Anterior cingulate GABA levels predict whole-brain cerebral blood flow.

abstract：:The opioid peptide dynorphin decreased somatic calcium-dependent action potential duration in a portion of mouse dorsal root ganglion (DRG) neurons without altering resting membrane potential or conductance. Dynorphin action was antagonized by naloxone. Responses of DRG neurons to dynorphin differed from responses to ...

journal_title：Neuroscience letters

authors： Werz MA,Macdonald RL

更新日期：1984-05-04 00:00:00

abstract：:The number of principal neurons in the rat superior cervical ganglion (SCG) exhibiting enkephalin-peptide immunoreactivity is reported to be limited. To better determine the degree of enkephalinergic phenotype in sympathetic neurons, sections of SCGs from rats aged newborn to adult were processed for in situ hybridiza...

journal_title：Neuroscience letters

authors： Greif KF

更新日期：1994-10-24 00:00:00

abstract：:The ability of increases in extracellular potassium ([K+]o) and/or decreases in extracellular calcium ([Ca2+]o) to induce epileptiform activity in hippocampal slices was studied by systematically varying [K+]o and [Ca2+]o. Slices prepared from kindled rats, both 1 week and 1 month after the last kindled seizure, showe...

journal_title：Neuroscience letters

authors： Stringer JL,Lothman EW

更新日期：1988-06-17 00:00:00

abstract：:DSP-4[N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride] is a neurotoxin that depletes norepinephrine. The catecholaminergic system has been implicated in the regulation of blood glucose level. In the present study, the effect of DSP-4 administered intracerebroventricularly (i.c.v.) or intrathecally (i.t.) on...

journal_title：Neuroscience letters

authors： Park SH,Kim SS,Lee JR,Sharma N,Suh HW

更新日期：2016-05-04 00:00:00

abstract：:We examined Na+,K(+)-ATPase activity in four regions of the gerbil cochlear lateral wall by measuring intracellular Na+ concentration ([Na+]i). The application of 1 mM ouabain and removal of external K+ caused a most striking increase in [Na+]i of the suprastrial fibrocytes, followed by the stria vascularis and the ty...

journal_title：Neuroscience letters

authors： Furukawa M,Ikeda K,Takeuchi S,Oshima T,Kikuchi T,Takasaka T

更新日期：1996-08-09 00:00:00

abstract：:The Chronic Constriction Injury of the Infraorbital Nerve (CCI-ION) is a well-established model to study facial sensory changes related to trigeminal neuropathic pain. CCI-ION induces heat hypersensitivity that resolves within 2-3 weeks and a delayed mechanical hypersensitivity that emerges during the second week post...

journal_title：Neuroscience letters

authors： Nones CFM,Claudino RF,Ferreira LEN,Dos Reis RC,King T,Chichorro JG

更新日期：2017-03-22 00:00:00

abstract：:Recent evidence suggests that among the factors that lead to neurodegenerative changes in Parkinson's disease are stimulation of lipid peroxidation and deficiency of glutathione and glutathione peroxidase in substantia nigra. We have investigated the effect of neurodegenerative changes on plasma and erythrocytes of pa...

journal_title：Neuroscience letters

authors： Kilinç A,Yalçin AS,Yalçin D,Taga Y,Emerk K

更新日期：1988-05-03 00:00:00

abstract：:Addicsin is a murine homologue of rat glutamate-transporter-associated protein 3-18 (GTRAP3-18), a putative modulator of neural glutamate-transporter excitatory amino acid carrier 1 (EAAC1). The other molecular functions of addicsin, however, remain largely unknown. We analyzed here the regional and cellular distribut...

journal_title：Neuroscience letters

authors： Inoue K,Akiduki S,Ikemoto MJ

更新日期：2005-10-07 00:00:00

abstract：:Alpha-2 macroglobulin (A2M) is a serum pan-protease inhibitor that is related with the pathogenesis of Alzheimer's disease (AD) through its ability to mediate amyloid beta degradation. Recently, it has been reported that the I1000V polymorphism in A2M gene might increase the risk of AD. In the present study, we invest...

journal_title：Neuroscience letters

authors： Shibata N,Ohnuma T,Takahashi T,Ohtsuka E,Ueki A,Nagao M,Arai H

更新日期：2000-08-25 00:00:00

abstract：:The purpose of this study was to investigate how the recruitment gain, as derived from the Hoffmann (H)-reflex measurement, of antagonistic motoneurons is modulated during voluntary lengthening (LEN) and shortening (SHO) contractions in the human tibialis anterior (TA) muscle. To this end, the parameters of the ratios...

