Abstract:
:Tritiated dipyridamole, a specific adenosine uptake inhibitor binds in a saturable and reversible fashion to high-affinity receptor sites in guinea pig brain sections (Kd = 10 +/- 1.5 nM; Bmax = 650 +/- 100 fmol/mg prot.). The anatomical distribution of [3H]dipyridamole binding sites obtained with autoradiographic techniques shows a widespread but heterogeneous distribution of the binding sites throughout the whole guinea pig brain. Very high densities of binding sites are observed in the cerebellar cortex (molecular layer), the pyriform cortex, the superior colliculus (superficial layer), the supraoptic nucleus and the nucleus of the tractus solitarius. The anatomical characterization of the adenosine uptake site, using [3H]dipyridamole as a probe, may be useful to determine the functional role of adenosine in the brain.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Bisserbe JC,Deckert J,Marangos Pdoi
10.1016/0304-3940(86)90043-1subject
Has Abstractpub_date
1986-05-23 00:00:00pages
341-5issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(86)90043-1journal_volume
66pub_type
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