Intrathecal administration of the adenosine A1 receptor agonist R-phenylisopropyl adenosine reduces presumed pain behaviour in a rat model of central pain.

Abstract:

:Effects of intrathecally (i.t.) administered R-phenylisopropyl adenosine (R-PIA), an adenosine A1 receptor agonist, on presumed pain behaviour were assessed in a rat model of chronic central pain. Spinal cord injury was induced photochemically via laser irradiation of the spinal cord after intravenous injection of erythrosin B in rats. The chronic allodynia-like behaviour that developed in some animals was studied. R-PIA (3 and 10 nmol), injected i.t. reduced the mechanical and cold allodynia-like symptoms as tested with von Frey filaments and ethyl-chloride spray, respectively. No side effects were observed. The effect of R-PIA was significant for up to 5 h and was reversed by theophylline, an adenosine receptor antagonist.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Sjölund KF,von Heijne M,Hao JX,Xu XJ,Sollevi A,Wiesenfeld-Hallin Z

doi

10.1016/s0304-3940(98)00092-5

subject

Has Abstract

pub_date

1998-02-27 00:00:00

pages

89-92

issue

1-3

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(98)00092-5

journal_volume

243

pub_type

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