Phencyclidine reduces postischemic neuronal necrosis in rat hippocampus without changing blood flow.

abstract：:Telmisartan is an angiotensin II type 1 receptor blocker and partial agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ). Here, we investigated the protective capacity of telmisartan against high glucose (HG)-elicited oxidative damage in PC12 cells. The activity of lactate dehydrogenase (LDH), NADPH o...

journal_title：Neuroscience letters

authors： Eslami H,Sharifi AM,Rahimi H,Rahati M

更新日期：2014-01-13 00:00:00

abstract：PURPOSE:To investigate the brain protective effects of fingolimod on inflammatory response of SAH mice. METHODS:We utilized an endovascular mouse perforation model of SAH. Mice were divided into three groups: sham group, SAH group and SAH + Fingolimod group. Mice received either saline or fingolimod (1 mg/kg) intraper...

journal_title：Neuroscience letters

authors： Wang Y,Zhou S,Han Z,Yin D,Luo Y,Tian Y,Wang Z,Zhang J

更新日期：2020-09-25 00:00:00

abstract：:Carbonic anhydrase (CA) activity was localized histochemically in the retina and brain of the honeybee drone. A positive reaction that could be inhibited with 10(-5) M acetazolamide was found only in brain glial cells such as those in the lamina and medulla of the optic lobes. In the retina, neither the photoreceptors...

journal_title：Neuroscience letters

authors： Walz B

更新日期：1988-02-15 00:00:00

abstract：:This study examined what changes occur in upper-limb bilateral coordination during clapping as the movement frequency requirements were increased to the maximum. Subjects were required to begin the clapping action at approximately 1Hz and gradually increase the movement speed until their maximal frequency was achieved...

journal_title：Neuroscience letters

authors： Morrison S,Hong SL,Newell KM

更新日期：2009-05-01 00:00:00

abstract：:In brainstem slices of guinea pigs perfused with artificial cerebro-spinal fluid (ACSF), the discharge of all the spontaneously active neurons of the medial vestibular nucleus (MVN) is regular. It has been reported that prolonged exposure to a low Ca(2+) medium could induce these neurons to fire bursts of spikes. In t...

journal_title：Neuroscience letters

authors： Ris L,Godaux E

更新日期：2001-01-12 00:00:00

abstract：:We measured levels of basal and norepinephrine (NE) -induced melatonin release in cultured pineal bodies of rats just after and 2 days after irradiation (20 or 200 Gy) or sham-irradiation. On the day of irradiation, basal and NE-induced melatonin release were not affected by irradiation. Two days after irradiation, ba...

journal_title：Neuroscience letters

authors： Saito K,Shinohara K,Morofushi M,Funabashi T,Mitsushima D,Hata M,Matsubara S,Kimura F

更新日期：2000-04-21 00:00:00

abstract：:The functional contribution of cloned subunits to insect nicotinic acetylcholine (ACh) receptors has been difficult to determine using heterologous expression. Instead, in this study we explore the subunit composition of naturally expressed functional receptors in an insect using RNA interference. The nicotinic alpha ...

journal_title：Neuroscience letters

authors： Vermehren A,Qazi S,Trimmer BA

更新日期：2001-11-09 00:00:00

abstract：:A free radical scavenger edaravone is clinically used in Japan for acute stroke, and several basic researches have carefully examined the mechanisms of edaravone's protective effects. However, its actions on pro-inflammatory responses under stroke are still understudied. In this study, we subjected adult male Sprague-...

journal_title：Neuroscience letters

authors： Fujiwara N,Som AT,Pham LD,Lee BJ,Mandeville ET,Lo EH,Arai K

更新日期：2016-10-28 00:00:00

abstract：:We are constantly exposed to symbols such as traffic signs, emoticons in internet communication, or other abstract representations of objects as well as, of course, the written words. However, aside from the word reading, little is known about the way our brain responds when we read non-lexical iconic symbols. By usin...

journal_title：Neuroscience letters

authors： Shin YW,Kwon JS,Kwon KW,Gu BM,Song IC,Na DG,Park S

更新日期：2008-05-16 00:00:00

abstract：:Generalized epilepsy with febrile seizures plus (GEFS(+)) is a common familial epilepsy syndrome, which generally develops in childhood. GEFS(+) is caused by mutations in the sodium-channel α1-subunit (SCN1A). In this report, we investigated a Chinese family with an autosomal dominant form of GEFS(+). The affected GEF...

journal_title：Neuroscience letters

authors： Cui X,Zeng F,Liu Y,Zhang J,Archacki S,Zhan T,Du R,Tang Z,Liu J,Wang QK,Liu M

