Electrical and pharmacological properties of the slow depolarization induced by Schaffer collateral stimulation in astrocytes of the rat hippocampal CA1 region.

abstract：:To identify the roles of gamma-aminobutyric acid (GABA) transporter in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of GABA transporters (GAT) expression was conducted. GAT-1 immunoreactivity was more strongly detected in the pre-seizure group of seizure ...

journal_title：Neuroscience letters

authors： Kang TC,Kim HS,Seo MO,Park SK,Kwon HY,Kang JH,Won MH

更新日期：2001-09-07 00:00:00

abstract：:Hypoxic preconditioning (HP) is a novel strategy to make stem cells resistant to the ischemic environment they encounter after transplantation into injured tissue; this strategy improves survival of both the transplanted cells and the host cells at the injury site. Using both in vitro and in vivo injury models, we con...

journal_title：Neuroscience letters

authors： Oh JS,Ha Y,An SS,Khan M,Pennant WA,Kim HJ,Yoon DH,Lee M,Kim KN

更新日期：2010-03-26 00:00:00

abstract：:Rat myotubes were cultured with embryonic mouse spinal cord explants. After 4 days of co-culture, (miniature) endplate potentials, (M)EPPs, could be detected in 20-40% of the nerve-contacted myotubes. Polyclonal antibodies against the neural cell adhesion molecule N-CAM and monoclonal antibodies to its L2/HNK-1 carboh...

journal_title：Neuroscience letters

authors： Mehrke G,Jockusch H,Schachner M

更新日期：1987-08-05 00:00:00

abstract：:In this report the effects of phencyclidine (PCP) on physiologic variables, local cerebral blood flow (LCBF), and on hippocampal cell damage were measured in a rat model of forebrain ischemia (2-vessel occlusion and hypotension). Ischemia was induced for 10 min. LCBF was determined after 2 min of recirculation, using ...

journal_title：Neuroscience letters

authors： Sauer D,Nuglisch J,Rossberg C,Mennel HD,Beck T,Bielenberg GW,Krieglstein J

更新日期：1988-09-12 00:00:00

abstract：:To evaluate the roles of complement in kainic acid (KA)-induced neuronal damages, the immunohistochemical localization of the complement protein C3 was examined in rat hippocampus after systemic KA injection. The immunoreactivity for C3 was found in glial cells in control rats, and such glial cells were increased in n...

journal_title：Neuroscience letters

authors： Morita H,Suzuki K,Mori N,Yasuhara O

更新日期：2006-11-27 00:00:00

abstract：:Because there are sex differences in feeding-related behavior and orexin neurons are involved in feeding, we looked for a possible sex difference in the response of orexin neurons in the lateral hypothalamic area to fasting, using the phosphorylated cyclic AMP response element-binding protein (pCREB) as a marker of ne...

journal_title：Neuroscience letters

authors： Funabashi T,Hagiwara H,Mogi K,Mitsushima D,Shinohara K,Kimura F

更新日期：2009-09-29 00:00:00

abstract：:The neuropathological hallmarks of Alzheimer's disease (AD) include the presence of extracellular amyloid-beta peptide (Abeta) in the form of amyloid plaques in the brain parenchyma and neuronal loss. The mechanism associated with neuronal death by amyloid plaques is unclear but oxidative stress and glial activation h...

journal_title：Neuroscience letters

authors： Lee HJ,Lee JK,Lee H,Shin JW,Carter JE,Sakamoto T,Jin HK,Bae JS

更新日期：2010-08-30 00:00:00

abstract：:Depression is among the leading causes of disability and disease burden. Recent studies point to an involvement of altered serotonin1A receptor (5-HT1AR) -mediated adult neurogenesis in depression. However, the exact underlying mechanisms remain unclear, mainly due to the complexity of the serotonergic system with its...

journal_title：Neuroscience letters

authors： Noto B,Klempin F,Alenina N,Bader M,Fink H,Sander SE

更新日期：2016-10-28 00:00:00

abstract：:A predominant form of the GABAA/benzodiazepine receptor-Cl- channel complex is believed to consist of three different 48-55 kDa subunits (alpha, beta, gamma) with unknown stoichiometry. Plasmids containing the rat GABAA receptor cDNAs coding for alpha 1, beta 2, and gamma 2 were co-transfected, along with a plasmid en...

journal_title：Neuroscience letters

authors： Hamilton BJ,Lennon DJ,Im HK,Im WB,Seeburg PH,Carter DB

更新日期：1993-04-30 00:00:00

abstract：:Intolerance of uncertainty (IU), or the increased affective response to situations with uncertain outcomes, is an important component process of anxiety disorders. Increased IU is observed in panic disorder (PD), obsessive compulsive disorder (OCD) and generalized anxiety disorder (GAD), and is thought to relate to dy...

