The nicotinic alpha subunit MARA1 is necessary for cholinergic evoked calcium transients in Manduca neurons.

abstract：:Adult filum terminale (FT) is an atypical region from where multipotent neural progenitor cells (NPCs) have been isolated. However, poor neuronal differentiation rate of FT-NPCs currently limits their clinical applications. Using custom-designed electric fields (EFs), this study sets up a method to significantly impro...

journal_title：Neuroscience letters

authors： Dong ZY,Pei Z,Li Z,Wang YL,Khan A,Meng XT

更新日期：2017-06-09 00:00:00

abstract：:Hexokinase is known as the first enzyme and rate-limiting step in glycolysis. The role of hexokinase activity and localization in regulating the rate of axonal regeneration was studied in cultured adult sensory neurons of dorsal root ganglia (DRG). Immunofluorescent staining of DRG demonstrated that small-medium neuro...

journal_title：Neuroscience letters

authors： Wang Z,Gardiner NJ,Fernyhough P

更新日期：2008-03-21 00:00:00

abstract：:In ten patients with Parkinson's disease (PD) and ten age-matched healthy controls, we applied 15 30-s trains of subthreshold 5-Hz repetitive transcranial magnetic stimulation (rTMS) over the primary motor hand area. Ten minutes after rTMS, PD patients showed a significant prolongation of the transcranially evoked sil...

journal_title：Neuroscience letters

authors： Siebner HR,Mentschel C,Auer C,Lehner C,Conrad B

更新日期：2000-04-28 00:00:00

abstract：:Using a reproducible two-vessel occlusion model for forebrain ischemia in rats, we investigated the temporal and spatial changes of vascular endothelial growth factor (VEGF) expression after transient forebrain ischemia with Northern blot analysis and in situ hybridization. Northern blot analysis revealed that VEGF mR...

journal_title：Neuroscience letters

authors： Lee MY,Ju WK,Cha JH,Son BC,Chun MH,Kang JK,Park CK

更新日期：1999-04-16 00:00:00

abstract：:Incubation of C6 astrocytoma cells with bacterial endotoxin (lipopolysaccharide; LPS) plus interferon-gamma (IFN-gamma), or with a combination of cytokines (TNF-alpha, IL1-beta, and IFN-gamma) leads to high levels of inducible nitric oxide synthase (iNOS) expression. Previous results demonstrated a requirement for tyr...

journal_title：Neuroscience letters

authors： Galea E,Reddi J,Feinstein DL

更新日期：1995-11-24 00:00:00

abstract：:Fragile X syndrome (FXS), a disorder caused by a mutation in the FMR1 gene, is often associated with Attention Deficit Hyperactivity Disorder (ADHD). Common treatments for the hyperactivity often seen in ADHD involve the use of stimulants and α2-adrenergic agonists. The Fmr1 knockout (KO) mouse has been found to be a ...

journal_title：Neuroscience letters

authors： Wrenn CC,Heitzer AM,Roth AK,Nawrocki L,Valdovinos MG

更新日期：2015-01-12 00:00:00

abstract：:Functional recovery after experimental stroke in rats is enhanced by environmental enrichment by stimulating plastic changes in brain regions outside the lesion, but the molecular mechanisms are not known. We investigated the effect of environmental enrichment after focal cerebral ischemia on cognitive recovery and hi...

journal_title：Neuroscience letters

authors： Rönnbäck A,Dahlqvist P,Svensson PA,Jernås M,Carlsson B,Carlsson LM,Olsson T

更新日期：2005-09-09 00:00:00

abstract：:It has been known that ethanol causes neuronal cell death through oxidative stress. Ethanol itself and reactive oxygen species (ROS) produced by ethanol modulate intracellular signaling pathways including mitogen-activated protein kinase (MAPK) cascades. This study was conducted to examine the impact of ethanol on MAP...

journal_title：Neuroscience letters

authors： Ku BM,Lee YK,Jeong JY,Mun J,Han JY,Roh GS,Kim HJ,Cho GJ,Choi WS,Yi GS,Kang SS

更新日期：2007-05-23 00:00:00

abstract：:With the use of an antiserum against human apelin-36, apelin-immunoreactivity (irAP) was detected in neurons and cell processes of the supraoptic nucleus (SO), paraventricular nucleus (PVH), accessory neurosecretory nuclei (Acc) and suprachiasmatic nucleus. Strongly labeled cells/processes were noted in the internal l...

journal_title：Neuroscience letters

authors： Brailoiu GC,Dun SL,Yang J,Ohsawa M,Chang JK,Dun NJ

更新日期：2002-07-26 00:00:00

abstract：:We investigated the cortico-muscular coherence in a patient with posturally induced cortically originating negative myoclonus. We recorded simultaneously 50 channels EEG and EMG from quadriceps and biceps femoris muscles of the left upper leg. Three experimental conditions were investigated with the patient in a seate...