更新日期：2011-09-26 00:00:00

abstract：:A mini-symposium (chaired by L. Chal, Australia, P. Lembeck, Austria, J. Szolcsányi, Hungary and M. Zimmermann, F.R.G.) was held in Bad Nauheim, F.R.G. on June 29, 1990, under the sponsorship of the European Neuropeptide Club, which focussed on recent advances of research on sensory peptides and mechanism of action of...

journal_title：Neuroscience letters

authors： Maggi CA,Pierau FK

更新日期：1991-01-28 00:00:00

abstract：:Reactive oxygen species (ROS), such as superoxide and hydrogen peroxide, play essential roles in physiological plasticity and are also involved in the pathogenesis of persistent pain. Roles of peripheral and spinal ROS in pain have been well established, but much less is known about ROS in the amygdala, a brain region...

journal_title：Neuroscience letters

authors： Lu YF,Neugebauer V,Chen J,Li Z

更新日期：2016-04-21 00:00:00

abstract：:Depressive disorders represent a significant health concern as they are associated with high social and physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective treatment for patients with drug-resistant severe depressive disorders. However, the underlying biological m...

journal_title：Neuroscience letters

authors： Fryland T,Elfving B,Christensen JH,Mors O,Wegener G,Børglum AD

更新日期：2012-05-10 00:00:00

abstract：:Both autoradiographic and horseradish peroxidase tracing techniques were used to characterize a projection from the dorsal lateral geniculate (DLG) nucleus of the thalamus to visual association cortex (extrastriate cortex) in the macaque monkey. The results show that medium to large caliber DLG axons end to discontinu...

journal_title：Neuroscience letters

authors： Yoshida K,Benevento LA

更新日期：1981-03-10 00:00:00

abstract：:Chewing and walking are two oscillatory behaviors performed on an everyday basis. The current study examined the impact chewing at different speeds (i.e. fast, slow, preferred) had on walking performance for fifteen young healthy adults (23.2 + 4.2 years) and fifteen healthy older participants (66.5 + 3.2 years). Chew...

journal_title：Neuroscience letters

authors： Samulski B,Prebor J,Armitano C,Morrison S

更新日期：2019-04-17 00:00:00

abstract：:This study explored whether patients with Parkinson's disease alter the regulation of upright standing according to constraints imposed by the environmental context. The provision of context-dependent adaptations was inferred from the presence of adjustments to standing postural control that would serve to reduce fall...

journal_title：Neuroscience letters

authors： Brown LA,Doan JB,Whishaw IQ,Suchowersky O

更新日期：2007-05-18 00:00:00

abstract：:Fear-conditioned analgesia (FCA) is modulated by brain areas involved in the descending inhibitory pain pathway such as the basolateral (BLA) and central amygdala (CEA). The BLA contains Ca2+/calmodulin-dependent protein kinase II (CaMKII) and parvalbumin (PV) neurons. CEA neurons are primarily inhibitory (GABAergic) ...

journal_title：Neuroscience letters

authors： Butler RK,Ehling S,Barbar M,Thomas J,Hughes MA,Smith CE,Pogorelov VM,Aryal DK,Wetsel WC,Lascelles BDX

更新日期：2017-11-20 00:00:00

abstract：:We have attempted to determine the effects of electroconvulsive shock (ECS) on protein phosphatase 2A (PP2A) in the frontal cortices of rats. PP2A exhibited a 30% increase in activity immediately after ECS treatment. Immunoblot analysis revealed that phosphorylation signals, including protein kinase B (Akt/PKB), glyco...

journal_title：Neuroscience letters

authors： Kang UG,Jeon WJ,Kim Y,Chung CK,Park JB,Juhnn YS,Kim YS

更新日期：2005-12-30 00:00:00

abstract：:In rats anesthetized with pentobarbital or a mixture of urethane and chloralose, horseradish peroxidase (HRP) was injected into the intermediolateral column of the spinal cord (Th7 and Th9) or the posterior pituitary lobe. HRP positive cells were found mainly in the dorsomedial part of the paraventricular nuclease (PV...

journal_title：Neuroscience letters

authors： Ono T,Nishino H,Sasaka K,Muramoto K,Yano I,Simpson A

更新日期：1978-11-01 00:00:00

abstract：:Bipolar disorder (BD) is a debilitating mental disorder with complex clinical manifestations and low diagnostic accuracy. Depressive episodes are most common in the course of BD with high comorbidity and suicide rates, which present greater clinical challenges than mania and hypomania episodes. However, there are no o...

