Staurosporine and H7 attenuate ethanol-induced elevation in [Ca2+]i in cultured canine cerebral vascular smooth muscle cells.

abstract：BACKGROUND:The etiology of neurodegenerative disease remains unclear. Recently, SNP rs11868035, located in an intron of the sterol regulatory element binding factor (SREBF1) gene, was found to be associated with Parkinson's disease (PD) in a large European population in a genome-wide association study. To examine the p...

journal_title：Neuroscience letters

authors： Yuan X,Cao B,Wu Y,Chen Y,Wei Q,Ou R,Yang J,Chen X,Zhao B,Song W,Shang H

更新日期：2018-01-18 00:00:00

abstract：:Loss of ganglion cells is a common and irreversible complication of hair cell loss in the cochlea. Gene transfer could potentially be used to prevent this neuronal degeneration and other pathologies in the cochlea. Human adenoviruses should provide a feasible gene transfer vehicle for transducing the quiescent cochlea...

journal_title：Neuroscience letters

authors： Raphael Y,Frisancho JC,Roessler BJ

更新日期：1996-03-29 00:00:00

abstract：:The effect of intracerebroventricular (i.c.v.) injection of brain natriuretic peptide (BNP), a novel peptide purified from the porcine brain, on arginine vasopressin (AVP) secretion was studied in conscious, unrestrained rats and was compared with that of atrial natriuretic polypeptide (ANP). I.c.v. administration of ...

journal_title：Neuroscience letters

authors： Yamada T,Nakao K,Itoh H,Shirakami G,Kangawa K,Minamino N,Matsuo H,Imura H

更新日期：1988-12-19 00:00:00

abstract：:The effects of i.v. administration of thyrotropin releasing hormone (TRH) on regional cerebral blood flow (rCBF) were examined in both healthy adult (3-5 months old) and healthy aged (24-25 months old) male Wistar rats under halothane anesthesia. The rCBFs in 9 different brain regions-cerebral cortex, caudate putamen,...

journal_title：Neuroscience letters

authors： Inanami O,Ohno K,Sato A

更新日期：1992-08-31 00:00:00

abstract：:The binding and pharmacological characteristics of [125I]iodomelatonin binding sites in human fetal brain membrane preparations were determined. Membrane preparations of the whole brain revealed a equilibrium binding constant (Kd) of 17.5 pmol/l with a total number of binding sites (Bmax) at 0.8 fmol/mg protein. Among...

journal_title：Neuroscience letters

authors： Yuan H,Lu Y,Pang SF

更新日期：1991-09-16 00:00:00

abstract：:The central cardiovascular effects of neuropeptide Y (NPY) have been investigated by microinjection of the peptide into the hypothalamic paraventricular nucleus (PVN) of conscious rats. NPY (100 ng) elicited a significant bradycardia in both Long Evans (control) rats (-27 +/- beats/min) and vasopressin-deficient Bratt...

journal_title：Neuroscience letters

authors： Harland D,Bennett T,Gardiner SM

更新日期：1988-02-29 00:00:00

abstract：:Effects of anxiety on perceptual-motor organisation of rhythmical forearm movements were examined using an interrupted time series design with staggered baselines. Participants were exposed to repeated baseline sessions interrupted with two anxiety-inducing sessions. Results showed that under moderate levels of anxiet...

journal_title：Neuroscience letters

authors： Court ML,Bennett SJ,Williams AM,Davids K

更新日期：2005-08-12 00:00:00

abstract：:Bone mesenchymal stem cells (BMSCs) are an attractive donor graft source because of the potential of self-renewal and multi-direction differentiation. However, it is a great challenge to induce BMSCs to specifically differentiate to dopamine (DA) neurons for the treatment of Parkinson's disease. Because the striatum i...

journal_title：Neuroscience letters

authors： Yang S,Gao Q,Bao L,Zhang J,Hu Y,Bing L,Sun J,Hao J,Chen C,Li S,Poon WS,Sun J,Gao Y

更新日期：2012-11-21 00:00:00

abstract：:Despite the crucial importance of direction of gaze in social interactions, it is only recently that there has been interest in human brain responses to gaze direction. Using full-head magnetoencephalography, we investigated the correlates of direction of gaze in full faces and in eyes-only stimuli, measuring the earl...

journal_title：Neuroscience letters

authors： Taylor MJ,George N,Ducorps A

更新日期：2001-12-28 00:00:00

abstract：:We have previously demonstrated that repeated exposure of adult rat hippocampal slices to brief episodes of hypoxia induce a sustained decrease in the threshold of stimulus-evoked population spike discharges in CA1 pyramidal neurons [O. Godukhin, A. Savin, S. Kalemenev, S. Levin, Neuronal hyperexcitability induced by ...

