Age-dependent increase in [3H]verapamil binding to rat cortical membranes.

abstract：:Carrier-mediated transport of small peptides and peptidomimetics offers the opportunity for a targeted drug delivery across cell membranes in the central nervous system (CNS). This process is mediated by the proton-coupled transporter PEPT2 which is expressed in glial and choroid plexus cells. In the present studies, ...

journal_title：Neuroscience letters

authors： Groneberg DA,Rubio-Aliaga I,Nickolaus M,Döring F,Fischer A,Daniel H

更新日期：2004-06-24 00:00:00

abstract：:This study explored whether patients with Parkinson's disease alter the regulation of upright standing according to constraints imposed by the environmental context. The provision of context-dependent adaptations was inferred from the presence of adjustments to standing postural control that would serve to reduce fall...

journal_title：Neuroscience letters

authors： Brown LA,Doan JB,Whishaw IQ,Suchowersky O

更新日期：2007-05-18 00:00:00

abstract：:Muscle fatigue is known to be associated with a deteriorated muscle coordination and impaired movement performance in variety of voluntary movements. The aim of this study was to investigate the generally underexplored effect of muscle fatigue on both the coordination between grip force (GF; the force component perpen...

journal_title：Neuroscience letters

authors： Emge N,Prebeg G,Uygur M,Jaric S

更新日期：2013-08-29 00:00:00

abstract：:Recent studies have described the role of various regions of the neural cell adhesion molecule (NCAM) in cell-cell interactions. Monoclonal antibodies (L2/HNK-1) directed against a sulfated, glucuronic acid-containing, N-linked carbohydrate epitope have also been shown to inhibit NCAM-mediated neural cell adhesion. In...

journal_title：Neuroscience letters

authors： Cole GJ,Schachner M,Fliesler SJ

更新日期：1988-11-11 00:00:00

abstract：:We assessed whether tolerance develops to the antinociceptive effect of intrathecal (i.t.) orphanin FQ, the endogenous ligand of the orphan opioid-like receptor, and whether there is a cross-tolerance between the antinociceptive effect of i.t. orphanin FQ and the mu opioid receptor agonist morphine. Orphanin FQ admini...

journal_title：Neuroscience letters

authors： Hao JX,Wiesenfeld-Hallin Z,Xu XJ

更新日期：1997-02-14 00:00:00

abstract：:3,4-Methylenedioxymethamphetamine (MDMA) is an illegal drug that can induce life-threatening hyperthermia. No effective pharmacological treatment for MDMA-induced hyperthermia has yet been established. We investigated the effects of memantine, a non-competitive N-methyl-D-aspartate (NMDA)-type glutamate receptor antag...

journal_title：Neuroscience letters

authors： Nisijima K,Kuboshima K,Shioda K,Yoshino T,Iwamura T,Kato S

更新日期：2012-12-07 00:00:00

abstract：:Intracellular recordings were made from rat striatal neurones in vitro. In the presence of intracellular caesium and extracellular tetraethylammonium chloride (TEA) (5 mM) and barium (3 mM), long-lasting plateau potentials developed followed by a prominent voltage independent hyperpolarization which lasted several sec...

journal_title：Neuroscience letters

authors： Cherubini E,Lanfumey L

更新日期：1987-08-05 00:00:00

abstract：:The structure of CACNA1G, the gene encoding alpha1G, a human brain T Ca2+ channel alpha1 subunit, was determined by comparison of polymerase chain reaction-amplified brain cDNA and genomic sequences. The gene consists of at least 38 exons, two of them newly-identified, spanning at least 66490 basepairs of chromosome 1...

journal_title：Neuroscience letters

authors： Mittman S,Guo J,Agnew WS

更新日期：1999-10-29 00:00:00

abstract：:Application of a GABAA (gamma-aminobutyric acid-A) receptor antagonist through a microdialysis probe into the forelimb primary motor cortex of ketamine-anesthetized rats induced electromyographic activity in the contralateral forelimb. This activity consisted of spontaneous forelimb movements with a frequency of 0.8 +...

journal_title：Neuroscience letters

authors： Castro-Alamancos MA,Borrell J

更新日期：1993-02-19 00:00:00

abstract：:The accumulation of choline acetyltransferase (CAT) proximal to and nerve growth factor (NGF) distal to the intraneural site of tetrodotoxin (TTX) or batrachotoxin (BTX) injection in vivo was used to monitor orthograde and retrograde axonal transport. Orthograde axonal transport was blocked by BTX for up to 7-10 days ...