journal_title：Neuroscience letters

authors： Simmons A,Matthews SC,Paulus MP,Stein MB

更新日期：2008-01-10 00:00:00

abstract：:We recently showed that the RNA regulator, HuR, is translocated to the cytoplasm in astrocytes in the acute phase of spinal cord injury (SCI), consistent with its activation. HuR positively modulates expression of many pro-inflammatory factors, including IL-1β, TNF-α, and MMP-12, which are present at high levels in th...

journal_title：Neuroscience letters

authors： Kwan T,Floyd CL,Patel J,Mohaimany-Aponte A,King PH

更新日期：2017-06-09 00:00:00

abstract：:The association between (GT)n dinucleotide repeats in monoamine oxidase gene loci, monoamine oxidase A (MAOA) and B (MAOB), and Parkinson's disease (PD), Alzheimer's disease (AD), and Lewy body variant (LBV) of AD were determined. MAOA-GT polymorphisms were significantly associated with pure AD and LBV. MAOA-GT allele...

journal_title：Neuroscience letters

authors： Takehashi M,Tanaka S,Masliah E,Ueda K

更新日期：2002-07-19 00:00:00

abstract：:It is well known that genetic variants play a critical role in the pathogenesis of Alzheimer's disease (AD). In 2009, a genome-wide association study (GWAS) demonstrated that a single nucleotide polymorphism (SNP), rs6656401, in complement receptor 1 (CR1) is significantly associated with late-onset Alzheimer's diseas...

journal_title：Neuroscience letters

authors： Jin C,Li W,Yuan J,Xu W,Cheng Z

更新日期：2012-10-03 00:00:00

abstract：:A random sample of 60 late-onset Alzheimer's disease (AD) cases from a population-based study were apolipoprotein E (apoE) genotyped and clinically examined with a 3-year interval. The epsilon 4 allele carriers had a significantly lower age of disease onset compared to non-epsilon 4 carriers. However, no significant d...

journal_title：Neuroscience letters

authors： Basun H,Grut M,Winblad B,Lannfelt L

更新日期：1995-01-02 00:00:00

abstract：:Controversy exists regarding the site where anesthetics act in the brain to produce sedation and unconsciousness. Actions in the cerebral cortex and thalamus are likely, although the relative importance of each site is unclear. We used in computo modeling to investigate the sensitivity of cortical and thalamic neurons...

journal_title：Neuroscience letters

authors： Judge O,Hill S,Antognini JF

更新日期：2009-10-23 00:00:00

abstract：:Pharmacologic blockade of excitatory amino acid receptors, especially the N-methyl-D-aspartate-preferring subclass of glutamate receptors, has been shown to reduce neuronal damage in models of global cerebral ischemia followed by reperfusion. The pharmacologic blockade at the NMDA receptor attenuates infarct size foll...

journal_title：Neuroscience letters

authors： Roman R,Bartkowski H,Simon R

更新日期：1989-09-25 00:00:00

abstract：:The present study tests the hypothesis that nitration is a potential mechanism of N-methyl-D-aspartate (NMDA) receptor modification, by assessing the effect of peroxynitrite in vitro on the glutamate and ion-channel sites of the NMDA receptor in the fetal guinea pig. Nitration of NMDA receptor subunits was confirmed b...

journal_title：Neuroscience letters

authors： Zanelli SA,Ashraf QM,Delivoria-Papadopoulos M,Mishra OP

更新日期：2000-12-15 00:00:00

abstract：:Glufosinate ammonium, a broad-spectrum herbicide, causes convulsion in rodents and humans. Because of the structural similarities between glufosinate and glutamate, the convulsion induced by glufosinate ammonium may be ascribed to glutamate receptor activation. Three N-methyl-D-asparate (NMDA) receptor antagonists, di...

journal_title：Neuroscience letters

authors： Matsumura N,Takeuchi C,Hishikawa K,Fujii T,Nakaki T

更新日期：2001-05-18 00:00:00

abstract：:[125I]Iodomelatonin ([125I]MEL) binding in chicken spinal cords was characterized. The specific binding of [125I]MEL to the membrane preparation of spinal cord was rapid, stable, saturable, reversible, specific and of high affinity. Scatchard analysis of the specific binding data indicated an equilibrium dissociation ...

journal_title：Neuroscience letters

authors： Wan Q,Pang SF

更新日期：1993-11-26 00:00:00

abstract：:Both backward masking and transcranial magnetic stimulation (TMS) are capable of hindering perception of a visual target. To study the relationship between these two methods we applied TMS over the occipital pole in combination with the visual backward masking technique shine-through. The recently discovered weak shin...

