当前位置： SCI文献检索 > NEUROSCIENCE LETTERS期刊下所有文献 > The therapeutic potential of Berberine chloride hydrate against harmaline-induced motor impairments in a rat model of tremor.

The therapeutic potential of Berberine chloride hydrate against harmaline-induced motor impairments in a rat model of tremor.

Abstract：

:Essential tremor (ET) is a progressive neurological disorder with motor and non-motor symptoms. It has conclusively been shown that modulation of glutamate receptors could ameliorate ET. Recent studies have suggested that Berberine (BBR) has an inhibitory effect on glutamate receptors. Therefore, BBR may have therapeutic effects on ET. In this study, male Wistar rats (n=10 in each group) weighing 40-60 g were divided into control, harmaline (30 mg/kg, i.p.) and berberine (10, 20 or 50mg/kg, i.p, 15 min before harmaline injection) groups. Open field, rotarod, wire grip and foot print tests were used to evaluate motor performance. The results indicated that the administration of BBR (10 and 20mg/kg) attenuated harmaline-induced tremor in rats, but the beneficial effects of BBR could not be identified at dose 50mg/kg. In addition, BBR ameliorated gait disturbance in doses of 10 and 20mg/kg. The high dose of BBR not only failed to recover step width but also showed an adverse effect on left and right step length. The results indicate that BBR only in dose of 20mg/kg recovers mobility duration. The current study found a dose-dependent manner for the therapeutic effects of BBR in ET. Our study provides the initial evidence for the effects of BBR on motor function. Since BBR exerts its effects mainly through regulation of neurotransmitter release or blocke of NMDA receptors, thus, it is predicted that BBR ameliorate harmaline effect through blockade of NMDA receptors or glutamate release. This is an important issue for future research to evaluate the possible mechanisms involved.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Vaziri Z,Abbassian H,Sheibani V,Haghani M,Nazeri M,Aghaei I,Shabani M

doi

10.1016/j.neulet.2015.01.078

subject

Has Abstract

pub_date

2015-03-17 00:00:00

pages

84-90

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(15)00091-9

journal_volume

590

pub_type

杂志文章

相关文献

NEUROSCIENCE LETTERS文献大全
  • Possible roles of Plexin-A4 in positioning of oligodendrocyte precursor cells in developing cerebral cortex.

    abstract：:Molecular mechanisms regulating positions of oligodendrocyte precursor cells (OPCs) remain unclear in developing cerebral cortex. To explore the mechanisms, we investigated how Plexin-A4, receptor of Semaphorin in OPCs, is involved in the positioning. We found that Plexin-A4 knockout mice exhibited (1) an increased nu...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2012.04.005

    authors： Okada A,Tomooka Y

    更新日期：2012-05-16 00:00:00

  • Postnatal ontogeny of the rat brain neurotensin receptor mRNA.

    abstract：:Total RNA was purified from rat forebrain at different postnatal ages and analyzed by Northern blot using a specific neurotensin receptor RNA probe. The rat neurotensin receptor mRNA was present in high amount during the first 10 days of life. Thereafter, it rapidly decreased and was undetected after 20 days. [3H]neur...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(93)90639-3

    authors： Hermans E,Jeanjean AP,Laduron PM,Octave JN,Maloteaux JM

    更新日期：1993-07-09 00:00:00

  • Toward the development of a sensitive, pre-clinical screen for neurological diseases from spontaneous neural coordination in juvenile and young-adult C57BK6 mice.

    abstract：:Spontaneous Frequency Bursts (SFBs) are a newly discovered form of long-distance neural coordination. They have several distinctive properties, including near-simultaneity of occurrence (+/-25-50 ms) across distant brain regions and high within- and across-site coherence in multiple low and high frequency bands, presu...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2010.01.014

    authors： Robson J,Mehta N,Polcz JE,Hermer L

    更新日期：2010-03-03 00:00:00

  • Non-conscious neural regulation against mortality concerns.