journal_title：Neuroscience letters

authors： Boegman RJ,Riopelle RJ

更新日期：1980-06-01 00:00:00

abstract：:A new method for on-line analysis of in vivo differential normal pulse voltammograms is reported. They are fitted by least squares to an expression describing the contribution of different electroactive species and the baseline. Its validity for resolving ascorbate (AA), dopamine (DA) and DOPAC signals is evidenced by...

journal_title：Neuroscience letters

authors： Gonzalez-Mora JL,Sanchez-Bruno JA,Mas M

更新日期：1988-03-21 00:00:00

abstract：:Contact heat evoked potentials (CHEPs) have been difficult to elicit due to slow temperature rise times. A recently developed heat-foil technology was used to elicit pain and CHEPs. Two groups of subjects were separately stimulated at the left arm with contact heat via one fast-acting (70 degrees C/s) heat-foil thermo...

journal_title：Neuroscience letters

authors： Chen AC,Niddam DM,Arendt-Nielsen L

更新日期：2001-12-01 00:00:00

abstract：:Cochlear hair cell loss results in the secondary loss of spiral ganglion cells (SGCs). The death of these SGCs is due to apoptosis. The E2F1-cyclin dependent kinase 1 (CDK1) pathway is believed to represent an important mechanism of neuronal cell death. However, the role of this pathway in spiral ganglion neuronal apo...

journal_title：Neuroscience letters

authors： Liu YY,Wang GP,Peng Z,Guo JY,Wu Q,Xie J,Gong SS

更新日期：2016-03-23 00:00:00

abstract：:Pain is the most characteristic feature of sickle cell disease (SCD). Patients with SCD live with unpredictable, recurrent episodes of acute painful crisis, as well as chronic unremitting pain throughout their lifetime. While most of the research and medical efforts have focused on treating vaso-occlusion crisis and a...

journal_title：Neuroscience letters

authors： He Y,Wang ZJ

更新日期：2019-07-27 00:00:00

abstract：:Comparable to the anti-craving compound acamprosate, caroverine reduces alcohol withdrawal symptoms by an antagonism at ionotropic glutamate receptors and a blockade of calcium channels. The present study examines the effect of caroverine in a craving model, in which acamprosate has proved effective before. A place av...

journal_title：Neuroscience letters

authors： Kratzer U,Schmidt WJ

更新日期：2003-10-02 00:00:00

abstract：:Sciatic axotomy in 2-day-old rats (P2) causes lumbar motoneuron loss, which could be associated with nitric oxide (NO) production. NO may be produced by three isoforms of synthase (NOS): neuronal (nNOS), endothelial (eNOS) and inducible (iNOS). We investigated NOS expression and NO synthesis in the lumbar enlargement ...

journal_title：Neuroscience letters

authors： Rogério F,Teixeira SA,Júnior HJ,Maria CC,Vieira AS,de Rezende AC,Pereira GA,Muscará MN,Langone F

更新日期：2006-10-23 00:00:00

abstract：:The relationship between pain severity and the extent of injury to a peripheral nerve remains elusive. In this study, we compared the pain behavior resulting from partial (1/3-1/2 thickness) and full L5 spinal nerve ligation (SNL) in rats. The decrease in paw withdrawal threshold (PWT) to mechanical stimuli in the hin...

journal_title：Neuroscience letters

authors： Guan Y,Yuan F,Carteret AF,Raja SN

更新日期：2010-02-26 00:00:00

abstract：:Many gene expression studies have examined postmortem brain tissues of patients with schizophrenia. However, only a few expression studies of the genes identified in genome-wide association study (GWAS) have been published to date. We measured the expression levels of the genes identified in GWAS (ZNF804A, OPCML, RPGR...

journal_title：Neuroscience letters

authors： Umeda-Yano S,Hashimoto R,Yamamori H,Weickert CS,Yasuda Y,Ohi K,Fujimoto M,Ito A,Takeda M

更新日期：2014-05-07 00:00:00

abstract：:In this study, we investigated the role of nitric oxide (NO) in neuronal cell death in the lipopolysaccharide (LPS)-treated rat hippocampal slice culture. Neuronal cell death was induced after a LPS treatment in a rat hippocampal slice. The region and time course of the cell death caused by LPS were different from tho...

journal_title：Neuroscience letters

authors： Lee P,Son D,Lee J,Kim YS,Kim H,Kim SY

更新日期：2003-09-25 00:00:00

abstract：:Bipolar disorder (BD) is a debilitating mental disorder with complex clinical manifestations and low diagnostic accuracy. Depressive episodes are most common in the course of BD with high comorbidity and suicide rates, which present greater clinical challenges than mania and hypomania episodes. However, there are no o...

