Abstract:
:We describe a new model of neurogenic pulmonary edema in spinal cord injured Wistar male rats. The pulmonary edema was elicited by an epidural thoracic balloon compression spinal cord lesion, performed under a low concentration of isoflurane (1.5 or 2%) in air. Anesthesia with 1.5% isoflurane promoted very severe interstitial and intraalveolar neurogenic pulmonary edema with a significantly increased thickness of the alveolar walls and massive pulmonary hemorrhage. In this group, 33% of animals died. Anesthesia with 2% isoflurane promoted severe interstitial and intraalveolar neurogenic pulmonary edema with less thickening of the alveolar walls and pulmonary hemorrhage. For evoking severe neurogenic pulmonary edema in spinal cord injured rats, 2% isoflurane anesthesia would be more suitable. However, if very severe neurogenic pulmonary edema needs to be evoked, spinal cord injury under 1.5% isoflurane anesthesia could be used, but one-third of the animals will be lost.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Sedý J,Urdzíková L,Likavcanová K,Hejcl A,Jendelová P,Syková Edoi
10.1016/j.neulet.2007.06.053subject
Has Abstractpub_date
2007-08-16 00:00:00pages
167-71issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(07)00748-3journal_volume
423pub_type
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