    abstract：:Social psychological studies have shown that an experience of threat such as an encounter with death-related stimuli and social exclusion results in tuning toward positive emotional information. Neuroimaging studies have also begun to uncover the neural basis of threat coping, and in this literature, the activity of t...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2013.07.027

    authors： Yanagisawa K,Kashima ES,Moriya H,Masui K,Furutani K,Nomura M,Yoshida H,Ura M

    更新日期：2013-09-27 00:00:00

  • Specialization in pyramidal cell structure in the cingulate cortex of the Chacma baboon (Papio ursinus): an intracellular injection study of the posterior and anterior cingulate gyrus with comparative notes on the macaque and vervet monkeys.

    abstract：:This study forms part of an ongoing investigation of pyramidal cell structure in the cingulate cortex of primates. Recently we have demonstrated that layer III pyramidal cells in the anterior cingulate gyrus are considerably larger, more branched and more spinous than those in the posterior cingulate gyrus (areas 24 a...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2005.06.010

    authors： Elston GN,Benavides-Piccione R,Elston A,DeFelipe J,Manger P

    更新日期：2005-10-28 00:00:00

  • Garcinone B reduces prostaglandin E2 release and NF-kappaB-mediated transcription in C6 rat glioma cells.

    abstract：:In the course of our survey of natural compounds inhibiting prostaglandin E2 release and/or lipopolysaccharide (LPS)-induced transcriptional stimulation via NF-kappaB, a central regulator of inflammatory genes, from natural resources, we found garcinone B, a xanthone from callus tissue culture of Hypericum patulum, as...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2005.10.023

    authors： Yamakuni T,Aoki K,Nakatani K,Kondo N,Oku H,Ishiguro K,Ohizumi Y

    更新日期：2006-02-20 00:00:00

  • Long-term exposure to high glucose increases the content of several exocytotic proteins and of vesicular GABA transporter in cultured retinal neural cells.

    abstract：:Diabetic retinopathy is a leading cause of vision loss and blindness. Increasing evidence has shown that the neuronal components of the retina are affected even before the detection of vascular lesions. Hyperglycemia is considered the main pathogenic factor for the development of diabetic complications. Nevertheless, ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2015.06.044

    authors： Baptista FI,Castilho ÁF,Gaspar JM,Liberal JT,Aveleira CA,Ambrósio AF

    更新日期：2015-08-18 00:00:00

  • Hydroxy-safflor yellow A inhibits neuroinflammation mediated by Aβ₁₋₄₂ in BV-2 cells.

    abstract：:Inflammation is an important contributor to the development of Alzheimer's disease (AD). Anti-inflammatory medication may offer promising treatment for AD. Hydroxy-safflor yellow A (HSYA), a chemical component of the safflower yellow pigments, has been reported to exert potent immunosuppressive effects. This study exa...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2014.01.005

    authors： Zhang Z,Wu Z,Zhu X,Hui X,Pan J,Xu Y

    更新日期：2014-03-06 00:00:00

  • Dorsal raphé nucleus glucocorticoid receptors inhibit tph2 gene expression in male C57BL/6J mice.

    abstract：:The serotonergic dorsal raphé nucleus (DRN) expresses glucocorticoid receptors (GR), and systemic glucocorticoids have been shown to regulate expression and activity of tryptophan hydroxylase isoform 2, the rate-limiting enzyme for serotonin synthesis in brain. We have used intra-DRN injection of pseudotyped adeno-ass...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2017.11.041

    authors： Vincent MY,Donner NC,Smith DG,Lowry CA,Jacobson L

    更新日期：2018-02-05 00:00:00

  • The anticonvulsant effects of allopregnanolone against amygdala-kindled seizures in female rats.

