The phosphodiesterase III inhibitor olprinone inhibits hippocampal glutamate release via a cGMP/PKG pathway.

abstract：:The aim of the present study was to investigate whether mice with a deletion of the gene that encodes the protein kinase C gamma (PKC gamma) isoform could affect the G-protein activation mediated through the opioid receptor-like (ORL-1) receptor and mu-opioid receptor in the mouse pons/medulla and spinal cord, monitor...

journal_title：Neuroscience letters

authors： Narita M,Mizoguchi H,Khotib J,Suzuki M,Ozaki S,Yajima Y,Narita M,Tseng LF,Suzuki T

更新日期：2002-10-04 00:00:00

abstract：:Prior work demonstrated that immune surveillance of the brain occurs primarily through the blood-cerebrospinal (CSF) fluid barrier rather than the blood-brain barrier endothelium. Recently, we identified epithelial V-like antigen (EVA), an immunoglobulin-like adhesion molecule, as a regulator of blood-CSF barrier inte...

journal_title：Neuroscience letters

authors： Wojcik E,Carrithers LM,Carrithers MD

更新日期：2011-05-16 00:00:00

abstract：:DNA variation at the FGF20 gene has been associated with Parkinson's disease (PD). In particular, SNP rs12720208 in the 3' untranslated region (3' UTR) was linked to PD-risk through a mechanism that would implicate a differential binding to microRNA-433 (miR-433). The reduction of the affinity of miR-433 to the 3' UTR...

journal_title：Neuroscience letters

authors： de Mena L,Cardo LF,Coto E,Miar A,Díaz M,Corao AI,Alonso B,Ribacoba R,Salvador C,Menéndez M,Morís G,Alvarez V

更新日期：2010-07-19 00:00:00

abstract：:Human sweat and sebaceous glands were studied immunohistochemically with a monoclonal antibody recognizing a vasoactive intestinal polypeptide (VIP) receptor. The staining pattern correlated well with the known distribution of sympathetic VIP-containing nerves in the human skin. The luminal cell layer of the sweat gla...

journal_title：Neuroscience letters

authors： Kummer W,Herbst WM,Heym C

更新日期：1990-03-14 00:00:00

abstract：:The blood-brain barrier (BBB) plays an important role in controlling the passage of molecules from the blood to the extracellular fluid environment of the brain. An immortalised rat brain endothelial cell line (GPNT) was used to investigate the mechanisms underlying dexamethasone-induced decrease in paracellular perme...

journal_title：Neuroscience letters

authors： Romero IA,Radewicz K,Jubin E,Michel CC,Greenwood J,Couraud PO,Adamson P

更新日期：2003-06-26 00:00:00

abstract：:Parkinson's disease (PD) is the second most frequent neurodegenerative disorder. It is characterized by selective degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Early-onset familial forms of PD are associated with mutations in several genes, including parkin, pink1 and dj-1. DJ-1 en...

journal_title：Neuroscience letters

authors： Jaramillo-Gómez J,Niño A,Arboleda H,Arboleda G

更新日期：2015-08-31 00:00:00

abstract：:Galectin-3 is a β-galactosidase-binding lectin which is important in cell proliferation and apoptotic regulation. Encephalomyocarditis virus (EMCV), which includes the Enterovirus genus, can cause not only acute myocarditis but also neuronal degeneration of central nervous system in various animals including mice. The...

journal_title：Neuroscience letters

authors： Kobayashi K,Niwa M,Hoshi M,Saito K,Hisamatsu K,Hatano Y,Tomita H,Miyazaki T,Hara A

更新日期：2015-04-10 00:00:00

abstract：:Somatostatin (SRIF) release from fetal rat cortical cells was stimulated by exposure to 10(-5) M N-methyl-D-aspartate (NMDA) (250 +/- 20% of basal at 96 h). A similar but much less potent effect was seen with kainate (KA) but not with quisqualate (Q) which inhibited SRIF release (KA 150 +/- 13%, Q 65 +/- 18% of basal ...

journal_title：Neuroscience letters

authors： Ham J,Rickards C,Scanlon M

更新日期：1991-08-19 00:00:00

abstract：:The contribution of the circadian pacemaker and the sleep homeostat to sleep tendency and consolidation was quantified by forced desynchrony of the sleep-wake cycle from the circadian pacemaker in eight men who lived in time-isolation for 33-36 days. Analysis of 175 polygraphically recorded sleep episodes revealed tha...

journal_title：Neuroscience letters

authors： Dijk DJ,Czeisler CA

更新日期：1994-01-17 00:00:00

abstract：:We describe a new model of neurogenic pulmonary edema in spinal cord injured Wistar male rats. The pulmonary edema was elicited by an epidural thoracic balloon compression spinal cord lesion, performed under a low concentration of isoflurane (1.5 or 2%) in air. Anesthesia with 1.5% isoflurane promoted very severe inte...

