Abstract:
:The effects of microiontophoretic application of 5-hydroxytryptamine (5-HT) on the neuronal firing rate of the medial vestibular nucleus (MVN) were studied in anaesthetized rats. Ninety-three % of the units modified their background activity following 5-HT iontophoresis, enhancements of the firing rate being recorded in 42%, decreases in 38% and biphasic effects in 13%. 5-HT antagonists methysergide and ketanserin blocked the excitatory but not the inhibitory responses to 5-HT. These latter were, however, mimicked by 5-HT agonists 5-methoxy-N,N-dimethyltryptamine (5MeODMT) and 8-hydroxy-2(di-n-propyl-amino)tetralin (8-OH-DPAT). It is concluded that 5-HT can variously influence the background activity of MVN neurons and that 5-HT2 and probably 5-HT1A receptors are involved in the responses.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Licata F,Li Volsi G,Maugeri G,Santangelo Fdoi
10.1016/0304-3940(93)90205-ysubject
Has Abstractpub_date
1993-05-14 00:00:00pages
195-8issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(93)90205-Yjournal_volume
154pub_type
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