journal_title：Neuroscience letters

authors： Ren Y,Chen ZZ,Sun XL,Duan HJ,Tian JS,Wang JY,Yang H

更新日期：2021-01-18 00:00:00

abstract：:Five min bilateral carotid artery occlusion (BCO) in gerbils results in selective degeneration of neurons in the hippocampus, striatum and cortex, and an increase in spontaneous locomotor activity. These phenomena were examined to determine if an association could be made between the site or degree of neuronal degener...

journal_title：Neuroscience letters

authors： Mileson BE,Schwartz RD

更新日期：1991-07-08 00:00:00

abstract：:Hippocampal neurogenesis is potentially implicated in etiology of depression and as the final common mechanism underlying antidepressant treatments. However, decreased neurogenesis has not been demonstrated in depressed patients and, in animals, reduced cytogenesis was shown in healthy rats exposed to stressors, but, ...

journal_title：Neuroscience letters

authors： Petersén A,Wörtwein G,Gruber SH,Mathé AA

更新日期：2008-05-16 00:00:00

abstract：:Throughout life, new neurons are continuously generated from subventricular zone and added to the olfactory bulb (OB). Because a subset of mature OB neurons undergoes spontaneous cell death, adult OB neurogenesis serves for the replacement of this cell loss. Spontaneous cell turnover should alter the neuronal circuits...

journal_title：Neuroscience letters

authors： Kim WR,Sun W

更新日期：2013-08-26 00:00:00

abstract：:The high-affinity of [3H]gamma-aminobutyric acid (GABA) to GABAA receptors and [3H]baclofen to GABAB receptors were studied in the cerebellum of pyridoxine-deficient rats and compared to pyridoxine-supplemented controls. There was a significant increase in the maximal binding (Bmax) of both GABAA and GABAB receptors w...

journal_title：Neuroscience letters

authors： Paulose CS,Dakshinamurti K

更新日期：1984-08-10 00:00:00

abstract：:ATP is an important extracellular messenger in the CNS. In the hippocampus, a brain structure relevant for learning and memory processes, it acts both as a modulator and as a mediator of synaptic transmission, with implications for synaptic plasticity phenomena. Recent evidence suggests that ATP modulates activity-dep...

journal_title：Neuroscience letters

authors： da Silva BM,de Mendonça A,Ribeiro JA

更新日期：2005-08-05 00:00:00

abstract：:In striatal neurons in primary culture quisqualate potently stimulated the formation of inositol phosphates via a metabotropic receptor we recently termed Qp in order to distinguish it from the classical ionotropic quisqualate receptor termed Qi. Here we show that 10 microM of quisqualate activated in a rapid and tran...

journal_title：Neuroscience letters

authors： Manzoni OJ,Finiels-Marlier F,Sassetti I,Blockaert J,le Peuch C,Sladeczek FA

更新日期：1990-02-05 00:00:00

abstract：:The opioid peptide dynorphin A(1-8) (1 micron) increased acetylcholine release from the Torpedo electric organ by approximately twofold. This effect was reversed by the opiate antagonist naloxone. The effect of Dyn A(1-8) on acetylcholine release was found to vary in magnitude with the seasons of the year, with maxima...

journal_title：Neuroscience letters

authors： Oron L,Sarne Y,Michaelson DM

更新日期：1991-04-29 00:00:00

abstract：:Addicsin is a murine homologue of rat glutamate-transporter-associated protein 3-18 (GTRAP3-18), a putative modulator of neural glutamate-transporter excitatory amino acid carrier 1 (EAAC1). The other molecular functions of addicsin, however, remain largely unknown. We analyzed here the regional and cellular distribut...

journal_title：Neuroscience letters

authors： Inoue K,Akiduki S,Ikemoto MJ

更新日期：2005-10-07 00:00:00

abstract：:Our previous genetic and proteomic studies demonstrated that dynamin 1 is significantly associated with nicotine dependence (ND) in human smokers and its expression is highly modulated by nicotine in the brains of animals. To provide further molecular evidence for the involvement of dynamin 1 in the etiology of ND, we...

journal_title：Neuroscience letters

authors： Xu Q,Li MD

更新日期：2011-02-11 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) and insulin promote the survival of 6-7 day old post-natal rat cerebellar granule cells. Previous studies using the PI3 kinase inhibitor, wortmannin and the over-expression of protein kinase B (PKB) have indicated that both PI3 kinase and PKB activation are central for insulin-...

journal_title：Neuroscience letters

authors： Foulstone EJ,Tavaré JM,Gunn-Moore FJ

更新日期：1999-04-02 00:00:00