Na+,K(+)-ATPase activity in the cochlear lateral wall of the gerbil.

Abstract:

:We examined Na+,K(+)-ATPase activity in four regions of the gerbil cochlear lateral wall by measuring intracellular Na+ concentration ([Na+]i). The application of 1 mM ouabain and removal of external K+ caused a most striking increase in [Na+]i of the suprastrial fibrocytes, followed by the stria vascularis and the type II fibrocytes, but no detectable response in the type I fibrocytes. These results may imply the potency of the Na+,K(+)-ATPase activity. The high values of the resting [Na+]i in these cells under perilymph-like solution returned to the [Na+]i within physiological values after exposure to low-Na+ conditions similar to endolymph. Our results are interpreted in the light of recent morphological findings with regard to the roles in the secretion of K+ into endolymph of several cell types within the lateral wall.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Furukawa M,Ikeda K,Takeuchi S,Oshima T,Kikuchi T,Takasaka T

doi

10.1016/0304-3940(96)12862-7

subject

Has Abstract

pub_date

1996-08-09 00:00:00

pages

165-8

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304394096128627

journal_volume

213

pub_type

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