    abstract：:It has long been known that the steroid hormone progesterone has anticonvulsant actions. These have been documented both in animals and humans. In 2003, we reported that progesterone's first metabolite, 5alpha-dihydroprogesterone (5alpha-DHP), has strong anticonvulsant effects in amygdala-kindled female rats. These oc...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2006.10.023

    authors： Lonsdale D,Burnham WM

    更新日期：2007-01-10 00:00:00

  • Effects of local anesthetics on opioid inhibition of calcium current in rat dorsal root ganglion neurons.

    abstract：:Neuraxial analgesia is often provided using a mixture of local anesthetics and opioids. This combination of agents provides better pain relief and is generally associated with fewer side effects than when either drug is given alone. Local anesthetics have been shown to alter signaling of other G protein-coupled recept...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2007.03.041

    authors： Komai H,McDowell TS

    更新日期：2007-05-18 00:00:00

  • A substance P mediated pathway contributes to 6-hydroxydopamine induced cell death.

    abstract：:The neurotoxin 6-hydroxydopamine (6-OHDA) is used to induce dopaminergic cell death, resulting in insufficient striatal dopamine content in the basal ganglia and motor dysfunction typical of Parkinson's disease. Dopamine induces release of the neuropeptide substance P (SP) within the substantia nigra, whereas SP is ab...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2010.06.057

    authors： Thornton E,Tran TT,Vink R

    更新日期：2010-08-30 00:00:00

  • Adhesion of adenosine diphosphate-activated platelets to human brain microvascular endothelial cells under flow in vitro is mediated via GPIIb/IIIa.

    abstract：:Employing video-enhanced contrast (VEC) microscopy, we examined whether TAK-029 (GPIIb/IIIa antagonist) inhibits the adhesion of activated platelets to human brain microvascular endothelial cells (HBEC) in vitro. HBECs were cultured on a coverglass and put in the observation chamber of VEC microscopy. Then, activated ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(01)01608-1

    authors： Tanahashi N,Fukuuchi Y,Tomita M,Tomita Y,Inoue K,Satoh H,Abe T

    更新日期：2001-03-23 00:00:00

  • The effect of epigallocatechin gallate on suppressing disease progression of ALS model mice.

    abstract：:Epigallocatechin gallate (EGCG) is a constituent of green tea, and increasing evidence suggests that EGCG has neuroprotective effects on oxidative stress-injured neuronal cells, especially motoneurons. Although the neuroprotective effects of EGCG have been demonstrated in Parkinson's and Alzheimer's diseases and ische...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2005.10.056

    authors： Koh SH,Lee SM,Kim HY,Lee KY,Lee YJ,Kim HT,Kim J,Kim MH,Hwang MS,Song C,Yang KW,Lee KW,Kim SH,Kim OH

    更新日期：2006-03-06 00:00:00

  • Oxidative stress and Parkinson's disease: conflict of oxidant-antioxidant systems.

    abstract：:Parkinson's disease (PD) is defined as a chronic neurodegenerative disorder which is diagnosed mostly by its clinical manifestations. Reactive oxygen species (ROS) are considered as key modulators in the development of PD. Despite the intensive investigations, antioxidant-dependent molecular mechanisms of initiation a...

    journal_title：Neuroscience letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.neulet.2019.134296

    authors： Hemmati-Dinarvand M,Saedi S,Valilo M,Kalantary-Charvadeh A,Alizadeh Sani M,Kargar R,Safari H,Samadi N

    更新日期：2019-09-14 00:00:00

  • Mode of action of a sympathomimetic amine, paramethoxyphenylethylamine (PMPEA) in the mouse CNS: Release of biogenic amines.

    abstract：:Paramethoxyphenylethylamine (PMPEA) is a sympathomimetic amine, like its parent compound, phenylethylamine. The intraperitoneal administration of PMPEA to mice produces a dose-dependent depletion of brain and heart norepinephrine, with significant reduction being observed one hour postinjection. At lower dosages, PMPE...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(75)90033-6

    authors： Ashkenazi R,Haber B

    更新日期：1975-09-01 00:00:00

  • Slow isomerization step in the interaction between mouse dopamine transporter and dopamine re-uptake inhibitor N-(3-iodoprop-2E-enyl)-2beta-carbo-[3H]methoxy-3beta-(4'-methylphenyl)nortropane.