journal_title：Neuroscience letters

authors： Ren Y,Chen ZZ,Sun XL,Duan HJ,Tian JS,Wang JY,Yang H

更新日期：2021-01-18 00:00:00

abstract：:A partially purified toxin obtained from the coral reef crab, Lophozozymus pictor was found to be a potent inhibitor of Na+-dependent [14C]-GABA uptake by rat brain synaptosomes. Inhibition was potentiated in the presence of external K+. The I50 value for the toxin was found to be in the region of 10 microgram/ml at a...

journal_title：Neuroscience letters

authors： Tan CH,Abkowitz SJ

更新日期：1979-10-01 00:00:00

abstract：:Olprinone, an inhibitor of cyclic nucleotide phosphodiesterase III, inhibited an increase in intracellular Ca(2+) concentrations for acutely dissociated rat hippocampal pyramidal neurons induced by extracellular high K(+) (35 mM) depolarization. Olprinone (100 microM) significantly reduced spontaneous glutamate releas...

journal_title：Neuroscience letters

authors： Fujikawa H,Kanno T,Nagata T,Nishizaki T

更新日期：2008-12-26 00:00:00

abstract：:The microscopic distribution of omega 3 (peripheral type benzodiazepine) binding sites in sections from normal and ischaemic rat brain has been determined by emulsion autoradiography with the photoaffinity ligand [3H]PK 14105. In the normal rat brain, high densities of omega 3 sites were present in the ependymal cells...

journal_title：Neuroscience letters

authors： Benavides J,Dubois A,Gotti B,Bourdiol F,Scatton B

更新日期：1990-06-22 00:00:00

abstract：:In urethane-anesthetized rats single neuronal activity was recorded in the laterodorsal tegmental nucleus (LDT), which has a dense complement of cholinergic neurons, and in the dorsal raphe and locus coeruleus for comparison. Most LDT neurons responded antidromically to stimulation of either one or more of several ros...

journal_title：Neuroscience letters

authors： Kayama Y,Ogawa T

更新日期：1987-06-26 00:00:00

abstract：:Alterations of Ca2+ homeostasis have been reported for both fibroblasts and T-lymphocytes of patients with Alzheimer's disease (AD). Considering the importance of K+ conductances for the cellular Ca2+ regulation and the recently reported absence of a K+ channel in Alzheimer fibroblasts, we investigated K+ currents in ...

journal_title：Neuroscience letters

authors： Cohen CD,Vollmayr B,Aldenhoff JB

更新日期：1996-01-05 00:00:00

abstract：:Rats were injected (i.p.) once daily with either 1 mg/kg CGP 56999A, a gamma-aminobutyric acid(B) (GABA(B)) receptor antagonist, or an equivalent volume of saline beginning 7 days prior to, and continuing for 7 days following, a unilateral 6-hydroxydopamine lesion of the nigrostriatal dopamine (DA) pathway. At the end...

journal_title：Neuroscience letters

authors： Enna SJ,Reisman SA,Stanford JA

更新日期：2006-10-02 00:00:00

abstract：:Hippocampal output is mediated via the subiculum, which is the principal target of CA1 pyramidal cells, and which sends projections to a variety of cortical and subcortical regions. Pyramidal cells in the subiculum display two different firing modes and are classified as being burst-spiking or regular-spiking. In a pr...

journal_title：Neuroscience letters

authors： Shor OL,Fidzinski P,Behr J

更新日期：2009-01-16 00:00:00

abstract：:Exercise increases the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus and beneficially contributes to cognitive function and is accompanied by epigenetic changes. Specifically, the activity levels of histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate histone acetylat...

journal_title：Neuroscience letters

authors： Li X,Inoue T,Hayashi M,Maejima H

更新日期：2019-07-27 00:00:00

abstract：:The dopaminergic system has a long history of being associated with reward-related activities but the developmental consequences of blocking dopamine receptor function on reward-based associative learning has been less studied. To this end, male, Long Evans rats were systemically (i.p.) treated with the dopamine recep...

journal_title：Neuroscience letters

authors： Holahan MR,Goheen K

更新日期：2020-04-23 00:00:00

abstract：:Oral administration of naloxone (10 mg/kg) antagonized the slowing of the intestinal transit caused by oral morphine (1, 2.5 and 5 mg/kg) in rats. Oral administration of naloxone (10 mg/kg) did not prevent the antinociceptive effect of orally administered morphine (2.5 mg/kg) in the tail-flick test carried out on rats...

journal_title：Neuroscience letters

authors： Jurna I,Kaiser R,Kretz O,Baldauf J

更新日期：1992-08-03 00:00:00