Abstract:
:Methamphetamine (METH) has been a worldwide health threat for years. Recent studies have reported that circular RNA (circRNA) are highly abundant and dynamically expressed in brain. However, connections between circRNA and METH-induced neurotoxicity remains indefinite. In the present study, primary cortical neurons were treated with METH in vitro. We profiled circRNA via high-throughput RNA sequencing and identified 2458 circRNAs. Bioinformatics analysis was performed to predict potential functions of these circRNAs which revealed several relevant pathways including 'morphine addiction' that may contribute to the pathogenesis of neuronal damage by METH. Especially, a METH-addicted mouse model was established with conditional place preference paradigm for validation of screened circRNAs. At last, we established co-expression networks of circRNAs with miRNAs and mRNAs to exhibit potential association among them. In conclusion, we firstly unveiled a role of circRNAs in METH-induced neuronal damage and METH addiction.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Li J,Shi Q,Wang Q,Tan X,Pang K,Liu X,Zhu S,Xi K,Zhang J,Gao Q,Hu Y,Sun Jdoi
10.1016/j.neulet.2019.02.032subject
Has Abstractpub_date
2019-05-14 00:00:00pages
146-153eissn
0304-3940issn
1872-7972pii
S0304-3940(19)30124-7journal_volume
701pub_type
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