Abstract:
:A 12h sleep deprivation enhances the expression of 5-hydroxytryptamine (5-HT) 1A receptors in rat hippocampus that recedes with 48h sleep recovery. The depressant effect of applied 5-HT on the field excitatory postsynaptic potentials recorded in the CA1 area, is also enhanced in hippocampi of SD rats. Following a 24 or 48h sleep recovery, the increase in the 5-HT effect subsided. These results have implications for therapeutics treating clinical depression.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Azizi H,Hwang J,Suen V,Kang NZ,Somvanshi R,Tadavarty R,Kumar U,Sastry BRdoi
10.1016/j.neulet.2017.06.053subject
Has Abstractpub_date
2017-08-10 00:00:00pages
151-155eissn
0304-3940issn
1872-7972pii
S0304-3940(17)30545-1journal_volume
655pub_type
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