A new model of severe neurogenic pulmonary edema in spinal cord injured rat.

Abstract:

:We describe a new model of neurogenic pulmonary edema in spinal cord injured Wistar male rats. The pulmonary edema was elicited by an epidural thoracic balloon compression spinal cord lesion, performed under a low concentration of isoflurane (1.5 or 2%) in air. Anesthesia with 1.5% isoflurane promoted very severe interstitial and intraalveolar neurogenic pulmonary edema with a significantly increased thickness of the alveolar walls and massive pulmonary hemorrhage. In this group, 33% of animals died. Anesthesia with 2% isoflurane promoted severe interstitial and intraalveolar neurogenic pulmonary edema with less thickening of the alveolar walls and pulmonary hemorrhage. For evoking severe neurogenic pulmonary edema in spinal cord injured rats, 2% isoflurane anesthesia would be more suitable. However, if very severe neurogenic pulmonary edema needs to be evoked, spinal cord injury under 1.5% isoflurane anesthesia could be used, but one-third of the animals will be lost.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Sedý J,Urdzíková L,Likavcanová K,Hejcl A,Jendelová P,Syková E

doi

10.1016/j.neulet.2007.06.053

subject

Has Abstract

pub_date

2007-08-16 00:00:00

pages

167-71

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(07)00748-3

journal_volume

423

pub_type

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