Abstract：
:It is known that alcohol induces disorders in the metabolism of retinoids and particularly in the biosynthetic pathways of retinoic acid (RA). Since RA has, along with other hormones and particularly triiodothyronine (T3), a physiological role in the adult brain, the effect of chronic exposure to alcohol on RA and T3 status was investigated. The amounts of RA receptor (RAR) and T3 receptor (TR) mRNAs were quantified and the activity of the 'tissue' transglutaminase (tTG; an RA-dependent enzyme) was assayed in the brain of mice following chronic ethanol consumption (CEC; 12% v/v for 6-10 months). Compared to controls, ethanol-treated mice exhibited increased amounts of RAR and TR mRNAs together with an increase in tTG activity. It is hypothesized that the enhanced cellular action of RA and T3 could play a role in the previously described brain damages induced by CEC.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Alfos S,Higueret P,Pallet V,Higueret D,Garcin H,Jaffard Rdoi
10.1016/s0304-3940(96)12455-1subject
Has Abstractpub_date
1996-03-15 00:00:00pages
73-6issue
2-3eissn
0304-3940issn
1872-7972pii
S0304-3940(96)12455-1journal_volume
206pub_type
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