:00:00

abstract：:We have previously shown that D-cycloserine displaces [3H]glycine binding to a recognition site with properties consistent with an N-methyl-D-aspartate (NMDA) receptor modulatory site. Additionally, D-cycloserine positively modulates the NMDA receptor as evidenced by its dose-dependent enhancement of [3H]1-[1-(2-thien...

journal_title：Neuroscience letters

authors： Hood WF,Compton RP,Monahan JB

更新日期：1989-03-13 00:00:00

abstract：:The perception of global coherent motion perception in complex motion patterns containing different direction vectors was investigated. Random dot kinematograms (RDK), plaids and fragmented plaid pattern were presented in which direction vectors of the moving elements were varied. In order to elicit coherent motion pe...

journal_title：Neuroscience letters

authors： Niedeggen M,Wist ER

更新日期：1998-04-24 00:00:00

abstract：:Bradykinin, an inflammatory mediator produced from plasma kallikreins, has potent effects on vascular functions, including increasing plasma extravasation and vasodilation. Attenuation in the response (desensitization to maintained exposure or tachyphylaxis to repeated administration) to bradykinin actions on synovial...

journal_title：Neuroscience letters

authors： Miao FJ,Khasar SG,Green PG,Levine JD

更新日期：1996-04-19 00:00:00

abstract：:Phencyclidine (PCP) abuse is reaching alarming proportions. PCP has recently been shown to induce hypertensive encephalopathies, microvascular cerebrovasospasm and acute intracerebral hemorrhage. Since we have shown in vitro that cerebral vasospasms induced by PCP could be completely reversed, or prevented, by use of ...

journal_title：Neuroscience letters

authors： Huang QF,Gebrewold A,Altura BT,Altura BM

更新日期：1990-05-18 00:00:00

abstract：:Functioning of the hypothalamo-pituitary-adrenocortical axis was assessed in rats treated with DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine), a selective noradrenergic neurotoxin. Although adrenal weights were slightly increased 10 days after DSP-4 injection, basal plasma corticosterone levels were unaltered co...

journal_title：Neuroscience letters

authors： Dooley DJ,Hunziker G,Häusler A

更新日期：1984-05-18 00:00:00

abstract：:DJ-1, the causative gene of a familial form of Parkinson's disease (PD), has been reported undergo oxidation preferentially at the 106th cysteine residue (Cys-106) under oxidative stress. Recently, it has been found that the levels of oxidized DJ-1 in erythrocytes of unmedicated PD patients are markedly higher than th...

journal_title：Neuroscience letters

authors： Akazawa YO,Saito Y,Hamakubo T,Masuo Y,Yoshida Y,Nishio K,Shichiri M,Miyasaka T,Iwanari H,Mochizuki Y,Kodama T,Noguchi N,Niki E

更新日期：2010-10-15 00:00:00

abstract：:Monosynaptic evoked field potentials (EPs) in response to paired-pulse stimulation (20 ms interval) were recorded in area CA1 and fascia dentata of the same animal in the course of development of a kindled focus in the CA1 region. A significant reduction of paired pulse depression in response to medium and high stimul...

journal_title：Neuroscience letters

authors： Kamphuis W,Gorter JA,Wadman WJ,Lopes da Silva FH

更新日期：1992-07-06 00:00:00

abstract：:Parkinson's disease (PD) may be initiated or precipitated by endogenous toxins with a structure similar to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in genetically-predisposed individuals. Nicotinamide N-methyltransferase (NNMT) catalyzes N-methylation of nicotinamide and other pyridines to form pyridinium ions. Th...

journal_title：Neuroscience letters

authors： Aoyama K,Matsubara K,Kondo M,Murakawa Y,Suno M,Yamashita K,Yamaguchi S,Kobayashi S

更新日期：2001-01-26 00:00:00

abstract：:In order to search for compounds mimicking the neurotrophic activities, a series of substances possessing the guanidine group of isaxonine (2-isopropylamino-pyrimidine), were synthesized and tested for their ability to induce neurite outgrowth in cultures of explants of rat dorsal root ganglia. It is reported that sev...

journal_title：Neuroscience letters

authors： Lehmann S,Quirosa-Guillou C,Becherer U,Thal C,Zanetta JP

更新日期：1993-04-02 00:00:00

abstract：:The synaptic relationships between gamma-aminobutyric acid (GABA)-immunoreactive and enkephalin-immunoreactive profiles in the cat spinal cord were examined using combined pre-embedding immunoperoxidase and post-embedding immunogold electron microscopic immunocytochemistry. Although colchicine was not used, enkephalin...