journal_title：Neuroscience letters

authors： Levin S,Godukhin O

更新日期：2005-03-22 00:00:00

abstract：:This study concerns the effect of intravitreal injection of 1-methyl-4-phenylpyridinium ion (MPP+) on the electroretinograms (ERG) and on the levels of retinal dopamine (DA) in rabbits. The right eye was injected intravitreously with MPP+ while the other received only the vehicle and served as control. The administrat...

journal_title：Neuroscience letters

authors： Harnois C,Marcotte G,Daigle M,Di Paolo T

更新日期：1989-12-15 00:00:00

abstract：:Retinal action potential (RAP) was recorded at different depths in the median eye of scorpion, using a glass micropipette electrode (tip diameter 2-3 mum). The amplitude of RAP was largest when the tip of the electrode touched the distal process of the receptor cell (RC). The polarity of RAP became reversed when the t...

journal_title：Neuroscience letters

authors： Ramakrishna T

更新日期：1977-06-01 00:00:00

abstract：:In vitro quantitative autoradiography was used to visualize nicotinic receptors in large cryosections of human brain hemispheres. Sections 80 microns thick of human brain hemispheres were incubated with (-)-[3H]nicotine and the distribution of nicotinic receptors in human brain was studied. Increasing numbers of nicot...

journal_title：Neuroscience letters

authors： Adem A,Nordberg A,Jossan SS,Sara V,Gillberg PG

更新日期：1989-07-03 00:00:00

abstract：:Although rats often show an upright standing behavior the cardiovascular response during the behavior has not yet been fully clarified. In this study we quantified the activity of upright standing behavior in rats using infrared beam detectors and measured cardiovascular variables during the behavior. Rats demonstrate...

journal_title：Neuroscience letters

authors： Waki H,Katahira K,Yamasaki M,Katsuda S,Shimizu T,Maeda M

更新日期：2009-01-02 00:00:00

abstract：:In order to study the influence of curare and atropine on the gamma-aminobutyric acid (GABA)-evoked chloride current, we have investigated cultures of hippocampal and septal region neurons from embryonic rats (E18). The neurons were cultured under the trophic influence of spatially separated astrocytes in serum-free m...

journal_title：Neuroscience letters

authors： Siebler M,Köller H,Schmalenbach C,Müller HW

更新日期：1988-11-11 00:00:00

abstract：:The cellular localization of butyrylcholinesterase (E,C 3.1.1.8) in rat cerebellum was determined by immunofluorescence with a monospecific immune serum raised against rat brain butyrylcholinesterase. The antiserum specifically stains only glial cells. ...

journal_title：Neuroscience letters

authors： Barth F,Ghandour MS

更新日期：1983-08-29 00:00:00

abstract：:The effect of capsaicin was studied on non-cholinergic inhibitory postsynaptic currents (IPSC). The experiments were performed on an identified snail neurone using the single electrode voltage-clamp technique. The IPSC decayed with a bi-exponential time course. Capsaicin (200 microM) reversibly blocked both components...

journal_title：Neuroscience letters

authors： Erdélyi L,Such G

更新日期：1984-03-09 00:00:00

abstract：:Manual actions and speech are connected: for example, grip execution can influence simultaneous vocalizations and vice versa. Our previous studies show that the consonant [k] is associated with the power grip and the consonant [t] with the precision grip. Here we studied whether the interaction between speech sounds a...

journal_title：Neuroscience letters

authors： Tiainen M,Tiippana K,Paavilainen P,Vainio M,Vainio L

更新日期：2017-06-09 00:00:00

abstract：:Heat shock protein 70 family was demonstrated to play a critical role in protein homeostasis, a process profoundly impaired in neurodegenerative disorders. Neurodegenerative diseases are characterized by the accumulation of different kind of proteins and the formation of insoluble aggregates which are toxic for neuron...

journal_title：Neuroscience letters

authors： Sirtori R,Riva C,Ferrarese C,Sala G

更新日期：2020-09-25 00:00:00

abstract：:Using specific radioimmunoassays, melatonin was quantified in the aqueous humor and serum of male pigmented rabbits adapted to 12L:12D with lights on at 06.00 h. Melatonin concentrations in the aqueous humor at 08.00 and 16.00 h were similar (mean: 5.23 pg/ml) and significantly lower than those at 22.00 and 01.00 h (m...

