A novel haplotype of spinocerebellar ataxia type 6 contributes to the highest prevalence in western Japan.

abstract：:We previously reported that Tyr-Leu (YL) exhibits potent anxiolytic-like activity comparable to diazepam in mice. In the current study, we revealed that aromatic amino acid-Leu, Phe-Leu and Trp-Leu (FL and WL, respectively), exhibited anxiolytic-like activity in the elevated plus-maze and open-field tests. FL and WL w...

journal_title：Neuroscience letters

authors： Mizushige T,Kanegawa N,Yamada A,Ota A,Kanamoto R,Ohinata K

更新日期：2013-05-24 00:00:00

abstract：:Current diagnosis of Major depressive disorder (MDD) depends on its clinical symptoms, not on the results of any laboratory examinations. Establishing biological markers for diagnosis of MDD is one of the most important problems to be solved in psychiatry practice. MDD patients (n=8) and a healthy control group (n=8) ...

journal_title：Neuroscience letters

authors： Wei K,Xue HL,Guan YH,Zuo CT,Ge JJ,Zhang HY,Liu BJ,Cao YX,Dong JC,Du YJ

更新日期：2016-08-26 00:00:00

abstract：:Oxidative stress is considered important for the pathogenesis of Alzheimer disease (AD), which is characterized by the formation of senile plaques rich in amyloid beta-protein (Abeta). Abeta cytotoxicity has been found dependent on lysosomes, which are abundant in AD neurons and are shown to partially co-localize with...

journal_title：Neuroscience letters

authors： Zheng L,Roberg K,Jerhammar F,Marcusson J,Terman A

更新日期：2006-02-20 00:00:00

abstract：:Ethanol withdrawal is a serious clinical problem owing in part to over stimulation of ionotropic glutamate receptors in the brain and is linked to elevated oxidative damage. In this study, we tested the hypothesis that lipid peroxidation is elevated in the brain tissue of rats fed an ethanol-containing diet for 6 week...

journal_title：Neuroscience letters

authors： Milne GL,Morrow JD,Picklo MJ Sr

更新日期：2006-09-25 00:00:00

abstract：:Focal ischemia was induced in the fronto-parietal region of rat brain, by injection of Rose Bengal, followed by light activation. Focal ischemia was accompanied by formation of PGD(2) peaking 60-90 min post irradiation and declining thereafter. Increased Cycloxygenase-2 (COX-2) expression was also observed. Control is...

journal_title：Neuroscience letters

authors： Govoni S,Masoero E,Favalli L,Rozza A,Scelsi R,Viappiani S,Buccellati C,Sala A,Folco G

更新日期：2001-05-04 00:00:00

abstract：:Previous studies have shown that striatum and nucleus accumbens (NAc) are two different structures in mediating addictive drug-induced ascorbic acid (AA) release. In order to further characterize the different effects of drugs-induced AA release in the striatum and NAc, in the present study, we investigated the effect...

journal_title：Neuroscience letters

authors： Gu PF,Wu CF,Yang JY,Shang Y,Hou Y,Bi XL,Dai F

更新日期：2006-05-15 00:00:00

abstract：:To determine whether axonal terminals emanating from the central nucleus of amygdala (Ce) to the parabrachial nucleus (PBN) contain gamma-aminobutyric acid (GABA) as their neurotransmitter, an electron microscopic study was performed employing the combined techniques of WGA-HRP anterograde tracing and post-embedding i...

journal_title：Neuroscience letters

authors： Jia HG,Zhang GY,Wan Q

更新日期：2005-07-01 00:00:00

abstract：:Stimulation of G-proteins coupled with metabotropic glutamate receptors (mGlu receptors) was investigated by means of guanosine-5'-O-(3-[(35)S]thio)triphosphate ([(35)S]GTPγS) binding assay in rat hippocampal and striatal membranes. The endogenous ligand l-glutamate increased specific [(35)S]GTPγS binding in a concent...

journal_title：Neuroscience letters

authors： Odagaki Y,Kinoshita M,Toyoshima R

更新日期：2013-02-28 00:00:00

abstract：:Remacemide is a potential anticonvulsant drug with an active metabolite, desglycinyl-remacemide (DGR). Both moieties have been reported to block neuronal Na(+) channels and the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor. The effects of remacemide and DGR on zero Mg(2+)/4-aminopyridine-induced epileptifo...

journal_title：Neuroscience letters

authors： Santangeli S,Sills GJ,Stone TW,Brodie MJ

更新日期：2002-03-15 00:00:00

abstract：:Single-site variants in the calmodulin-binding domain of RC3/neurogranin were heterologously expressed in Xenopus oocytes to examine their effects on serotonin-evoked currents. RC3 variants serine36 -->alanine (Ser36-->Ala), serine36-->glycine (Ser36-->Gly), and phenylalanine37-->tryptophan (Phe37-->Trp), which bind c...

