Abstract:
:Effects of intrathecally (i.t.) administered R-phenylisopropyl adenosine (R-PIA), an adenosine A1 receptor agonist, on presumed pain behaviour were assessed in a rat model of chronic central pain. Spinal cord injury was induced photochemically via laser irradiation of the spinal cord after intravenous injection of erythrosin B in rats. The chronic allodynia-like behaviour that developed in some animals was studied. R-PIA (3 and 10 nmol), injected i.t. reduced the mechanical and cold allodynia-like symptoms as tested with von Frey filaments and ethyl-chloride spray, respectively. No side effects were observed. The effect of R-PIA was significant for up to 5 h and was reversed by theophylline, an adenosine receptor antagonist.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Sjölund KF,von Heijne M,Hao JX,Xu XJ,Sollevi A,Wiesenfeld-Hallin Zdoi
10.1016/s0304-3940(98)00092-5subject
Has Abstractpub_date
1998-02-27 00:00:00pages
89-92issue
1-3eissn
0304-3940issn
1872-7972pii
S0304-3940(98)00092-5journal_volume
243pub_type
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