journal_title：Neuroscience letters

authors： Yu HS,Yee RW,Howes KA,Reiter RJ

更新日期：1990-08-24 00:00:00

abstract：:Distributions of one sensory and 13 motor axons to intrafusal fibers in a human spindle from the biceps brachii muscle were reconstructed from serial, 1 micron thick transverse sections. The primary afferent was distributed predominantly to nuclear bag fibers. Motor innervation in the human spindle was characterized b...

journal_title：Neuroscience letters

authors： Kucera J

更新日期：1986-01-16 00:00:00

abstract：:Bone-conducted ultrasound (BCU) modulated by speech sound is recognized as speech sound and activates the auditory cortex similar to audible sound. To investigate the mechanisms of perception, the effects of stimulus duration on N1m were compared among air-conducted audible speech sound (AC speech), AC speech with car...

journal_title：Neuroscience letters

authors： Okayasu T,Nishimura T,Yamashita A,Nakagawa S,Nagatani Y,Yanai S,Uratani Y,Hosoi H

更新日期：2011-05-09 00:00:00

abstract：:The sexual axis of rats can be rendered photoresponsive by testosterone implants. We have studied in these conditions whether rat pars tuberalis (PT) melatonin receptor density would be decreased after exposure to short photoperiod (SP) like as observed in long day seasonal breeders. The answer is no, but we observed ...

journal_title：Neuroscience letters

authors： Recio J,Pévet P,Míguez JM,Masson-Pévet M

更新日期：1996-08-16 00:00:00

abstract：:Although synaptically released, vesicular Zn(2+) has been proposed to play a neuromodulatory or neuronal signaling role at the mossy fiber-CA3 synapse, Zn(2+) release remains controversial, especially when detected using fluorescent imaging. In the present study, we investigated synaptically released Zn(2+) at the mos...

journal_title：Neuroscience letters

authors： Bastian C,Li YV

更新日期：2007-05-29 00:00:00

abstract：:Compared to other M(1) muscarinic acetylcholine receptor (M(1) mAChR) agonists, xanomeline demonstrates both reversible and persistent modes of binding to the receptor. In our study, we investigated the long-term consequences of brief incubation of Chinese hamster ovary cells expressing M(1) mAChR (M(1)-CHO) with low ...

journal_title：Neuroscience letters

authors： De Lorme KC,Sikorski KL,Grant MK,El-Fakahany EE

更新日期：2006-12-13 00:00:00

abstract：:On anesthetized adult rats, we examined the possibility that the discharges of spinocerebellar Purkinje cells (PCs) are modulated by passive limb positioning. The rat forelimb was passively placed in four different sagittal positions while the simple spike spontaneous activity of single PCs was recorded; recordings st...

journal_title：Neuroscience letters

authors： Giaquinta G,Casabona A,Valle MS,Bosco G,Perciavalle V

更新日期：1998-04-03 00:00:00

abstract：:The cognitive deficits observed in schizophrenia are considered a core feature of the disease. Neuregulin-1 is a risk gene for schizophrenia that is involved in many neurodevelopmental and synaptic plasticity-related processes relevant to schizophrenia. Here, we have utilized a rat model (Nrg1(Tn)), which is hypomorph...

journal_title：Neuroscience letters

authors： Taylor AR,Taylor SB,Koenig JI

更新日期：2012-12-07 00:00:00

abstract：:The presence of neuromelanic pigment in neurons of the rat substantia nigra (SN) is a matter of controversy. The presence of neuromelanin in the SN of 15--24-month-old rats was investigated by electron microscopy (EM) and the findings compared to the morphology and distribution of neuromelanin in SN of dogs. In the ra...

journal_title：Neuroscience letters

authors： DeMattei M,Levi AC,Fariello RG

更新日期：1986-12-03 00:00:00

abstract：:The efficacy of acetylcholine muscarinic M2 receptor-G protein coupling was investigated in Alzheimer's disease and control neocortical membranes by measuring the effects of MgCl2 and 5'-guanylylimidodiphosphate (Gpp[NH]p) on high-affinity [3H]oxotremorine-M ([3H]OXO-M) binding. MgCl2 gave similar enhancements of [3H]...

journal_title：Neuroscience letters

authors： Hérnandez-Hérnandez A,Adem A,Ravid R,Cowburn RF

更新日期：1995-02-15 00:00:00

abstract：:The number of neurons in the primary motor cortex (MI) and the primary somatosensory cortex (SI) were estimated in the same locations of brains from sporadic amyotrophic lateral sclerosis (ALS) cases and controls. The number of MI and SI neurons and Betz cells were significantly decreased in the ALS cases as compared ...

journal_title：Neuroscience letters

authors： Mochizuki Y,Mizutani T,Shimizu T,Kawata A

更新日期：2011-09-26 00:00:00