Sleep deprivation induces changes in 5-HT actions and 5-HT1A receptor expression in the rat hippocampus.

Abstract:

:A 12h sleep deprivation enhances the expression of 5-hydroxytryptamine (5-HT) 1A receptors in rat hippocampus that recedes with 48h sleep recovery. The depressant effect of applied 5-HT on the field excitatory postsynaptic potentials recorded in the CA1 area, is also enhanced in hippocampi of SD rats. Following a 24 or 48h sleep recovery, the increase in the 5-HT effect subsided. These results have implications for therapeutics treating clinical depression.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Azizi H,Hwang J,Suen V,Kang NZ,Somvanshi R,Tadavarty R,Kumar U,Sastry BR

doi

10.1016/j.neulet.2017.06.053

subject

Has Abstract

pub_date

2017-08-10 00:00:00

pages

151-155

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(17)30545-1

journal_volume

655

pub_type

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