    abstract：:The kinetics of the association and dissociation of the tritium-labeled selective and potent dopamine transporter inhibitor N-(3-iodoprop-2E-enyl)-2beta-carbo-[3H]methoxy-3beta-(4'-methylphenyl)nortropane ([3H]PE2I) with the transporter of mouse striatal membranes was studied. The analysis revealed that the specific b...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2006.10.007

    authors： Stepanov V,Järv J

    更新日期：2006-12-27 00:00:00

  • Adenosine induces apoptosis by inhibiting mRNA and protein synthesis in chick embryonic sympathetic neurons.

    abstract：:Our previous work has established that adenosine is toxic to chick embryonic sympathetic neurons and kills freshly plated neurons by a process of apoptosis. Although the exact mechanism remains unknown, we found that phosphorylation of adenosine was essential to the toxicity. Using markers for RNA ([3H]uridine) and pr...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(98)00369-3

    authors： Kulkarni JS,Przywara DA,Wakade TD,Wakade AR

    更新日期：1998-06-05 00:00:00

  • The posterior insular-opercular cortex: An access to the brain networks of thermosensory and nociceptive processes?

    abstract：:In spite of systematic investigations, the existence of a specific cortex that could encode for the intensities of somatosensory stimuli, including within nociceptive ranges, is still a matter of debate. The present consensus is that pain is expressed in a distributed network made of thalamus, SII, insula, ACC, and, l...

    journal_title：Neuroscience letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.neulet.2018.11.042

    authors： Peyron R,Fauchon C

    更新日期：2019-05-29 00:00:00

  • Tyrosine hydroxylase-immunoreactive neurons in the human cerebral cortex: a novel catecholaminergic group?

    abstract：:Tyrosine hydroxylase-like immunoreactive (TH-IR) neurons with morphological features of interneurons were found throughout the human cerebral cortex. Quantitative estimates in 14 different cytoarchitectonic areas revealed a specific regional distribution pattern, neurons being less dense in primary cortical areas and ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(87)90464-2

    authors： Gaspar P,Berger B,Febvret A,Vigny A,Krieger-Poulet M,Borri-Voltattorni C

    更新日期：1987-10-05 00:00:00

  • 14-3-3Zeta does not increase GSK3beta-mediated tau phosphorylation in cell culture models.

    abstract：:Tau is a neuronal microtubule-associated protein whose function is regulated by site-specific phosphorylation. One protein kinase that is likely to play an important role in regulating the phosphorylation state of tau in vivo is glycogen synthase kinase (GSK) 3beta. The activity of GSK3beta is regulated by specific pr...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2005.04.101

    authors： Matthews TA,Johnson GV

    更新日期：2005-08-26 00:00:00

  • A20 protects neuronal apoptosis stimulated by lipopolysaccharide-induced microglial exosomes.

    abstract：:LPS-induced microglial activation has a major influence on neuronal damage in the inflammatory process. Integral to this is the cellular and molecular interaction between microglia and neurons. Exosomes, a mediator of communication between cells, can transfer lipids, proteins and nucleic acids, affecting many donor an...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2019.134480

    authors： Chen X,Qian B,Kong X,Hao J,Ye Y,Yang K,Xu T,Zhang F

    更新日期：2019-11-01 00:00:00

  • Male rats require testosterone to develop contralateral digastric muscle activity in response to noxious stimulation of the temporomandibular joint.

    abstract：:The influence of testosterone on the postnatal development of reflex electromyographic (EMG) jaw muscle activity evoked by injection of mustard oil (MO) into the temporomandibular joint region and the later recurrence of this EMG activity after intravenous injection of naloxone, was studied in male rats. MO-evoked EMG...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(02)01173-4

    authors： Seo K,Fujiwara N,Cairns BE,Someya G

    更新日期：2002-12-25 00:00:00

  • Hypoxia induces activation of a N-methyl-D-aspartate glutamate receptor-protein kinase C pathway in the dorsocaudal brainstem of the conscious rat.

