Abstract:
:Peripheral myelin P0 protein is a homophilic adhesion molecule of immunoglobulin superfamily to compact myelin structure. In addition to its roles in formation and maintenance of myelin, P0 shows neurite-outgrowth promotion activity of dorsal root ganglions. In this paper, we examined biological activity of P0 in central nervous system (CNS). Neurite outgrowth of cortical neurons of rat embryo was markedly promoted in the co-culture on C6 transformants expressing P0 protein. The neurite outgrowth was not inhibited by the P0-glycopeptide but specifically inhibited by the anti-P0 monoclonal antibody recognizing the extracellular peptide of P0. In in vivo studies, we observed significant axonal regeneration into grafts only in animals implanted with P0-expressing transformants after spinal one-third transection. These results suggest that P0 protein has promoting activity on the neurite elongation in CNS as well as in peripheral nervous system.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Yazaki T,Miura M,Asou H,Toya S,Uyemura Kdoi
10.1016/0304-3940(94)90859-1subject
Has Abstractpub_date
1994-07-18 00:00:00pages
13-6issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(94)90859-1journal_volume
176pub_type
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2004-11-23 00:00:00
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