journal_title：Neuroscience letters

authors： Sekiguchi H,Nakazawa K,Akai M

更新日期：2003-05-15 00:00:00

abstract：:The medial septal area (MSA) contains cholinergic and GABAergic neurons that send projections to the hippocampus. These neurons have both cholinergic and GABAergic receptors. This study was designed to determine the effects of intraseptal infusions of cholinergic and GABAergic drugs, which alter mnemonic processes, on...

journal_title：Neuroscience letters

authors： Gorman LK,Pang K,Frick KM,Givens B,Olton DS

更新日期：1994-01-31 00:00:00

abstract：:Isolated Helix neurons were internally perfused under voltage-clamp, with drugs applied by the 'concentration clamp' which allowed an extremely rapid switching of the external solution. 4-Aminopyridine (4-AP) at more than 3 X 10(-4) M induced a chloride current (ICl) which could be blocked by D-tubocurarine. Acetylcho...

journal_title：Neuroscience letters

authors： Ikemoto Y,Akaike N,Ono K

更新日期：1987-04-23 00:00:00

abstract：:Neuronal recording and neuroimaging studies have shown that the primary motor area (M1) not only participates in motor execution, but is also engaged during movement preparation. The purpose of the present study was to map the distribution of the preparation- and execution-related activity within the contralateral M1 ...

journal_title：Neuroscience letters

authors： Zang Y,Jia F,Weng X,Li E,Cui S,Wang Y,Hazeltine E,Ivry R

更新日期：2003-02-06 00:00:00

abstract：:The neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on striatal total biopterin were examined both in rats and mice at different time courses. Results indicate that MPTP caused a significant decrease of total biopterin content in the striatum of mice. This effect occurred as soon as 6 h after...

journal_title：Neuroscience letters

authors： Lee EH

更新日期：1988-06-07 00:00:00

abstract：:The chronic administration of phencyclidine-HCl (PCP-HCl), 10 mg/kg, for 6-7 days resulted in a significant increase in the striatal methionine-enkephalin level, although acute administration induced no change of methionine-enkephalin level in this area. The methionine-enkephalin levels in other areas investigated, i....

journal_title：Neuroscience letters

authors： Nabeshima T,Hiramatsu M,Amano M,Furukawa H,Kameyama T

更新日期：1983-05-27 00:00:00

abstract：:Recent findings from our and other laboratories indicate that cell cycle-related phenomena may play a key role in the formation of Alzheimer-type pathology and neuronal cell death in both Alzheimer's and cerebro-vascular diseases. In this study we examine the expression patterns of cyclins A, B1, D1 and E in neuronal ...

journal_title：Neuroscience letters

authors： Smith MZ,Nagy Z,Esiri MM

更新日期：1999-08-13 00:00:00

abstract：:The autoradiographic [14C]2-deoxyglucose (2-DG) method was used to map the descending effects of midbrain reticular stimulation on the rat cervical spinal cord. The stimulation evoked consistently a defensive 'freezing' reaction as well as a large and highly localized increase in 2-DG uptake in the substantia gelatino...

journal_title：Neuroscience letters

authors： Gonzalez-Lima F

更新日期：1986-04-24 00:00:00

abstract：:Excitatory amino acid (EAA) receptor-mediated events have recently been implicated in dopaminergic mechanisms of neurotoxicity. 2,4,5-Trihydroxyphenylalanine (6-hydroxy-DOPA, TOPA), the ortho-hydroxylated derivative of the dopamine precursor 2,4-dihydroxyphenylalanine (L-DOPA), has recently been reported to have neuro...

journal_title：Neuroscience letters

authors： Cha JH,Dure LS IV,Sakurai SY,Penney JB,Young AB

更新日期：1991-10-28 00:00:00

abstract：:Several studies have demonstrated that the human motor cortex is activated by the mere observation of actions performed by others. In the present study, we explored whether the perception of 'impoverished motion stimuli', such as shadow animations, is sufficient to activate motor areas. To do so, transcranial magnetic...

journal_title：Neuroscience letters

authors： Alaerts K,Van Aggelpoel T,Swinnen SP,Wenderoth N

更新日期：2009-09-25 00:00:00

abstract：:APPsw transgenic mice showing substantial features of brain Abeta amyloidosis such as senile plaques and behavioral abnormalities were examined by immunostaining to determine whether Abeta deposits could induce the subsequent disturbance of neurotransmitter systems including somatostatin, substance P and choline acety...

journal_title：Neuroscience letters

authors： Tomidokoro Y,Harigaya Y,Matsubara E,Ikeda M,Kawarabayashi T,Okamoto K,Shoji M

更新日期：2000-10-13 00:00:00

abstract：:Effects of the 1-methyl-4-phenylpyridinium ion (MPP+) on DOPA formation and phosphorylation of tyrosine hydroxylase (TH) of rat pheochromocytoma PC12h cells were examined after the cells were cultured with MPP+. DOPA formed from endogenous tyrosine in PC12h cells after a 3-day culture with 100 microM MPP+ was decrease...