journal_title：Neuroscience letters

authors： Sedý J,Urdzíková L,Likavcanová K,Hejcl A,Jendelová P,Syková E

更新日期：2007-08-16 00:00:00

abstract：:Effects of intracellularly applied L-arginine and nicotinamide adenine dinucleotide phosphate (NADPH) on the dark voltage and light responses of retinal rods were studied by means of the whole-cell patch-clamp technique. In this mode an exchange of substances by diffusion between cytosol and pipette medium occurs (Pfl...

journal_title：Neuroscience letters

authors： Tsuyama Y,Nöll GN,Schmidt KF

更新日期：1993-01-04 00:00:00

abstract：:It is well-known that cocaine dependence is a public health issue, and several studies stress the need to look for new and more effective treatments. Although the mesolimbic dopamine (DA) system, which originates in the ventral tegmental area (VTA) and projects to several forebrain structures, is known to be criticall...

journal_title：Neuroscience letters

authors： Zacarias MS,Ramos AC,Alves DR,Galduróz JC

更新日期：2012-04-04 00:00:00

abstract：:We performed an electron microscopic study in layers II-III of S-1 in rats, using postembedding immunogold histochemistry to compare the synaptic distribution of N-methyl D-aspartate (NMDA) receptors (assessed with an antibody for the NMDAR1 subunit) with that of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (A...

journal_title：Neuroscience letters

authors： Kharazia VN,Weinberg RJ

更新日期：1997-11-28 00:00:00

abstract：:Diabetic polyneuropathy is a common and disturbing complication of diabetes mellitus, presenting patients and caregivers with a substantial disease burden. Emerging mechanisms which are underlying diabetes may provide novel pathways to understand diabetic polyneuropathy (DPN). Specifically, non-coding RNA molecules co...

journal_title：Neuroscience letters

authors： Meydan C,Üçeyler N,Soreq H

更新日期：2020-07-13 00:00:00

abstract：:Ibotenate induced a concentration- and largely calcium-dependent release of endogenous glutamate from guinea pig cerebro-cortical synaptosomes. In the absence of Mg2+, the response to ibotenate was enhanced through a mechanism involving N-methyl-D-aspartate (NMDA) receptors; this component was sensitive to the NMDA an...

journal_title：Neuroscience letters

authors： Jones PG,Roberts PJ

更新日期：1990-03-26 00:00:00

abstract：:Pharmacological blocking agents were used to assess the contributions of different K(+)-currents to spike-repolarization and early spike-afterhyperpolarization recorded in dissociated, tissue-cultured rat superior cervical sympathetic neurones using both patch-clamp and impalement microelectrode techniques. Effects of...

journal_title：Neuroscience letters

authors： Marsh SJ,Brown DA

更新日期：1991-12-09 00:00:00

abstract：:Magnetic resonance imaging was used to investigate the relation between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and volumetric measurements for the medial temporal lobe structures (amygdala, hippocampus, and parahippocampal gyrus) and prefrontal sub-regions (the superior frontal gyrus, middl...

journal_title：Neuroscience letters

authors： Takahashi T,Suzuki M,Tsunoda M,Kawamura Y,Takahashi N,Tsuneki H,Kawasaki Y,Zhou SY,Kobayashi S,Sasaoka T,Seto H,Kurachi M,Ozaki N

更新日期：2008-04-11 00:00:00

abstract：:A fundamental question in human sexuality regards the neural substrate underlying sexually-arousing representations. Lesion and neuroimaging studies suggest that dorsolateral pre-frontal cortex (DLPFC) plays an important role in regulating the processing of visual sexual stimulation. The aim of this Functional Near-In...

journal_title：Neuroscience letters

authors： Leon-Carrion J,Martín-Rodríguez JF,Damas-López J,Pourrezai K,Izzetoglu K,Barroso Y Martin JM,Dominguez-Morales MR

更新日期：2007-04-06 00:00:00

abstract：:The cerebellum was recently proposed to play a role in cognition and sensation in addition to motor phenomena. We have shown that the cerebellum is involved in the processing of sensory nociceptive information. In this study, the activity of neurons in the dorsal column nuclei (DCN) was tested following stimulation in...

journal_title：Neuroscience letters

authors： Saab CY,Garcia-Nicas E,Willis WD

更新日期：2002-07-12 00:00:00

abstract：:Elevated introcular pressure (IOP)-induced retinal neuron ischemic death includes an early phase of necrosis and prolonged phase of apoptosis. We used this ischemic model to observe the changes of sortilin and p75(NTR) protein expressions in rat retina. The results of Western blot analysis showed the expression of p75...

