Abstract:
:Activation of several immediate early genes (IEGs) is crucial for long-term memory formation in vivo. In vitro methods of inducing these genes have not been investigated extensively. Here we present data demonstrating that application of the neurotrophin, nerve growth factor (NGF), to both rat primary neuronal cultures and differentiated mouse neuroblastoma 2A (N2A) cultures reliably induces expression of several IEGs, including Zif268, Nur77 and Arc, each of which have been linked to memory consolidation. These findings provide an in vitro model in which to test other agents that might modulate the induction of memory-associated genes.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Dickey CA,De Mesquita DD,Morgan D,Pennypacker KRdoi
10.1016/j.neulet.2004.04.089keywords:
subject
Has Abstractpub_date
2004-08-05 00:00:00pages
10-4issue
1eissn
0304-3940issn
1872-7972pii
S0304394004005646journal_volume
366pub_type
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