journal_title：Neuroscience letters

authors： Kristeva R,Popa T,Chakarov V,Hummel S

更新日期：2004-08-19 00:00:00

abstract：:The anatomical distribution of insulin-degrading enzyme (IDE) was studied in normal and Alzheimer's disease (AD) human brains. By use of a monospecific, polyclonal antiserum against the enzyme we identified IDE antigen in multiple cortical and subcortical neurons. Glia did not show IDE immunoreactivity. In AD brains i...

journal_title：Neuroscience letters

authors： Bernstein HG,Ansorge S,Riederer P,Reiser M,Frölich L,Bogerts B

更新日期：1999-03-26 00:00:00

abstract：:The mammalian circadian system contains both central and peripheral oscillators. It was reported that the rhythmic expressions of period homolog 2 (per2) mRNA in peripheral tissues were abolished by the suprachiasmatic nucleus (SCN) lesions. However, there are no reports that ventromedial hypothalamic (VMH) lesions ca...

journal_title：Neuroscience letters

authors： Kiba T,Kintaka Y,Suzuki Y,Ishizuka N,Ishigaki Y,Inoue S

更新日期：2010-03-08 00:00:00

abstract：:Transforming growth factor-β (TGF-β) is an anti-inflammatory cytokine and is expressed in the injured spinal cord. TGF-β signals through receptors to activate Smad proteins, which translocate into the nucleus. In the present study, we investigated the chronological alterations and cellular locations of the TGF-β/Smad ...

journal_title：Neuroscience letters

authors： Joko M,Osuka K,Usuda N,Atsuzawa K,Aoyama M,Takayasu M

更新日期：2013-08-09 00:00:00

abstract：:A retrograde tracer, Diamidino yellow, was injected into the hindlimb region of the supplementary motor area after intracortical microstimulation mapping in the Japanese monkey. As a result, a cluster of retrogradely labeled neurons was found in the caudal bank of the arcuate sulcus, which corresponds to the ventral p...

journal_title：Neuroscience letters

authors： Tokuno H,Inase M

更新日期：1994-04-25 00:00:00

abstract：:The excitotoxic cell death and the release of gamma-amino-butyric acid (GABA) evoked by excitatory amino acids (EAAs) were comparatively examined in rat cortical sister cultures grown in serum-free (N2) and serum-supplemented (SSM) media. Cell death was induced by 24 h exposure to 1 mM N-methyl-D-aspartate (NMDA), alp...

journal_title：Neuroscience letters

authors： Erdö SL,Cai N,Lakics V

更新日期：1993-04-02 00:00:00

abstract：:Histone modifications, such as lysine methylation, acetylation and ubiquitination, are epigenetic tags that shape the chromatin landscape and regulate transcription required for synaptic plasticity and memory. Here, we show that transcription-promoting histone H3 trimethylated at lysine 4 (H3K4me3), histone H3 acetyla...

journal_title：Neuroscience letters

authors： Bach SV,Tacon PR,Morgan JW,Hegde AN

更新日期：2015-03-30 00:00:00

abstract：:Resting-state functional magnetic resonance imaging has confirmed that the strengths of the long distance functional connectivity between different brain areas are correlated with individual differences in intelligence. However, the association between the local connectivity within a specific brain region and intellig...

journal_title：Neuroscience letters

authors： Wang L,Song M,Jiang T,Zhang Y,Yu C

更新日期：2011-01-25 00:00:00

abstract：:We have investigated the presence of mutations in the parkin gene in patients with early-onset parkinsonism. Direct sequencing of the polymerase chain reaction (PCR) products showed a homozygous G deletion in the exon 7 (c.871delG) in one patient. This was a 38-year-old Moroccan woman with a history of parkinsonism of...

journal_title：Neuroscience letters

authors： Muñoz E,Pastor P,Martí MJ,Oliva R,Tolosa E

更新日期：2000-07-28 00:00:00

abstract：:Employing video-enhanced contrast (VEC) microscopy, we examined whether TAK-029 (GPIIb/IIIa antagonist) inhibits the adhesion of activated platelets to human brain microvascular endothelial cells (HBEC) in vitro. HBECs were cultured on a coverglass and put in the observation chamber of VEC microscopy. Then, activated ...

journal_title：Neuroscience letters

authors： Tanahashi N,Fukuuchi Y,Tomita M,Tomita Y,Inoue K,Satoh H,Abe T

更新日期：2001-03-23 00:00:00

abstract：:The effects of systemic hypothermia (33.5 degrees C) on the ischemia-evoked release of the neurotransmitter amino acids, glutamate, aspartate, gamma-amino-butyric acid (GABA) and glycine into rat cerebral cortical superfusates were evaluated in the rat four vessel occlusion model. Glutamate, aspartate and GABA, but no...

