Abstract:
:In this study we evaluated oxidative stress (lipid peroxidation and protein oxidation) and thiol redox state [TRS: glutathione (GSH), glutathione disulfide (GSSG), cysteine (CSH), protein (P) thiols (PSH) and protein and non-protein (NP) mixed/symmetric disulfides (PSSR, NPSSR, NPSSC, PSSP)] in hippocampus after pentylenetetrazol (PTZ) administration at convulsive and subconvulsive dose. The significant decrease in PSH, CSH and NPSSC, as well as the increase in PSSP, NPSSR, lipid peroxidation and protein oxidation levels after PTZ-induced seizure indicate increased oxidative damage in hippocampus, although the levels of GSH and GSSG do not change significantly.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Patsoukis N,Zervoudakis G,Panagopoulos NT,Georgiou CD,Angelatou F,Matsokis NAdoi
10.1016/j.neulet.2003.10.080keywords:
subject
Has Abstractpub_date
2004-03-04 00:00:00pages
83-6issue
2eissn
0304-3940issn
1872-7972pii
S0304394003013454journal_volume
357pub_type
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