    abstract：:To study in vivo phosphorylation of N-methyl-D-aspartate (NMDA) glutamate receptors and the recruitment of protein kinase C isoforms during acute hypoxia, dorsocaudal brainstem lysates were harvested from conscious rats exposed to either room air or hypoxia (10% O2 for 5 and 15 min). Increased phosphorylation of the N...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(99)00887-3

    authors： Simakajornboon N,Gozal E,Gozal YM,Gozal D

    更新日期：2000-01-07 00:00:00

  • Microtubular packing varies along the course of motor and sensory axons: possible regulation of microtubules by environmental cues.

    abstract：:In the toad Xenopus laevis, the microtubular density of 3-microns myelinated fibres was assessed in peripheral nerves, dorsal and ventral roots, and dorsal and ventral funiculi of the spinal cord. In the roots, the axonal microtubular density was 6 microtubules/microns 2 and twice as much at the other sampling sites. ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(89)90583-1

    authors： Saitua F,Alvarez J

    更新日期：1989-10-09 00:00:00

  • Functional coupling of human right and left cortical motor areas demonstrated with partial coherence analysis.

    abstract：:Although a linear correlation between oscillatory activities in the right and left motor cortices during movements has been shown in monkeys, there has been a debate whether scalp-recorded EEG coherence in human reflects a similar association. By applying partial coherence analysis, we demonstrated that interhemispher...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(00)01165-4

    authors： Mima T,Matsuoka T,Hallett M

    更新日期：2000-06-23 00:00:00

  • Noradrenaline depletion increases noradrenaline-induced antinociception in mice.

    abstract：:Mice were treated with N-2-chloroethyl-N-ethyl-2-bromobenzylamine hydrochloride (DSP4), which causes severe noradrenaline (NA) depletions in brain regions and the spinal cord, or vehicle i.p. They were tested 14 days later for antinociception induced by intrathecal injections of different doses of NA. A potentiation o...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(85)90222-8

    authors： Post C,Arweström E,Minor BG,Wikberg JE,Jonsson G,Archer T

    更新日期：1985-08-16 00:00:00

  • Involvement of rat lateral septum-acetylcholine pressor system in central amygdaloid nucleus-emotional pressor circuit.

    abstract：:There is an emotional pressor circuit composed of nuclei controlling emotion and stress, which may be the neurophysiological basis for prolonged emotional stress inducing hypertension. The central amygdaloid nucleus (AC) is the most important in this circuit, which widely connects with the other nuclei via its CRF (co...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(01)02531-9

    authors： Li YH,Ku YH

    更新日期：2002-04-19 00:00:00

  • Aripiprazole increases dopamine but not noradrenaline and serotonin levels in the mouse prefrontal cortex.

    abstract：:Aripiprazole, a novel atypical antipsychotic drug, can significantly increase dopamine (DA) levels in the prefrontal cortex of rats, but only at low doses below 1mg/kg. The aim of the present work was to test the effect of aripiprazole (0, 0.1, 0.3, 3 and 30 mg/kg, i.p.) on extracellular levels of monoamines in the pr...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2005.06.035

    authors： Zocchi A,Fabbri D,Heidbreder CA

    更新日期：2005-10-28 00:00:00

  • The time course of GABA action on the crayfish stretch receptor: evidence for a saturable GABA uptake.

    abstract：:The conductance increase induced by bath application of GABA has been measured in voltage-clamped stretch-receptor neurones of crayfish. A rapid conductance increase was obtained only at GABA concentrations above 3.3 X 10(-4) M. The response to lower GABA concentrations (between 10(-4) and 10(-6) M) developed slowly o...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(84)90521-4

    authors： Deisz RA,Dose M,Lux HD

    更新日期：1984-06-29 00:00:00