Abstract：
:Comparable to the anti-craving compound acamprosate, caroverine reduces alcohol withdrawal symptoms by an antagonism at ionotropic glutamate receptors and a blockade of calcium channels. The present study examines the effect of caroverine in a craving model, in which acamprosate has proved effective before. A place aversion was induced by a conditioned morphine withdrawal by administration of the opioid antagonist naloxone (0.1 mg/kg, s.c.) 5-6 days after the subcutaneous implantation of a morphine pellet in rats. Testing in the drug-free state, the acquisition of a conditioned aversion against the naloxone-associated cues was inhibited by pretreatment with caroverine (5 mg/kg, i.p.). This result corroborates the involvement of excitatory glutamate and calcium in the development of conditioned withdrawal and craving. It offers further evidence for the hypothesis that these neuronal systems are altered during withdrawal in a similar way by ethanol and opiates.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kratzer U,Schmidt WJdoi
10.1016/s0304-3940(03)00783-3keywords:
subject
Has Abstractpub_date
2003-10-02 00:00:00pages
91-4issue
2eissn
0304-3940issn
1872-7972pii
S0304394003007833journal_volume
349pub_type
杂志文章abstract：:Any given region of the cerebral cortex gets multiple inputs, and how these inputs are combined or selected is a key component of cortical function. Experiments in brain slices or other reduced preparations have shown that excitatory inputs to cortex produce a delayed feed-forward inhibition, which suggests that the r...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.02.036
更新日期：2008-04-25 00:00:00
abstract：INTRODUCTION:Several lines of evidence support an immunologic involvement in obsessive-compulsive disorder (OCD): the increased prevalence of OCD in patients with rheumatic fever (RF), and the aggregation of obsessive-compulsive spectrum disorders among relatives of RF probands. Tumor necrosis factor alpha is a proinfl...
journal_title：Neuroscience letters
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doi：10.1016/j.neulet.2008.07.022
更新日期：2008-09-12 00:00:00
abstract：:Copper, manganese and zinc were measured by flameless atomic absorption spectrophotometry in the developing brain of normal and quaking mice. The latter is a neurological mutant presenting early arrest of myelination. Copper concentration was increased by 200% between 10 and 20 days after birth and then leveled off in...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(87)90226-6
更新日期：1987-12-16 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)90723-4
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(85)90122-3
更新日期：1985-05-14 00:00:00
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doi：10.1016/j.neulet.2012.02.022
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journal_title：Neuroscience letters
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doi：10.1016/s0304-3940(02)01426-x
更新日期：2003-03-13 00:00:00
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journal_title：Neuroscience letters
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abstract：:To search for brain molecules that share epitopes with HIV (human immunodeficiency virus) proteins, we investigated non-AIDS human brains by immunohistochemical and Western blotting methods, and detected a 23 kDa protein which was immunoreactive with antibodies against HIVp17, a core protein of HIV with a molecular we...
journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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更新日期：1991-11-11 00:00:00
abstract：:Hemispheric asymmetries in spatial processing are generally considered to be responsible for the shorter reaction time (RT) of the left hand classically observed for right-handers when pointing at targets. Surprisingly, despite the special role which the right cerebral hemisphere is known to play in visual attention, ...
journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2001-11-23 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(92)90363-c
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.06.064
更新日期：2006-10-02 00:00:00
abstract：:Expression of vasoactive intestinal polypeptide (VIP) was studied in regenerating adult rat dorsal root ganglion (DRG) neurons in culture. VIP was not detected by radioimmunoassay in newly established cultures but increasing concentrations were observed between 2 and 4 days and VIP remained detectable for more than 2 ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90660-2
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(86)90249-1
更新日期：1986-10-30 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2007.07.046
更新日期：2007-09-13 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(87)90464-2
更新日期：1987-10-05 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2004-07-29 00:00:00
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journal_title：Neuroscience letters
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pub_type： 杂志文章
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更新日期：2010-01-29 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2001-05-18 00:00:00
abstract：:The transcriptional regulation of the gene encoding α-synuclein (SNCA) is thought to play a critical role in the pathogenesis of Parkinson's disease (PD), as common genetic variability in this gene is associated with an elevated risk of developing PD. However, the relevant mechanisms are still poorly understood. So fa...
journal_title：Neuroscience letters
pub_type： 杂志文章
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abstract：:Metabotropic glutamate receptors are selectively activated by 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). [3H]Glutamate binding sites in rat brain membranes were characterized in the presence of (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, and N-methyl-D-aspartate (N...
journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(97)00411-4
更新日期：1997-06-20 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(84)90056-9
更新日期：1984-08-10 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1981-09-25 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2007.03.040
更新日期：2007-05-18 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(88)90205-4
更新日期：1988-08-01 00:00:00
abstract：:We investigated the conduction velocity of motor and autonomic nerves, motor nerve to foot interosseous muscle and cervical vagus and sympathetic nerve, in streptozotocin diabetic rats (1-3 months duration of diabetes) and compared it with that of age-matched controls. In diabetic rats, the motor nerve conduction velo...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90489-v
更新日期：1990-05-18 00:00:00