journal_title：Neuroscience letters

authors： Simpson RE,Walter GA,Phillis JW

更新日期：1991-03-11 00:00:00

abstract：:Restoration of cellular microenvironment is important in the treatment of neurodegenerative diseases for optimal functioning and survival of neurons. Oxidative stress has been proposed as one of the major pathogenic drivers in Parkinson's disease. Parkinson's model was developed by chronic administration of a pesticid...

journal_title：Neuroscience letters

authors： Bandookwala M,Sahu AK,Thakkar D,Sharma M,Khairnar A,Sengupta P

更新日期：2019-10-15 00:00:00

abstract：:Gastrin-releasing peptide (GRP) was demonstrated by immunohistochemistry and high-performance liquid chromatography to be present in the great majority of neurons in the geniculate ganglion of rat and man. This was in contrast to findings in the sphenopalatine ganglion of rat, where only little GRP was found, and in t...

journal_title：Neuroscience letters

authors： Hardebo JE,Suzuki N,Ekman R

更新日期：1992-05-25 00:00:00

abstract：:Dysbindin gene (DTNBP1) has been associated with schizophrenia, but literature findings are inconsistent, and further analyses are required. This study is aimed to investigate if a set of DTNBP1 variations might influence clinic psychotic phenotype or treatment response in a sample of 240 Korean schizophrenic in-patie...

journal_title：Neuroscience letters

authors： Pae CU,Drago A,Kim JJ,Patkar AA,Jun TY,Lee C,Mandelli L,De Ronchi D,Paik IH,Serretti A

更新日期：2008-08-01 00:00:00

abstract：:Segments of the mouse sciatic nerve were preloaded with either d-2,3-(3)H-Aspartic acid [nonmetabolizable analog of glutamate] or l-(14)C-proline and the release of these exogenous molecules was evaluated in the fractions of the perfusate following electrical or magnetic stimulation. The electrical stimulation (10Hz, ...

journal_title：Neuroscience letters

authors： Wieraszko A,Ahmed Z

更新日期：2009-07-10 00:00:00

abstract：:The intra-adrenal distribution of nitric oxide synthase (NOS)-immunoreactive nerve fibres was studied in rats subjected to various denervations. Splanchnic nerve section eliminated the NOS-immunoreactive nerve fibres which innervate adrenal chromaffin and neuronal cells. It did not affect those innervating blood vesse...

journal_title：Neuroscience letters

authors： Afework M,Ralevic V,Burnstock G

更新日期：1995-05-05 00:00:00

abstract：:In CA3 pyramidal neurons of guinea pig hippocampal slices an outward current activated by the GABAB agonist, baclofen (0.3 microM, Ibac) was reduced by low concentrations of carbachol (Cch, 0.1-0.3 microM). The effect of Cch desensitized suggesting that the receptor subtype involved in this muscarinic effect of Cch wa...

journal_title：Neuroscience letters

authors： Müller W,Brunner H,Misgeld U

更新日期：1989-05-22 00:00:00

abstract：:This experiment examined the hypothesis that aging reduces the coupling between system components, resulting in a loss of complexity in behavior. Young (18-23 years), old (60-65 years), and older old (70-75 years) subjects performed rhythmical movement and postural tasks with the index finger. Irregularity of the acce...

journal_title：Neuroscience letters

authors： Hong SL,James EG,Newell KM

更新日期：2008-03-12 00:00:00

abstract：:The effects of electrical stimulation of the central (CE) and basolateral (BL) amygdaloid nuclei on pancreatic exocrine secretion were tested in urethane-anesthetized rats. Electrical stimulation (0.1 mA, 1 ms, 40 Hz) of the CE significantly increased basal and hormone (secretin+cholecystokinin-8)-infused pancreatic e...

journal_title：Neuroscience letters

authors： Hahn SJ,Yoon SH,Sim SS,Rhie DJ,Jo YH,Kim MS

更新日期：1994-03-14 00:00:00

abstract：:Chronic increases in spontaneous multiunit activity can be induced in the dorsal cochlear nucleus (DCN) of hamsters by intense sound exposure (Kaltenbach and McCaslin, 1996). It has been hypothesized that this hyperactivity may represent a neural code that could underlie the sound percepts of tinnitus. The goal of the...

journal_title：Neuroscience letters

authors： Kaltenbach JA,Zacharek MA,Zhang J,Frederick S

更新日期：2004-01-23 00:00:00

abstract：:It is well known that spinal glia plays a key role in the pathogenesis of pain. The present study was designed to determine the roles of spinal microglia in bee venom-induced persistent spontaneous nociception (PSN), mechanical hyperalgesia and inflammation. We determined the effects of microglia inhibitor minocycline...

journal_title：Neuroscience letters

authors： Chen HS,Wang JX,Zhang JH,Li FP,Qu F,Liu BJ,Li M,Lu Y

更新日期：2013-02-08 00:00:00