journal_title：Neuroscience letters

authors： Kammer T,Scharnowski F,Herzog MH

更新日期：2003-06-12 00:00:00

abstract：:To assess the significance of the association between apolipoprotein E (APOE) epsilon 4 allele and amyloid beta-peptide (A-beta) deposits in the brain, we performed APOE-genotyping and measured the density of A-beta deposits, neuritic plaques and neurofibrillary tangles in 27 cases from the Charles Foix clinico-pathol...

journal_title：Neuroscience letters

authors： Berr C,Hauw JJ,Delaère P,Duyckaerts C,Amouyel P

更新日期：1994-09-12 00:00:00

abstract：:Constant bright light (LL) suppresses 24-h melatonin and many other behavioral and physiological rhythms in pigeons. LL also strongly suppresses sleep. Daily melatonin infusions in LL restore sleep to normal nocturnal levels of a light-dark cycle and continuous infusions sustain it for at least 10 days. Restoration of...

journal_title：Neuroscience letters

authors： Phillips NH,Berger RJ

更新日期：1992-10-12 00:00:00

abstract：:Following peripheral nerve section, the cell body and proximal axon undergo various physiological and morphological changes which may be associated with regrowth. We found that axotomy reduced the amplitude and duration of the afterhyperpolarization (AHP) of the action potential (AP) of bullfrog sympathetic neurones. ...

journal_title：Neuroscience letters

authors： Kelly ME,Gordon T,Shapiro J,Smith PA

更新日期：1986-06-18 00:00:00

abstract：:We studied event-related desynchronization (ERD) of the 8-13 Hz rhythm (mu rhythm) of the primary somatosensory cortex (SI) caused by contra- and ipsilateral median-nerve stimulation. We used whole-head magnetoencephalography (MEG) and wavelet analysis together with our newly developed color-coded single-trial ERD dis...

journal_title：Neuroscience letters

authors： Nikouline VV,Linkenkaer-Hansen K,Wikström H,Kesäniemi M,Antonova EV,Ilmoniemi RJ,Huttunen J

更新日期：2000-11-24 00:00:00

abstract：:Effect of 1-methyl-4-phenylpyridinium ion (MPP+) on adenosine triphosphate (ATP) synthesis was studied using isolated mitochondrial preparations from mouse brains. Oxidation of glutamate + malate in the mitochondria estimated by polarography was significantly inhibited by MPP+, and synthesis of ATP was inhibited to ap...

journal_title：Neuroscience letters

authors： Mizuno Y,Suzuki K,Sone N,Saitoh T

更新日期：1987-10-16 00:00:00

abstract：:New psychoactive substances (NPSs), i.e., newly designed substances with chemical residues that are slightly different from those of known psychoactive substances, have been emerging since the late 2000s, and social problems related to the use of these substances are increasing globally. Two such NPSs are 4-chloro-2,5...

journal_title：Neuroscience letters

authors： Cha HJ,Jeon SY,Jang HJ,Shin J,Kim YH,Suh SK

更新日期：2018-05-29 00:00:00

abstract：:Double immunostaining for oxytocin (OT) and Fos was used to study the oxytocinergic system of the rat hypothalamic paraventricular nucleus (PVN) following intraperitoneal insulin injections. The expression of c-fos in the PVN appeared about 3 h after insulin treatment and was very high after 5 h while no labelling was...

journal_title：Neuroscience letters

authors： Griffond B,Deray A,Bahjaoui-Bouhaddi M,Colard C,Bugnon C,Fellmann D

更新日期：1994-08-29 00:00:00

abstract：:Lucifer Yellow (LY) selectively labels embryonic chick amacrine cells from days 11 until 14 in vivo. Its usefulness as an in vitro marker was investigated. In vivo labeling and subsequent culturing was not possible due to dye leakage. Neurons, however, could be labeled at various times in vitro. The number of neurons ...

journal_title：Neuroscience letters

authors： Zeevalk GD,Hyndman AG

更新日期：1986-03-14 00:00:00

abstract：:This study examined the effects of exposure to low concentrations (0.1-100 nM) of bisphenol A (BPA) or nonylphenol (NP) on neuronal differentiation in pheochromocytoma PC12 cells. Pre-exposure to BPA for a week or a month, but not for a day, decreased neuronal differentiation in PC12 cells. Likewise, one week's pre-ex...

journal_title：Neuroscience letters

authors： Nishimura Y,Nagao T,Fukushima N

更新日期：2014-06-06 00:00:00

abstract：:There is evidence indicating that the brain's dopaminergic system is involved in age-associated memory impairment. However, specific roles in this process for the different dopamine receptor subtypes have not been elucidated. The cAMP-response element binding protein (CREB) is one of the cellular molecules that have b...

journal_title：Neuroscience letters

authors： Xing B,Meng X,Wei S,Li S

更新日期：2010-09-13 00:00:00