The human superior cervical ganglion: neuropeptides and peptide receptors.

Abstract:

:Noradrenaline (NA)- and neuropeptide Y (NPY)-containing cell bodies were found to occur in high numbers (>75% of all cells were positive) in the human superior cervical ganglion and distributed homogeneously throughout the ganglion and showed colocalisation. A few cell bodies were VIP-immunoreactive (-ir) (less than 5%) but none of them showed NOS-, CGRP- or SP-ir. Receptor mRNA expression was studied with RT-PCR. Total RNA from the superior cervical ganglion was successfully extracted. By using appropriate sense and antisense oligonucleotides designed from the published human sequences, we could show the presence of mRNA for the human NPY Y1, NPY Y2 and VPAC1 receptors but not CGRP1 receptor mRNA.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Tajti J,Möller S,Uddman R,Bodi I,Edvinsson L

doi

10.1016/s0304-3940(99)00115-9

keywords:

subject

Has Abstract

pub_date

1999-03-26 00:00:00

pages

121-4

issue

2-3

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(99)00115-9

journal_volume

263

pub_type

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