Loss of high-affinity alpha 2-adrenoceptors in Alzheimer's disease: an autoradiographic study in frontal cortex and hippocampus.

Abstract:

:We assessed, by quantitative autoradiography, the density of high-affinity alpha 2-adrenoceptors in hippocampus and frontal cortex sections from 18 patients dying with Alzheimer's disease (AD) in comparison with a control group of 13 matched cases. The full agonist [3H]bromoxidine (UK-14304) was used as a ligand. In AD brains, the specific binding of [3H]bromoxidine was markedly decreased both in frontal cortex, the reduction ranging from 55% on layer I (P less than 0.0005) to 40% loss on layers IV-VI (P less than 0.01), and in the hippocampus where the mean of alpha 2-receptor loss was 53% both for the CA1 (P less than 0.0005) and the dentate gyrus (P less than 0.005). This dramatic decrease in the density of functional, high-affinity alpha 2-adrenoceptors very probably reflects the neuronal loss described in locus coeruleus of AD brains. The important implications of these findings for the pharmacological treatment of AD are discussed.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Pascual J,Grijalba B,García-Sevilla JA,Zarranz JJ,Pazos A

doi

10.1016/0304-3940(92)90614-d

keywords:

subject

Has Abstract

pub_date

1992-08-03 00:00:00

pages

36-40

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(92)90614-D

journal_volume

142

pub_type

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