Abstract:
:We investigated microvascular damage in areas with magnetic resonance imaging (MRI)-defined apparent diffusion coefficient reduction (ADC-R) in a rat model of thromboembolic occlusion of the middle cerebral artery. Rats received either intracarotid recombinant tissue plasminogen activator (rt-PA) or saline. Microvascular basal lamina damage was quantified by immunohistochemical staining of collagen type IV and by videoimaging analysis. ADC-R positive basal ganglia (cortical) areas showed a significant reduction of stained microvascular area by 15+/-6% (8+/-7%) and the microvascular density by 13+/-5% (8+/-6%) of that on the non-ischemic control side (P<0.001). There were no significant microvascular differences between rats given rt-PA or saline, or between those with or without angiographically proven recanalization. This study reports for the first time that microvascular basal lamina damage in experimental thromboembolic stroke is confined to regions with ADC-R in MRI.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Vosko MR,Busch E,Burggraf D,Bültemeier G,Hamann GFdoi
10.1016/j.neulet.2003.09.050keywords:
subject
Has Abstractpub_date
2003-12-26 00:00:00pages
217-20issue
3eissn
0304-3940issn
1872-7972pii
S0304394003011418journal_volume
353pub_type
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