journal_title：Neuroscience letters

authors： Watson JB,Margulies JE,Coulter PM 2nd,Gerendasy DD,Sutcliffe JG,Cohen RW

更新日期：1996-11-29 00:00:00

abstract：:Intra- and extracellular recordings from the in vitro rat hippocampal slice preparation have been used to investigate the influence of serotoninergic, adrenergic and cholinergic receptor antagonists on the excitability of CA1 pyramidal neurones. The serotonin receptor antagonist 4-amino-N-(1-azabicyclo[2.2.2]oct-3yl)-...

journal_title：Neuroscience letters

authors： Siarey RJ,Andreasen M,Lambert JD

更新日期：1995-10-27 00:00:00

abstract：:Voltage-gated Na+ currents were recorded from anatomically identified postganglionic muscular sympathetic neurons without and with ATP and GTP in the intracellular solution. The main findings of the study were that cells without ATP and GTP in the intracellular solution express a higher amplitude and greater density o...

journal_title：Neuroscience letters

authors： Rola R,Szulczyk P

更新日期：2004-04-08 00:00:00

abstract：:The cellular localisation of benzodiazepine receptors was studied. Kainic acid induced neuronal lesions (2 x 0.25-2 x 2 micrograms; 2-26 days in rat cerebellum decreased specific binding of [3H]flunitrazepam down to 35% of controls. Specific binding of [3H]flunitrazepam was also decreased (to 80% of controls) in the c...

journal_title：Neuroscience letters

authors： Braestrup C,Nielsen M,Biggio G,Squires RF

更新日期：1979-08-01 00:00:00

abstract：:In rats anesthetized with pentobarbital or a mixture of urethane and chloralose, horseradish peroxidase (HRP) was injected into the intermediolateral column of the spinal cord (Th7 and Th9) or the posterior pituitary lobe. HRP positive cells were found mainly in the dorsomedial part of the paraventricular nuclease (PV...

journal_title：Neuroscience letters

authors： Ono T,Nishino H,Sasaka K,Muramoto K,Yano I,Simpson A

更新日期：1978-11-01 00:00:00

abstract：:In freely moving rats, effects of unilateral haloperidol injection into the substantia nigra were monitored with in vivo voltammetry in the bilateral striata. The electrochemical responses at 120 mV versus Ag-AgCl, reflecting mainly a level of 3,4-dihydroxyphenylacetic acid (DOPAC), increased both in the striata withi...

journal_title：Neuroscience letters

authors： Kato T,Ishii K,Ikeda M

更新日期：1984-09-07 00:00:00

abstract：:Precise evaluation of the ascending reticular activating system (ARAS) is important for diagnosis, prediction of prognosis, and management of patients with disorders of impaired consciousness. In the current study, we attempted to reconstruct the direct neural pathway between the brainstem reticular formation (RF) and...

journal_title：Neuroscience letters

authors： Jang SH,Kwon HG

更新日期：2015-10-08 00:00:00

abstract：:Small-fiber neuropathy was induced in young adult mice by intraperitoneal injection of resiniferatoxin (RTX), a TRPV1 agonist. At day 7, RTX induced significant thermal and mechanical hypoalgesia. At day 28, mechanical and thermal nociception were restored. No nerve degeneration in skin was observed and unmyelinated n...

journal_title：Neuroscience letters

authors： Danigo A,Magy L,Richard L,Sturtz F,Funalot B,Demiot C

更新日期：2014-06-13 00:00:00

abstract：:The present study examined perception of individual finger forces during multi-finger force production tasks. In an ipsilateral force matching paradigm, 12 healthy subjects were instructed to produce a reference force pre-determined at 30% MVC of involved fingers (varying from 1 to 4 fingers, visual feedback of total ...

journal_title：Neuroscience letters

authors： Li S

更新日期：2006-12-06 00:00:00

abstract：:Membrane microdomains (MDs), or lipid rafts, are recently identified dynamic membrane domains on which various signal-transductions are performed. Intracellular Ca(2+)-binding proteins participate in the Ca(2+) signaling through interaction with various proteins. Neurocalcin alpha (NCalpha) is a member of neuronal cal...

journal_title：Neuroscience letters

authors： Masutani T,Taguchi K,Kumanogoh H,Nakamura S,Maekawa S

更新日期：2008-06-13 00:00:00

abstract：:In this study we examined the presence of dopamine D1 receptors in monkey amniotic epithelial cells (MAEC) using RT-PCR and radioligand binding experiments. We found that MAEC express D1 receptor mRNA that is having 99% homology with human dopamine D1 receptors. Saturation binding studies using [3H]SCH-23390 showed a ...

