Abstract:
:The neuritogenic activity of human peripheral nerve myelin proteins in Lewis rats was examined. Experimental allergic neuritis (EAN) was induced by human myelin fraction in all Lewis rats examined. Purified human P2 protein induced mild but definite EAN. None of purified P0 protein, total myelin lipids, gangliosides and cerebrosides induced EAN. Addition of total myelin lipids or gangliosides to the P2 protein did not enhance the neuritogenicity of the P2 protein. Bovine P2 protein, which was inactive in rabbits and guinea pigs, showed considerable neuritogenicity in Lewis rats. We postulate that induction of EAN depends both on the species of host animal and the source of antigen.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Suzuki M,Kitamura K,Uyemura K,Ogawa Y,Ishihara Y,Matsuyama Hdoi
10.1016/0304-3940(80)90287-6subject
Has Abstractpub_date
1980-10-02 00:00:00pages
353-8issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(80)90287-6journal_volume
19pub_type
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