journal_title：Neuroscience letters

authors： Liu H,Llewellyn-Smith IJ,Pilowsky P,Basbaum AI

更新日期：1992-04-13 00:00:00

abstract：:The calcitonin-gene receptor peptide (alphaCGRP) receptor is present in high levels in the caudal striatum of the rat. Previous behavioural experiments have highlighted a possible correlation between alphaCGRP-mediated effects and the dopaminergic system. In this study, we examined the effect of alphaCGRP on K(+)-evok...

journal_title：Neuroscience letters

authors： Maneuf YP,McKnight AT

更新日期：2001-09-14 00:00:00

abstract：:The presence of the neuron specific enolase (NSE) has been tested by sandwich enzyme immunoassay in cerebrospinal fluid (CSF) of rats after intrastriatal injection of various amounts of kainic acid (KA). Incremental release of NSE was observed in CSF for increasing concentrations of injected KA. Still, a significant d...

journal_title：Neuroscience letters

authors： Steinberg R,Scarna H,Pujol JF

更新日期：1984-03-23 00:00:00

abstract：:Unilateral transtympanic administration of the sodium channel blocker tetrodotoxin (75 microl of 3 mM TTX in 0.1 M citrate buffer, pH 5.0) produced behavioral symptoms indicative of unilateral vestibular disruption. Following survival times of 2 and 24 h immunocytochemistry for Fos revealed asymmetric labeling in the ...

journal_title：Neuroscience letters

authors： Saxon DW

更新日期：2003-03-13 00:00:00

abstract：:Activation of the complement system is believed to be involved in degenerative processes of certain neurological diseases, including Alzheimer disease. Recent data have shown that the mRNAs for these proteins can be detected in brain-derived mRNA. In this study, C4 mRNA was detected by polymerase chain reaction (PCR) ...

journal_title：Neuroscience letters

authors： Walker DG,McGeer PL

更新日期：1993-07-09 00:00:00

abstract：:Twelve human subjects performed a reciprocal precision aiming task of varying difficulty (index of difficulty=4, 5, or 6) while vision of the ongoing movement was available either continuously or intermittently. In the intermittent conditions, vision of the moving end-effector was available at regular intervals (equal...

journal_title：Neuroscience letters

authors： Bootsma RJ,Boulard M,Fernandez L,Mottet D

更新日期：2002-11-22 00:00:00

abstract：:The human brain is a complex network that is known to be affected by normal aging. Graph-based analysis has been used to estimate functional brain network efficiency and effects of normal aging on small-worldness have been reported. This relationship is further investigated here along with network modularity, a statis...

journal_title：Neuroscience letters

authors： Onoda K,Yamaguchi S

更新日期：2013-11-27 00:00:00

abstract：:Cystathionine beta synthase (CBS) is the main contributor to the production of hydrogen sulfide (H2S) in the brain. Exogenously administered H2S has been reported to protect neurons against hypoxic injury, ischemia and LPS-induced neuro-inflammation and in the facilitating of long term potentiation (LTP). Dysregulatio...

journal_title：Neuroscience letters

authors： Bruintjes JJ,Henning RH,Douwenga W,van der Zee EA

更新日期：2014-03-20 00:00:00

abstract：:Crickets (Gryllus bimaculatus) use the cercal sensory system at the rear of the abdomen to detect air currents and direct predator avoidance behavior. Sensory information regarding the direction and dynamic properties of air currents is processed within the terminal abdominal ganglion, and conveyed by ascending giant ...

journal_title：Neuroscience letters

authors： Ogawa H,Kajita Y

更新日期：2015-01-01 00:00:00

abstract：:We examined the effects of chronic in vivo antipsychotic drug treatments on G protein function and regulation. Mice were treated with typical antipsychotic haloperidol (6 mg/kg per day) and atypical agent olanzapine (20 mg/kg per day) for 14 days via mini-osmotic pumps. G protein-activated adenylyl cyclase activity in...

journal_title：Neuroscience letters

authors： Kaplan GB,Leite-Morris KA,Keith DJ

更新日期：1999-10-08 00:00:00

abstract：:Mice were treated with N-2-chloroethyl-N-ethyl-2-bromobenzylamine hydrochloride (DSP4), which causes severe noradrenaline (NA) depletions in brain regions and the spinal cord, or vehicle i.p. They were tested 14 days later for antinociception induced by intrathecal injections of different doses of NA. A potentiation o...

journal_title：Neuroscience letters

authors： Post C,Arweström E,Minor BG,Wikberg JE,Jonsson G,Archer T

更新日期：1985-08-16 00:00:00

abstract：:The function of Merkel cells in mechanotransduction has remained controversial Single unit recordings were made from Merkel cell receptors (sinus hair type I, St I) and another slowly adapting mechanoreceptor (sinus hair type II, St II) in isolated rat sinus hairs by applying controlled mechanical displacements to the...

journal_title：Neuroscience letters

authors： Senok SS,Halata Z,Baumann KI

更新日期：1996-08-23 00:00:00