journal_title：Neuroscience letters

authors： Elwan MA,Ishii T,Ono F,Sakuragawa N

更新日期：1999-02-26 00:00:00

abstract：:Sciatic axotomy in 2-day-old rats (P2) causes lumbar motoneuron loss, which could be associated with nitric oxide (NO) production. NO may be produced by three isoforms of synthase (NOS): neuronal (nNOS), endothelial (eNOS) and inducible (iNOS). We investigated NOS expression and NO synthesis in the lumbar enlargement ...

journal_title：Neuroscience letters

authors： Rogério F,Teixeira SA,Júnior HJ,Maria CC,Vieira AS,de Rezende AC,Pereira GA,Muscará MN,Langone F

更新日期：2006-10-23 00:00:00

abstract：:Alterations in the structure and physiology of the prefrontal cortex (PFC) have been found in different psychiatric disorders and some of them involve inhibitory networks, especially in schizophrenia and major depression. Changes in the structure of these networks may be mediated by the polysialylated neural cell adhe...

journal_title：Neuroscience letters

authors： Gilabert-Juan J,Varea E,Guirado R,Blasco-Ibáñez JM,Crespo C,Nácher J

更新日期：2012-11-14 00:00:00

abstract：:To investigate diurnal variations in opiate receptor binding, the amount of specifically bound [3H]naloxone was measured at 4-h intervals across a 24-h period in the forebrains of rats that had been housed under a controlled light--dark cycle (lights on from 07.00 to 19.00 h) for 3 weeks. A significant rhythm with a p...

journal_title：Neuroscience letters

authors： Naber D,Wirz-Justice A,Kafka MS

更新日期：1981-01-01 00:00:00

abstract：:The distribution of premotor neurons projecting to motor nuclei of both the VIIth (VII) and XIIth (XII) nerves was examined in the pontomedullary reticular formation (RF) of the rat by using retrograde double labeling. After injection of two different tracers in the VII and the XII, most of the double labeled neurons ...

journal_title：Neuroscience letters

authors： Dauvergne C,Pinganaud G,Buisseret P,Buisseret-Delmas C,Zerari-Mailly F

更新日期：2001-09-28 00:00:00

abstract：:The acute effects of a high dose of d,l-propranolol on the levels of homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 4-hydroxy-3-methoxyphenylethylene glycol (HMPG) in rat brain regions were determined by mass fragmentography. A significant elevation of HVA was obtained in the olfactory tubercle but n...

journal_title：Neuroscience letters

authors： Wiesel FA

更新日期：1976-03-01 00:00:00

abstract：:A combination of immunocytochemistry with transmitter specific autoradiography at the electron microscopic level was used to identify vasoactive intestinal polypeptide (VIP)- or ACTH-containing neurons and serotoninergic nerve terminals in the suprachiasmatic (SCN) and arcuate nuclei (AN). We observed nerve terminals ...

journal_title：Neuroscience letters

authors： Kiss J,Léránth C,Halász B

更新日期：1984-02-10 00:00:00

abstract：:This is the first report of the presence of nitric oxide synthase (NOS) immunoreactivity and NADPH-diaphorase (NADPH-d) activity in a subpopulation of the intrinsic neurones that innervate the heart. A cytochemical technique to detect NADPH-d and antisera raised against purified rat cerebellar NOS were employed to exa...

journal_title：Neuroscience letters

authors： Hassall CJ,Saffrey MJ,Belai A,Hoyle CH,Moules EW,Moss J,Schmidt HH,Murad F,Förstermann U,Burnstock G

更新日期：1992-08-31 00:00:00

abstract：:Mood stabilizers are a category of medications used in the management of mood disorders. The mood stabilizing properties of lithium were first reported in 1949 by John Cade, and since then it has been considered the first line treatment for bipolar disorder. Despite presenting more differences than similarities, mood ...

journal_title：Neuroscience letters

authors： Pisanu C,Papadima EM,Del Zompo M,Squassina A

更新日期：2018-03-16 00:00:00

abstract：:Classical theories on absence epilepsy suggest that spike-wave discharge (SWDs) represent thalamo-cortical oscillations, where an abnormally excitable cortex interacts with thalamus and brain stem reticular formation. The limbic system is generally not included in any theory about the pathogenesis of absence seizures....

journal_title：Neuroscience letters

authors： Tolmacheva EA,van Luijtelaar G

更新日期：2007-04-06 00:00:00

abstract：:Recent imaging studies have reported the projection of semicircular canal signals onto wide regions of the cerebral cortex but little is known about otolith projections onto the cerebral cortex. We used functional magnetic resonance imaging (fMRI) to investigate the activation of the cortex by loud clicks that selecti...

journal_title：Neuroscience letters

authors： Miyamoto T,Fukushima K,Takada T,de Waele C,Vidal PP

更新日期：2007-08-09 00:00:00