journal_title：Neuroscience letters

authors： Wei Y,Wang N,Lu Q,Zhang N,Zheng D,Li J

更新日期：2007-12-18 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNAs that function as tumor suppressors or oncogenes. MicroRNA-107 (miR-107), a transcriptional target of p53, is deregulated in many cancer cell lines. Here, we showed that miR-107 is down-regulated in glioma tissues and cell lines, in particular, p53-mutated U251 and A172. Tran...

journal_title：Neuroscience letters

authors： Chen L,Zhang R,Li P,Liu Y,Qin K,Fa ZQ,Liu YJ,Ke YQ,Jiang XD

更新日期：2013-02-08 00:00:00

abstract：:Several lines of evidence suggest a physiological role for Cu2+ in regulating nervous system function. In the present study using whole-cell patch-clamp recording, Cu2+ greatly enhanced current activated by 10 microM ATP in the majority of rat nodose ganglion neurons. The enhancement was concentration-dependent betwee...

journal_title：Neuroscience letters

authors： Li C,Peoples RW,Weight FF

更新日期：1996-11-15 00:00:00

abstract：:Children and adolescents with Autism Spectrum Disorder (ASD) are characterized by an impaired Theory of Mind (ToM). Recent evidence suggested that two aspects of ToM (cognitive ToM versus affective ToM) are differentially impaired in individuals with ASD. In this study, we examined the neural correlates of cognitive a...

journal_title：Neuroscience letters

authors： Kim E,Kyeong S,Cheon KA,Park B,Oh MK,Chun JW,Park HJ,Kim JJ,Song DH

更新日期：2016-05-16 00:00:00

abstract：:The occurrence and distribution of nociceptin, a 17-amino acid peptide with structural similarity to dynorphin A, and its receptor, opioid receptor-like-1 (ORL1) receptor, were investigated in the guinea-pig sympathetic nervous system by means of immunohistochemistry and reverse transcription-polymerase chain reaction...

journal_title：Neuroscience letters

authors： Kummer W,Fischer A

更新日期：1997-09-26 00:00:00

abstract：:We raised polyclonal antibodies against the C-terminal peptides of protein kinase C (PkC) subspecies alpha, beta 1, beta 2, gamma, delta, epsilon, and zeta and checked their specificity against brain extracts using Western immunoblot analysis. With equal amounts of protein applied to gels PkC subspecies beta 1, delta,...

journal_title：Neuroscience letters

authors： Gott AL,Mallon BS,Paton A,Groome N,Rumsby MG

更新日期：1994-04-25 00:00:00

abstract：:Four weeks after lesion of the cortico-striatal pathway, the specific kainic acid binding was reduced by 20% in the neostriatum. It is concluded that the binding sites are most likely not located on cortico-striatal neurons. The displacement of kainic acid by some chemical indicates that the kainic acid binding site i...

journal_title：Neuroscience letters

authors： Henke H,Cuénod M

更新日期：1979-03-01 00:00:00

abstract：:Low doses of colchicine (greater than 0.5 microgram) injected into the eyes of young chickens irreversibly inhibit axonal transport of material labelled with [3H]fucose. This is due to almost total destruction of the retinal ganglion cells, while other retinal cell types, including the displaced amacrine cells found i...

journal_title：Neuroscience letters

authors： Morgan IG

更新日期：1981-07-17 00:00:00

abstract：:The availability of choline during the prenatal period influences neural and cognitive development. Here we report that choline supplementation during a six-day gestational period protects against neurodegeneration in the posterior cingulate and retrosplenial cortices of adult female rats produced by systemic administ...

journal_title：Neuroscience letters

authors： Guo-Ross SX,Jones KH,Shetty AK,Wilson WA,Swartzwelder HS

更新日期：2003-05-01 00:00:00

abstract：:Application of NMDA, or agents releasing nitric oxide (NO), onto the dendrites of hippocampal granule cells increased the levels of the mRNA encoding MAP2, a cytoskeletal component induced during periods of neurite outgrowth. Furthermore, local increases in the hybridisation signal in the molecular layer, representing...

journal_title：Neuroscience letters

authors： Johnston HM,Morris BJ

更新日期：1994-08-15 00:00:00

abstract：:We raised polyclonal antibodies against a gene product responsible for late infantile neuronal ceroid lipofuscinosis (CLN2). By Western blotting, all three antisera recognized the CLN2 protein at approximately 49 kDa in human brain homogenates. Immunohistochemistry using the antisera demonstrated the granular labellin...

journal_title：Neuroscience letters

authors： Oka A,Kurachi Y,Mizuguchi M,Hayashi M,Takashima S

更新日期：1998-11-27 00:00:00