journal_title：Neuroscience letters

authors： Kiuchi K,Hagiwara M,Hidaka H,Nagatsu T

更新日期：1988-06-29 00:00:00

abstract：:Cutaneous Meissner corpuscles depend for development and survival exclusively on the NT system TrkB/BDNF/NT-4 unlike other types of sensory corpuscles and nerve endings, which have very complex neuronal and growth factor dependence. However, the pattern of expression of TrkB in human Meissner corpuscles is not known. ...

journal_title：Neuroscience letters

authors： Calavia MG,Feito J,López-Iglesias L,de Carlos F,García-Suarez O,Pérez-Piñera P,Cobo J,Vega JA

更新日期：2010-01-04 00:00:00

abstract：:Cancer patients with bone metastases often suffer breakthrough pain. However, little progress has been made in the treatment of breakthrough pain and its associated mechanism(s) in the patient with cancer due to lacking of resembling and predictive animal models. We previously have demonstrated that endothelin-1 plays...

journal_title：Neuroscience letters

authors： Tang Y,Peng H,Liao Q,Gan L,Zhang R,Huang L,Ding Z,Yang H,Yan X,Gu Y,Zang X,Huang D,Cao S

更新日期：2016-03-23 00:00:00

abstract：:Exposure of rat hippocampal neurons to the peptide amyloid beta (A beta) (25-35) as well as A beta (1-40) peptides enhances phosphorylation of tau to a paired helical filament (PHF)-state through activation of tau protein kinase I (TPK I)/glycogen synthase kinase-3 beta (GSK-3 beta) [Busciglio, J., Lorenzo, A., Yeh, J...

journal_title：Neuroscience letters

authors： Takashima A,Noguchi K,Michel G,Mercken M,Hoshi M,Ishiguro K,Imahori K

更新日期：1996-01-12 00:00:00

abstract：:We raised polyclonal antibodies against a gene product responsible for late infantile neuronal ceroid lipofuscinosis (CLN2). By Western blotting, all three antisera recognized the CLN2 protein at approximately 49 kDa in human brain homogenates. Immunohistochemistry using the antisera demonstrated the granular labellin...

journal_title：Neuroscience letters

authors： Oka A,Kurachi Y,Mizuguchi M,Hayashi M,Takashima S

更新日期：1998-11-27 00:00:00

abstract：:Parkinson's disease (PD) is a multifactorial disease caused by both genetic and environmental factors. Alpha-synuclein is of particular interest in PD since it is a major component of Lewy bodies and mutations in the alpha-synuclein gene were identified in familial PD. Oxidative stress and proteasomal dysfunction are ...

journal_title：Neuroscience letters

authors： Lev N,Melamed E,Offen D

更新日期：2006-05-15 00:00:00

abstract：:In CA3 pyramidal neurons of guinea pig hippocampal slices an outward current activated by the GABAB agonist, baclofen (0.3 microM, Ibac) was reduced by low concentrations of carbachol (Cch, 0.1-0.3 microM). The effect of Cch desensitized suggesting that the receptor subtype involved in this muscarinic effect of Cch wa...

journal_title：Neuroscience letters

authors： Müller W,Brunner H,Misgeld U

更新日期：1989-05-22 00:00:00

abstract：:The present magnetoencephalographic study was conducted in order to assess the accuracy of dipole localizations for the movement-evoked field component 1 (MEF 1). Three male subjects were requested to perform self-paced flexions of their index finger and thumb in repeated sessions of 60 trials while the neuromagnetic ...

journal_title：Neuroscience letters

authors： Rosburg T,Weiss T,Haueisen J,Nowak H,Sauer H

更新日期：1996-08-30 00:00:00

abstract：:Mutations in presenilins are the major cause of early onset familial Alzheimer disease. It has recently been argued that clinical presenilin mutations work as loss-of-function but not toxic gain-of-function. To investigate whether presenilins are involved in the regulation of the distribution of neuronal membrane lipi...

journal_title：Neuroscience letters

authors： Oikawa N,Goto M,Ikeda K,Taguchi R,Yanagisawa K

更新日期：2012-09-06 00:00:00

abstract：:The pineal product melatonin that acts on specific melatonin receptors has been implicated in pathobiological mechanisms of neuropsychiatric disorders including Alzheimer's disease. We used mice lacking melatonin MT(2) receptors (MT(2) knockouts) to investigate the role of these receptors in synaptic plasticity and le...

journal_title：Neuroscience letters

authors： Larson J,Jessen RE,Uz T,Arslan AD,Kurtuncu M,Imbesi M,Manev H

更新日期：2006-01-23 00:00:00