Abstract：
:There is increasing evidence that sleep may be involved in memory consolidation. However, there remain comparatively few studies that have explored the relationship between sleep and memory reconsolidation. At present study, we tested the effects of rapid eye movement sleep deprivation (RSD) on the reconsolidation of cued (experiment 1) and contextual (experiment 2) fear memory in rats. Behaviour procedure involved four training phases: habituation, fear conditioning, reactivation and test. Rats were subjected to 6h RSD starting either immediately after reactivation or 6h later. The control rats were returned to their home cages immediately after reactivation and left undisturbed. Contrary to those hypotheses speculating a potential role of sleep in reconsolidation, we found that post-reactivation RSD whether from 0 to 6h or 6 to 12h had no effect on the reconsolidation of both cued and contextual fear memory. However, our present results did not exclude the potential roles of non-rapid eye movement sleep in the reconsolidation of fear memory or sleep in the reconsolidation of other memory paradigms.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Tian S,Huang F,Li P,Ouyang X,Li Z,Deng H,Yang Ydoi
10.1016/j.neulet.2009.07.044subject
Has Abstractpub_date
2009-09-29 00:00:00pages
74-7issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(09)00980-Xjournal_volume
463pub_type
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