Abstract:
:The effect of apamin on learning was examined using two behavioral tasks where the animals were subjected to two trials separated by a 24h interval. In the Y maze task, apamin administered before the acquisition session did not enhance performance on both the acquisition session and the restitution session. In the second behavioral task, animals were trained to press a lever to obtain a food pellet (fixed ratio 1). Then, to study the effect of apamin on extinction, animals were submitted to two sessions where a press on the lever was not reinforced. Apamin administered before the acquisition session reduced the number of lever presses during the first 3-min period of the restitution session. These results suggest that the blockade of SK channels could improve the acquisition but not when the task requires the processing of spatial information.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Deschaux O,Bizot JCdoi
10.1016/j.neulet.2005.05.050keywords:
subject
Has Abstractpub_date
2005-09-23 00:00:00pages
5-8issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(05)00618-Xjournal_volume
386pub_type
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